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Home / Equine Research Bank / Equine Vet J / State of the art: stem cells in equine regenerative medicine...
Equine veterinary journal2014; 47(2); 145-154; doi: 10.1111/evj.12311

State of the art: stem cells in equine regenerative medicine.

Abstract: According to Greek mythology, Prometheus' liver grew back nightly after it was removed each day by an eagle as punishment for giving mankind fire. Hence, contrary to popular belief, the concept of tissue and organ regeneration is not new. In the early 20th century, cell culture and ex vivo organ preservation studies by Alexis Carrel, some with famed aviator Charles Lindbergh, established a foundation for much of modern regenerative medicine. While early beliefs and discoveries foreshadowed significant accomplishments in regenerative medicine, advances in knowledge within numerous scientific disciplines, as well as nano- and micromolecular level imaging and detection technologies, have contributed to explosive advances over the last 20 years. Virtually limitless preparations, combinations and applications of the 3 major components of regenerative medicine, namely cells, biomaterials and bioactive molecules, have created a new paradigm of future therapeutic options for most species. It is increasingly clear, however, that despite significant parallels among and within species, there is no 'one-size-fits-all' regenerative therapy. Likewise, a panacea has yet to be discovered that completely reverses the consequences of time, trauma and disease. Nonetheless, there is no question that the promise and potential of regenerative medicine have forever altered medical practices. The horse is a relative newcomer to regenerative medicine applications, yet there is already a large body of work to incorporate novel regenerative therapies into standard care. This review focuses on the current state and potential future of stem cells in equine regenerative medicine.
© 2014 EVJ Ltd.
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Publication Date: 2014-09-10 PubMed ID: 24957845DOI: 10.1111/evj.12311Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't
  • Review

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article discusses the history, current applications, and future potential of stem cells in regenerative medicine for horses. The core concept of the paper revolves around the advancements in this field over the last two decades and how it has revolutionized therapeutic options across species.

Historical Background

  • The research paper opens with a nod to Greek mythology to emphasize that the concept of tissue and organ regeneration has been around for a long time.
  • It references early 20th-century studies by Alexis Carrel and Charles Lindbergh on cell culture and organ preservation, which laid the foundation for modern regenerative medicine.

Advancements in Regenerative Medicine

  • In recent decades, regenerative medicine has experienced explosive growth due to advancements in various scientific disciplines and technologies.
  • This includes developments in nano- and micromolecular imaging and detection technologies, which have made it possible to prepare, combine and apply the three major components of regenerative therapy – cells, biomaterials, and bioactive molecules, in almost infinite ways.
  • This has opened up new possibilities for therapeutic options for various species, indicating an enormous shift in medical practice.

Challenges and Limitations

  • Despite these advancements, the paper highlights that there’s no “one-size-fits-all” therapy in regenerative medicine. Responses can vary even within the same species, indicating the need for personalized or customized treatments.
  • The ideal solution that fully reverses the impact of time, trauma, and disease remains elusive. Though regenerative medicine has potential, it is not a panacea.

Application in Equine Medicine

  • The horse is a relatively new entry in the application of regenerative medicine, but there is already substantial work being done in incorporating novel regenerative therapies into standard equine care.
  • The focus of this review is on the current status and future potential of stem cells in equine regenerative medicine, suggesting that the promising results of stem cell therapy observed in other species are being extended to equine applications.

Cite This Article

APA
Lopez MJ, Jarazo J. (2014). State of the art: stem cells in equine regenerative medicine. Equine Vet J, 47(2), 145-154. https://doi.org/10.1111/evj.12311

Publication

Equine veterinary journal
ISSN: 2042-3306
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 47
Issue: 2
Pages: 145-154

Researcher Affiliations

Lopez, M J
  • Laboratory for Equine and Comparative Orthopedic Research, Equine Health Studies Program, Department of Veterinary Clinical Sciences, Louisiana State University, Baton Rouge, USA.
Jarazo, J

    MeSH Terms

    • Animals
    • Horse Diseases / therapy
    • Horses / injuries
    • Regenerative Medicine
    • Stem Cell Transplantation / veterinary
    • Stem Cells / physiology
    • Tissue Engineering / veterinary

    Citations

    This article has been cited 13 times.
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