Study design synopsis: Designing and performing pharmacokinetic studies for systemically administered drugs in horses.
Abstract: The goal of this editorial is to discuss best practice design, execution and reporting of a pharmacokinetic (PK) study in horses. Our target readers are clinicians who plan to perform this type of research, in a field, clinic or research setting but we also hope that this article might help readers of such work to appraise the articles and understand the quality of the studies. Our emphasis will be on appropriate study design and analytical method, drug and drug formulation choice and route of administration, animal choice, sample collection, storage and shipping, and reporting, rather than the PK data analysis itself.
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Publication Date: 2020-08-05 PubMed ID: 32748990DOI: 10.1111/evj.13312Google Scholar: Lookup
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- Editorial
Summary
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The research article predominantly focuses on optimal practices in conducting and communicating pharmacokinetic (PK) studies on horses, concerning systemic drug administration. It delivers valuable insights for veterinarians, scholars, and other practitioners engaged in horse-related medical research.
Study Design and Analytical Method
- The research outlines the importance of a well-crafted study design in collecting reliable and relevant data in pharmacokinetic studies on horses.
- Moreover, the authors emphasize on using a suitable analytical method that aligns with the study’s objectives and nature of the drug tested.
Choice of Drug and Its Administration
- The manuscript underlines the necessity of thoughtful drug and drug formulation selection. The choice should consider factors such as the purpose and potential side effects of the medicine.
- The route of drug administration also plays a crucial role in generating viable data and subsequently impacts the study outcomes.
Participant Selection
- This research emphasizes on the appropriateness of animal selection. The authors caution practitioners to carefully choose horses that are suitable for pharmacokinetic studies, depending on the specifics of individual studies.
Sample Collection, Storage, and Shipping
- The paper outlines the importance of well-planned sample collection procedures, which must ensure that samples are preserved in a state suitable for animated analysis.
- It also indicates the necessity of correct sample shipping and storage practices that assure sample integrity until the time of analysis.
Report Writing
- Finally, the authors stress the importance of accurate and comprehensive reporting of the study process and results. This transparency enables others to evaluate the research’s quality, methods, and conclusions.
Notably, the researchers do not concentrate on the analysis of pharmacokinetic data itself, but instead, they steer their attention towards foundational elements that add up to the overall success of a pharmacokinetic study.
Cite This Article
APA
Bermingham E, Davis JL, Whittem T.
(2020).
Study design synopsis: Designing and performing pharmacokinetic studies for systemically administered drugs in horses.
Equine Vet J, 52(5), 643-650.
https://doi.org/10.1111/evj.13312 Publication
Researcher Affiliations
- Animal Clinical Investigation LLC, Chevy Chase, MD, USA.
- Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, USA.
- University of Melbourne, Melbourne Veterinary School, Werribee, VIC, Australia.
MeSH Terms
- Animals
- Horses
- Pharmaceutical Preparations
- Research Design
References
This article includes 22 references
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Citations
This article has been cited 2 times.- O O, Simon BT, Ebner LS, Lizarraga I, Sun X, Cox SK. The pharmacokinetics and pharmacodynamics of midazolam after intravenous administration to donkeys (Equus africanus asinus).. Can J Vet Res 2022 Apr;86(2):125-131.
- Martinez MN, Papich MG, Fahmy R. Impact of gastrointestinal differences in veterinary species on the oral drug solubility, in vivo dissolution, and formulation of veterinary therapeutics.. ADMET DMPK 2022;10(1):1-25.
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