Superovulation in mares.
Abstract: Embryo recovery from single ovulating mares is approximately 50 per cent per estrous cycle. Superovulation could be used to increase embryo recovery and provide extra embryos for embryo freezing. This review addresses some historical approaches to superovulation, as well as examines factors that affect the response of mares to equine FSH. eCG, GnRH and inhibin vaccines have been of limited success in stimulating multiple ovulation. Numerous studies have shown that injection of equine pituitary extract (EPE) will result in three to four ovulations per estrous cycle and two embryos. A purified, standardized EPE preparation (eFSH) also results in a similar response to EPE. Factors affecting the response to EPE and eFSH include day of initial treatment, size of largest follicle at initial treatment and frequency of injection. Embryos from single ovulating, untreated mares and eFSH-treated mares provide similar pregnancy rates upon nonsurgical transfer. Five to 7 days of eFSH treatment also has been shown to hasten the first ovulation of the breeding season. Potential problems after eFSH injections include anovulatory or luteinized follicles and overstimulation. Studies are needed to further evaluate the criteria for initiation of treatment and to determine how to increase ovulation rate without decreasing embryo recovery per ovulation.
(c)2006 Elsevier B.V. All rights reserved.
Publication Date: 2006-06-12 PubMed ID: 16769185DOI: 10.1016/j.anireprosci.2006.04.054Google Scholar: Lookup
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- Journal Article
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Summary
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The research article discusses the use of a commercially available product, eFSH (equine follicle-stimulating hormone), for superovulation in mares. The primary focus is on how eFSH can increase the number of follicles for oocyte collection, provide extra embryos for freezing, enhance fertility in less fertile mares, and expedite the first ovulation of the year.
Background and Introduction
- The research begins with a brief historical account of superovulation and the use of hormones in mares. It introduces the concept of superovulation, which involves causing a mare to develop and release multiple eggs during a single ovulation cycle.
- They mention a commercial product that has become recently available, known as eFSH, which can be used for superovulation in mares. The application of this product is explored in detail throughout the article.
The Use and Benefits of eFSH
- One aspect the research paper delves into is the benefits of using eFSH to stimulate multiple follicular developments. This results in an increased number of follicles available for oocyte or egg cell collection. Such a process can help bolster the efficacy of artificial insemination and Embryo Transfer (ET) procedures.
- A secondary benefit noted is the availability of additional embryos for freezing. This allows for the preservation of a mare’s genetic material and the possibility of subsequent implantations.
Enhancement of Fertility and Early Ovulation
- The usage of eFSH as a means to enhance fertility in subfertile mares is also discussed. Subfertile mares are those with lower natural fertility rates, and the application of eFSH could aid in improving their fertility.
- The paper also highlights how the use of eFSH can help in advancing the first ovulation of the year, effectively speeding up the breeding timeline.
Conclusion
- Overall, the research article centralizes on the effectiveness of eFSH for inducing superovulation in mares and its multitude of benefits. It presents the commercial product eFSH as a readily available solution for practitioners seeking to enhance ovulation rates and improve fertility outcomes in mares.
Cite This Article
APA
Squires EL, McCue PM.
(2006).
Superovulation in mares.
Anim Reprod Sci, 99(1-2), 1-8.
https://doi.org/10.1016/j.anireprosci.2006.04.054 Publication
Researcher Affiliations
- Animal Reproduction and Biotechnology Laboratory, ARBL Building, Foothills Campus, Colorado State University, Fort Collins, CO 80523-1683, USA. smcdoug@ahc.co.nz
MeSH Terms
- Animal Husbandry / methods
- Animals
- Embryo, Mammalian / physiology
- Female
- Follicle Stimulating Hormone / physiology
- Horses / physiology
- Ovulation Induction / methods
- Ovulation Induction / veterinary
- Pituitary Gland / chemistry
- Superovulation / physiology
References
This article includes 26 references
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