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Home / Equine Research Bank / Equine Vet J / Surgical treatment of 45 horses affected by squamous cell ca...
Equine veterinary journal2000; 32(5); 406-410; doi: 10.2746/042516400777591093

Surgical treatment of 45 horses affected by squamous cell carcinoma of the penis and prepuce.

Abstract: The medical records of 45 horses treated for suspected squamous cell carcinoma of the penis and/or prepuce were reviewed. The age of 40 horses was known, and these had a mean age of 17.4 years. The duration of neoplasia was known for only 3 of the 45 horses. The results of histological evaluation of lesions, available for 35 horses, confirmed that the diseased tissue was squamous cell carcinoma. The location of gross neoplastic lesions was recorded for 43 horses; the glans penis was involved in 24 horses, the body of the penis or the inner lamina of the preputial fold in 27 horses, and the external fold of the prepuce in 10 horses. Surgical treatments of these horses included phallectomy (penile amputation) in 35 horses, segmental posthectomy in 4 horses, phallectomy plus segmental posthectomy in 2 horses, and en bloc resection of the penis, prepuce and superficial inguinal lymph nodes with penile retroversion in 4 cases. Short-term complications in the immediate postoperative period included preputial oedema and haemorrhage at the end of urination. One horse developed acute urinary retention because of severe urethral oedema. Long-term (>1 year) follow-up information was obtained for 31 horses. Neoplasia of the penis and/or prepuce recurred in 6 of these 31 horses (19%), and in 5 of these the recurrence necessitated euthanasia of the horse.
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Publication Date: 2000-10-19 PubMed ID: 11037262DOI: 10.2746/042516400777591093Google Scholar: Lookup
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Summary

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This study reviews the cases of 45 horses that underwent surgical treatment for squamous cell carcinoma of the penis and/or prepuce. The report details the outcomes of different surgical procedures and the recurrence rates of the cancer.

Background of the Cases Reviewed

  • The article reviews 45 medical cases of horses that underwent surgery for suspected squamous cell carcinoma. Squamous cell carcinoma is a type of skin cancer that affects the penis and/or prepuce (a fold of skin at the end of the penis) in equines.
  • The mean age of the 40 horses was 17.4 years. Information about the duration of the newly formed cancer was known for only 3 of the 45 horses.
  • The lesions were histologically (microscopically) evaluated and proved to be squamous cell carcinoma in 35 horses.

Details of the Cancerous Lesions

  • The location of the gross (visible) neoplastic (cancerous) lesions was documented for 43 of the horses. They were found on the glans of the penis for 24 horses, on the body of the penis or the inner lamina of the preputial fold of 27 horses, and on the external fold of the prepuce of 10 horses. This suggests that this type of cancer can affect different parts of the horse’s genitalia.

Surgical Procedures Used

  • The horses underwent different types of surgeries including phallectomy (penile amputation) for 35 horses, segmental posthectomy (partial resection of the prepuce) for 4 horses, combined phallectomy and segmental posthectomy for 2 horses, and a comprehensive resection of the penis, prepuce, and superficial inguinal lymph nodes with penile retroversion for 4 horses.

Postoperative Complications and Follow-up Information

  • The paper notes common short-term complications such as swelling (edema) of the prepuce and blood loss at the end of urination. One case led to acute urinary retention due to significant urethral swelling.
  • Long-term follow-up information, available for 31 horses, revealed squamous cell carcinoma recurrence in 6 of them (19%). This led to euthanasia in 5 of the affected horses, suggesting a significant impact on their quality of life.

The findings of this study could help provide insight for veterinary practitioners on postoperative complications, the success rate, and recurrence of squamous cell carcinoma following different surgical procedures involved in this particular cancer’s treatment.

Cite This Article

APA
Mair TS, Walmsley JP, Phillips TJ. (2000). Surgical treatment of 45 horses affected by squamous cell carcinoma of the penis and prepuce. Equine Vet J, 32(5), 406-410. https://doi.org/10.2746/042516400777591093

Publication

Equine veterinary journal
ISSN: 0425-1644
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 32
Issue: 5
Pages: 406-410

Researcher Affiliations

Mair, T S
  • The Bell Equine Veterinary Clinic, Maidstone, Kent, UK.
Walmsley, J P
    Phillips, T J

      MeSH Terms

      • Animals
      • Carcinoma, Squamous Cell / surgery
      • Carcinoma, Squamous Cell / veterinary
      • Euthanasia / veterinary
      • Horse Diseases / surgery
      • Horses
      • Male
      • Neoplasm Recurrence, Local / veterinary
      • Penile Neoplasms / surgery
      • Penile Neoplasms / veterinary
      • Penis / surgery
      • Retrospective Studies

      Citations

      This article has been cited 8 times.
      1. Hainisch EK, Jindra C, Kirnbauer R, Brandt S. Papillomavirus-like Particles in Equine Medicine.. Viruses 2023 Jan 25;15(2).
        doi: 10.3390/v15020345pubmed: 36851559google scholar: lookup
      2. Miglinci L, Reicher P, Nell B, Koch M, Jindra C, Brandt S. Detection of Equine Papillomaviruses and Gamma-Herpesviruses in Equine Squamous Cell Carcinoma.. Pathogens 2023 Jan 23;12(2).
        doi: 10.3390/pathogens12020179pubmed: 36839451google scholar: lookup
      3. Armando F, Mecocci S, Orlandi V, Porcellato I, Cappelli K, Mechelli L, Brachelente C, Pepe M, Gialletti R, Ghelardi A, Passeri B, Razzuoli E. Investigation of the Epithelial to Mesenchymal Transition (EMT) Process in Equine Papillomavirus-2 (EcPV-2)-Positive Penile Squamous Cell Carcinomas.. Int J Mol Sci 2021 Sep 30;22(19).
        doi: 10.3390/ijms221910588pubmed: 34638929google scholar: lookup
      4. Unger L, Abril C, Gerber V, Jagannathan V, Koch C, Hamza E. Diagnostic potential of three serum microRNAs as biomarkers for equine sarcoid disease in horses and donkeys.. J Vet Intern Med 2021 Jan;35(1):610-619.
        doi: 10.1111/jvim.16027pubmed: 33415768google scholar: lookup
      5. Saadi A, Azizi S, Farshid AA, Yousefi A. Surgical management of penile sarcoid in a stallion.. J Equine Sci 2019;30(4):99-104.
        doi: 10.1294/jes.30.99pubmed: 31871412google scholar: lookup
      6. Straticò P, Varasano V, Celani G, Suriano R, Petrizzi L. Long-Term Outcome of En Bloc Extensive Resection of the Penis and Prepuce Associated with a Permanent Perineal Urethrostomy in a Gelding Affected by Squamous Cell Carcinoma.. Case Rep Vet Med 2016;2016:6989450.
        doi: 10.1155/2016/6989450pubmed: 29955421google scholar: lookup
      7. Spugnini EP, Bolaffio C, Scacco L, Baldi A. Electrochemotherapy increases local control after incomplete excision of a recurring penile fibrosarcoma in a stallion.. Open Vet J 2016;6(3):234-237.
        doi: 10.4314/ovj.v6i3.12pubmed: 27995080google scholar: lookup
      8. Rizk A, Mosbah E, Karrouf G, Abou Alsoud M. Surgical Management of Penile and Preputial Neoplasms in Equine with Special Reference to Partial Phallectomy.. J Vet Med 2013;2013:891413.
        doi: 10.1155/2013/891413pubmed: 26464915google scholar: lookup
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