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Studies on the frequency and associations of equine leucocyte antigens in sarcoid and summer dermatitis.
Abstract: The equine leucocyte antigen (ELA) types and the clinical diagnosis for equine sarcoid and summer dermatitis were evaluated in 2026 horses representing five breeds. Data were analysed in unrelated animals and in family material. In the case of equine sarcoid, a strong association was observed between the ELA class II DW13 antigen and its effect on Swiss (cP < 0.001), French (cP < 0.0001) and Irish (cP < 0.01) Warmblood horses. The class I antigen A3 occurred more frequently in sarcoid-affected French horses (cP < 0.001). These results confirm our earlier findings (Gerber et al. 1988). Among Freiberger horses, which lack the ELA DW13 and A3 specificities, a breed-specific class I antigen, ABe108, displayed an increased frequency (cP < 0.05) in the affected group. Among Arabian horses, a tendency for increased frequency of the A1 antigen was observed in the affected animals, but the number of affected horses is too small for statistical significance. The Mendelian segregation in diseased half-siblings by ELA DW13 heterozygous stallions showed a strong association (P < 0.0001) between the inherited DW13 antigen and susceptibility to the sarcoid effect. In the case of summer dermatitis, previously published data (Marti et al. 1992) have been extended. The ELA types in four multiple-case families, founded by the same stallion, were analysed for an association with the effect of sarcoid. Eight out of nine ELA-typed affected offspring inherited the paternal haplotype A15, DW23 in contrast to nonaffected offspring where three out of 12 displayed these antigens (P < 0.005).(ABSTRACT TRUNCATED AT 250 WORDS)
Publication Date: 1994-06-01 PubMed ID: 7943987DOI: 10.1111/j.1365-2052.1994.tb00406.xGoogle Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Comparative Study
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research article explores the connection between equine leucocyte antigens (ELAs) and the occurrence of equine sarcoid and summer dermatitis in horses. It has been found that certain antigens are more prevalent in horses that are afflicted by these conditions.
Study Overview
This research evaluated the ELA types along with the clinical diagnosis for equine sarcoid and summer dermatitis among 2026 horses from five different breeds. Their primary concern was to detect any potential link between certain antigens and the frequency of these diseases.
Association of ELA with Equine Sarcoid
- The research found a strong correlation between the ELA class II DW13 antigen and equine sarcoid, particularly amongst Swiss, French, and Irish Warmblood horses.
- Another antigen, the class I A3 antigen, was found to be more commonly present in French horses that had sarcoid.
- These findings paralleled earlier research conducted by Gerber et al. in 1988.
Breed-Specific Findings
- In Freiberger horses, which did not have the ELA DW13 and A3 specificities, an antigen specific to the breed (ABe108) was found to occur more frequently in horses affected by sarcoid.
- A slightly increased occurrence of the A1 antigen was noted amongst Arabian horses with the disease, but the sample size was too small to draw statistically significant conclusions.
- Mendelian segregation patterns in sick half-siblings by ELA DW13 heterozygous stallions showed a clear link between the inherited DW13 antigen and predisposition to sarcoid.
Associations with Summer Dermatitis
- The research extends previously published data relating to summer dermatitis.
- In the case of four multiple-case families that were descended from the same stallion and displayed summer dermatitis, eight out of nine ELA-typed affected offspring inherited the paternal haplotype A15, DW23. In contrast, these antigens showed up in only three out of 12 non-affected offspring.
Hence, the research establishes a correlation between the prevalence of certain ELA antigens and the occurence of equine sarcoid and summer dermatitis, paving the way for more targeted diagnoses and potential treatments.
Cite This Article
APA
Lazary S, Marti E, Szalai G, Gaillard C, Gerber H.
(1994).
Studies on the frequency and associations of equine leucocyte antigens in sarcoid and summer dermatitis.
Anim Genet, 25 Suppl 1, 75-80.
https://doi.org/10.1111/j.1365-2052.1994.tb00406.x Publication
Researcher Affiliations
- Division of Immunogenetics, University of Berne, Switzerland.
MeSH Terms
- Alleles
- Animals
- Bovine papillomavirus 1
- Dermatitis / genetics
- Dermatitis / immunology
- Dermatitis / veterinary
- Female
- Gene Frequency
- Histocompatibility Antigens / genetics
- Horse Diseases / genetics
- Horse Diseases / immunology
- Horses
- Leukocytes / immunology
- Male
- Papillomavirus Infections / genetics
- Papillomavirus Infections / immunology
- Papillomavirus Infections / veterinary
- Pedigree
- Sarcoidosis / genetics
- Sarcoidosis / immunology
- Sarcoidosis / veterinary
- Species Specificity
- Tumor Virus Infections / genetics
- Tumor Virus Infections / immunology
- Tumor Virus Infections / veterinary
Citations
This article has been cited 8 times.- Unger L, Jagannathan V, Pacholewska A, Leeb T, Gerber V. Differences in miRNA differential expression in whole blood between horses with sarcoid regression and progression. J Vet Intern Med 2019 Jan;33(1):241-250.
- Sadeghi R, Moradi-Shahrbabak M, Miraei Ashtiani SR, Miller DC, Antczak DF. MHC haplotype diversity in Persian Arabian horses determined using polymorphic microsatellites. Immunogenetics 2018 May;70(5):305-315.
- Miller D, Tallmadge RL, Binns M, Zhu B, Mohamoud YA, Ahmed A, Brooks SA, Antczak DF. Polymorphism at expressed DQ and DR loci in five common equine MHC haplotypes. Immunogenetics 2017 Mar;69(3):145-156.
- Wilson AD, Hicks C. Both tumour cells and infiltrating T-cells in equine sarcoids express FOXP3 associated with an immune-supressed cytokine microenvironment. Vet Res 2016 May 9;47(1):55.
- Klumplerova M, Vychodilova L, Bobrova O, Cvanova M, Futas J, Janova E, Vyskocil M, Vrtkova I, Putnova L, Dusek L, Marti E, Horin P. Major histocompatibility complex and other allergy-related candidate genes associated with insect bite hypersensitivity in Icelandic horses. Mol Biol Rep 2013 Apr;40(4):3333-40.
- Andersson LS, Swinburne JE, Meadows JR, Broström H, Eriksson S, Fikse WF, Frey R, Sundquist M, Tseng CT, Mikko S, Lindgren G. The same ELA class II risk factors confer equine insect bite hypersensitivity in two distinct populations. Immunogenetics 2012 Mar;64(3):201-8.
- Vychodilova L, Plasil M, Futas J, Kopecka A, Molinkova D, Wijacki T, Jahn P, Knoll A, Horin P. Genetic susceptibility to sarcoid in Arabian horses: associations with MHC class II and compound MHC class I/KLRA genotypes. Vet Res Commun 2025 May 1;49(3):184.
- Quatember H, Nell B, Richter B, Rigler D, Dolezal M, Sykora S, Wallner B. Studying the Impact of the DDB2 T338M Missense Mutation on the Development of Equine Squamous Cell Carcinoma and Sarcoid. Animals (Basel) 2025 Mar 22;15(7).
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