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Home / Equine Research Bank / Appl Environ Microbiol / Survey of fumonisin production by Fusarium species.
Applied and environmental microbiology1991; 57(4); 1089-1093; doi: 10.1128/aem.57.4.1089-1093.1991

Survey of fumonisin production by Fusarium species.

Abstract: Fumonisins B1 (FB1) and B2 (FB2), two structurally related mycotoxins with cancer-promoting activity, were recently isolated from corn cultures of Fusarium moniliforme MRC 826. These toxins have been reported to be produced also by isolates of F. proliferatum. Contamination of foods and feeds by F. moniliforme has been associated with human esophageal cancer risk, and FB1 has been shown to be the causative agent of the neurotoxic disease leukoencephalomalacia in horses. Because of the toxicological importance of the fumonisins, the potential to produce FB1 and FB2 was determined in a study of 40 toxic Fusarium isolates representing 27 taxa in 9 of the 12 sections of Fusarium, as well as two recently described species not yet classified into sections. With the exception of one isolate of F. nygamai, fumonisin production was restricted to isolates of F. moniliforme and F. proliferatum, in the section Liseola. The F. nygamai isolate produced 605 micrograms of FB1 g-1 and 530 micrograms of FB2 g-1, and the identity of the toxins was confirmed by capillary gas chromatography-mass spectrometry. This is the first report of the production of the fumonisins by F. nygamai.
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Publication Date: 1991-04-01 PubMed ID: 2059033PubMed Central: PMC182850DOI: 10.1128/aem.57.4.1089-1093.1991Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research targets the production of mycotoxins, specifically fumonisins B1 and B2, by various species of Fusarium fungi. The findings suggest that the capability to produce fumonisins was predominantly limited to the species Fusarium moniliforme and Fusarium proliferatum.

Background

  • Fumonisins B1 (FB1) and B2 (FB2) are mycotoxins produced by the Fusarium species of fungi. These toxins have been found in corn cultures and are associated with cancer-promoting activities.
  • These toxins, particularly FB1, have been linked to the onset of a neurotoxic disease in horses called leukoencephalomalacia, and possibly with human esophageal cancer.
  • Due to the toxicological significance of these fumonisins, the authors decided to explore the capacity of different Fusarium species to produce these toxins.

Research Method

  • The researchers conducted a study on 40 toxic Fusarium isolates representing 27 distinct taxa, spanning 9 sections of the 12 sections of Fusarium, as well as two unclassified species.
  • They measured the ability of these species to produce FB1 and FB2, and confirmed the identity of these toxins through capillary gas chromatography-mass spectrometry.

Findings

  • The results showed that the capacity to generate fumonisins was primarily limited to two particular species in the Liseola section: Fusarium moniliforme and Fusarium proliferatum.
  • One isolate of Fusarium nygamai was also found to produce fumonisins – contributing 605 micrograms of FB1 and 530 micrograms of FB2 per gram. This claim represents the first report of fumonisin production by Fusarium nygamai, an important contribution to the scientific knowledge.

Conclusion

  • This research provided important insights into the capacity of different Fusarium species to produce fumonisin B1 and B2 toxins. This is vital given the possible health implication of these toxins.
  • More specifically, the species Fusarium moniliforme, Fusarium proliferatum, and Fusarium nygamai were shown to produce these mycotoxins.
  • This discovery expands the understanding of the risk of mycotoxin contamination attributed to the Fusarium species, supporting the need for ongoing surveillance and control measures in food and feed production.

Cite This Article

APA
Thiel PG, Marasas WF, Sydenham EW, Shephard GS, Gelderblom WC, Nieuwenhuis JJ. (1991). Survey of fumonisin production by Fusarium species. Appl Environ Microbiol, 57(4), 1089-1093. https://doi.org/10.1128/aem.57.4.1089-1093.1991

Publication

Applied and environmental microbiology
ISSN: 0099-2240
NlmUniqueID: 7605801
Country: United States
Language: English
Volume: 57
Issue: 4
Pages: 1089-1093

Researcher Affiliations

Thiel, P G
  • Research Institute for Nutritional Diseases, South African Medical Research Council Tygerberg.
Marasas, W F
    Sydenham, E W
      Shephard, G S
        Gelderblom, W C
          Nieuwenhuis, J J

            MeSH Terms

            • Carcinogens, Environmental
            • Fumonisins
            • Fusarium / metabolism
            • Gas Chromatography-Mass Spectrometry
            • Mycotoxins / biosynthesis

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