Status of natural infection with Japanese encephalitis virus in Japan: prevalence of antibodies to the nonstructural 1 protein among humans and horses.
Abstract: The literature on natural infections with Japanese encephalitis virus in Japan and subclinical:clinical infection rates was summarized. To detect natural infections, conventional serologic methods were used in the past, while nonstructural 1 protein-based methods have been used recently. Annual infection rates in humans and horses indicated the status of natural virus activity in Japan.
Publication Date: 2009-09-30 PubMed ID: 19799840DOI: 10.1016/j.vaccine.2009.09.052Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research paper examines the prevalence of Japanese encephalitis virus in Japan by studying the prevalence of antibodies to the virus’s nonstructural 1 protein in humans and horses. Traditional serologic methods and newly introduced nonstructural 1 protein-based methods were used to identify infections and natural virus activity in Japan.
Understanding Japanese Encephalitis Virus
- The Japanese encephalitis virus is a common cause of viral brain inflammation, particularly in Asia.
- It predominantly affects humans and horses, with mosquitoes serving as vectors for transmission.
- Identifying the prevalence of Japanese encephalitis is crucial to limiting its spread and treating those who are infected.
The Role of Antibodies to the Nonstructural 1 Protein
- The nonstructural 1 protein is a component of the Japanese encephalitis virus.
- Active infections produce antibodies that recognize and fight this protein, making it a useful marker for identifying infections.
- By identifying the presence and prevalence of these antibodies in populations of humans and horses, researchers can gauge the extent of Japanese encephalitis virus infection.
Serologic Methods and Nonstructural 1 Protein-Based Methods
- Conventional serologic methods, involving the study of serum and bodily fluids, were previously used to detect natural infections.
- More recently, nonstructural 1 protein-based methods have been developed. These are more precise and sensitive, and can detect the presence of the nonstructural 1 protein, indicating an active infection.
- The use of these methods provides more accurate data regarding the prevalence and spread of the Japanese encephalitis virus.
Annual Infection Rates in Humans and Horses
- Studying annual infection rates in humans and horses can inform researchers about the status of natural virus activity in Japan.
- These rates can indicate how common the Japanese encephalitis virus is, and how effective efforts to control its spread have been.
- This data is crucial for improving public health strategies and working towards the elimination of the virus.
Cite This Article
APA
Konishi E.
(2009).
Status of natural infection with Japanese encephalitis virus in Japan: prevalence of antibodies to the nonstructural 1 protein among humans and horses.
Vaccine, 27(50), 7129-7130.
https://doi.org/10.1016/j.vaccine.2009.09.052 Publication
Researcher Affiliations
- Department of International Health, Kobe University Graduate School of Health Sciences, 7-10-2 Tomogaoka Suma-ku, Kobe 654-0142, Japan. ekon@kobe-u.ac.jp
MeSH Terms
- Animals
- Antibodies, Viral / blood
- Encephalitis Virus, Japanese / immunology
- Encephalitis, Japanese / epidemiology
- Encephalitis, Japanese / immunology
- Encephalitis, Japanese / veterinary
- Horse Diseases / epidemiology
- Horse Diseases / immunology
- Horses / immunology
- Humans
- Japan / epidemiology
- Prevalence
- Seroepidemiologic Studies
- Viral Nonstructural Proteins / immunology
Citations
This article has been cited 4 times.- Galula JU, Salem GM, Destura RV, Remenyi R, Chao DY. Comparable Accuracies of Nonstructural Protein 1- and Envelope Protein-Based Enzyme-Linked Immunosorbent Assays in Detecting Anti-Dengue Immunoglobulin G Antibodies. Diagnostics (Basel) 2021 Apr 21;11(5).
- Jeewandara C, Gomes L, Paranavitane SA, Tantirimudalige M, Panapitiya SS, Jayewardene A, Fernando S, Fernando RH, Prathapan S, Ogg GS, Malavige GN. Change in Dengue and Japanese Encephalitis Seroprevalence Rates in Sri Lanka. PLoS One 2015;10(12):e0144799.
- Wang H, Liang G. Epidemiology of Japanese encephalitis: past, present, and future prospects. Ther Clin Risk Manag 2015;11:435-48.
- Fox A, Whitehead S, Anders KL, Hoa LNM, Mai LQ, Thai PQ, Yen NT, Duong TN, Thoang DD, Farrar J, Wertheim H, Simmons C, Hien NT, Horby P. Investigation of dengue and Japanese encephalitis virus transmission in Hanam, Viet Nam. Am J Trop Med Hyg 2014 May;90(5):892-896.
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