Successful resection of a recurrent leiomyosarcoma of the pulmonary trunk.
Abstract: We successfully performed a total resection of the pulmonary artery trunk and replaced it with an equine pericardial xenograft roll in a patient with a recurrent leiomyosarcoma. We believe, based on anatomic and embryologic principles, total rather than partial resection of the pulmonary artery trunk should be the treatment of choice for primary leiomyosarcomas of the pulmonary artery.
Publication Date: 1993-04-01 PubMed ID: 8466316DOI: 10.1016/0003-4975(93)90139-9Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
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Summary
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The research article reports the successful removal of a recurrent leiomyosarcoma, a rare type of cancer, from the pulmonary artery trunk of a patient, using a piece of tissue from a horse’s heart sac. The researchers suggest that complete removal of the pulmonary artery trunk should be the preferred method of treatment for primary leiomyosarcomas of the pulmonary artery, based on understandings of anatomy and embryology.
About Leiomyosarcoma and the Pulmonary Artery Trunk
- Leiomyosarcoma is a rare type of cancer that develops from smooth muscle cells. These tumors can occur anywhere in the body where smooth muscles are present.
- When it occurs in the pulmonary artery trunk – the large blood vessel leading out of the heart and carrying oxygen-depleted blood to the lungs – it poses significant risks and treatment challenges.
Recurrent Leiomyosarcoma
- The particular case in this study involves a recurrent leiomyosarcoma, meaning the cancer came back after initial treatment.
- Recurrent leiomyosarcomas are especially challenging to treat because they tend to be resistant to therapy and are more aggressive than the initial occurrence.
The Procedure
- The researchers performed a total resection of the pulmonary artery trunk – that is, they completely removed it. This approach contrasts with partial resection, where only a part of the artery is removed.
- This resected artery was then replaced with an equine pericardial xenograft roll, which is tissue taken from the heart sac (pericardium) of a horse. This replacement is necessary to ensure that blood can continue to flow to the lungs post-surgery.
Implications for Future Treatments
- Based on the success of this surgical procedure, the researchers propose that total rather than partial resection of the pulmonary artery trunk should be the preferred treatment for primary leiomyosarcomas of the pulmonary artery.
- Their recommendation is grounded in their understanding of anatomy and embryology, although the specific principles they refer to are not detailed in the summary provided.
- More research and case studies are likely needed to validate this treatment approach and determine its broader applicability.
Cite This Article
APA
Okada K, Okada M, Yamamoto S, Mukai T, Tsukube T, Matsuda H, Okada M.
(1993).
Successful resection of a recurrent leiomyosarcoma of the pulmonary trunk.
Ann Thorac Surg, 55(4), 1009-1012.
https://doi.org/10.1016/0003-4975(93)90139-9 Publication
Researcher Affiliations
- Department of Surgery, Kobe University School of Medicine, Japan.
MeSH Terms
- Aged
- Bioprosthesis
- Blood Vessel Prosthesis
- Female
- Humans
- Leiomyosarcoma / surgery
- Neoplasm Recurrence, Local / surgery
- Pulmonary Artery / surgery
- Reoperation
- Transplantation, Heterologous
- Vascular Diseases / surgery
Citations
This article has been cited 4 times.- Bandyopadhyay D, Panchabhai TS, Bajaj NS, Patil PD, Bunte MC. Primary pulmonary artery sarcoma: a close associate of pulmonary embolism-20-year observational analysis. J Thorac Dis 2016 Sep;8(9):2592-2601.
- Lv Y, Wang F, Qian W, Sun G. Treatment of a recurrent pulmonary artery leiomyosarcoma with a combination of surgery, chemotherapy, and radiotherapy: A case report and literature review. Oncol Lett 2015 Apr;9(4):1545-1548.
- Johansson L, Carlén B. Sarcoma of the pulmonary artery: report of four cases with electron microscopic and immunohistochemical examinations, and review of the literature. Virchows Arch 1994;424(2):217-24.
- Zhang W, Li P, Yu J. Primary Pulmonary Artery Leiomyosarcoma with Pulmonary Metastasis Depicted on Enhanced Computer Tomography: A Case Description and an Analysis of the Literature. J Cardiovasc Dev Dis 2023 Dec 20;11(1).
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