FREE SHIPPING over $40
OVER 9000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
Home / Equine Research Bank / Appl Microbiol / Survey of infectious multiple drug resistance among salmonel...
Applied microbiology1971; 21(2); 358-362; doi: 10.1128/am.21.2.358-362.1971

Survey of infectious multiple drug resistance among salmonella isolated from animals in the United States.

Abstract: Salmonella cultures were obtained from outbreaks of animal disease from 37 states and 1 territory. They were screened for resistance to 11 antimicrobial drugs. Of the 1,251 strains studied, 935 were resistant to one or more of these agents. The three most common resistance patterns were ampicillin, dihydrostreptomycin, sulfamethoxypyridazine, tetracycline; ampicillin, dihydrostreptomycin, sulfamethoxypyridazine; dihydrostreptomycin, sulfamethoxypyridazine, tetracycline. Resistance transfer was demonstrated on 267 multiply resistant cultures, of which 181 were able to transfer all or part of their resistance pattern to a drug-sensitive recipient.
Get Full Text
Publication Date: 1971-02-01 PubMed ID: 5205089PubMed Central: PMC377176DOI: 10.1128/am.21.2.358-362.1971Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study explored the prevalence of drug-resistant Salmonella strains in animals across the U.S. Multiple strains of Salmonella were resistant to at least one, and often several, antimicrobial drugs; with a portion of these resistant strains capable of passing on their resistance to other organisms.

Salmonella Sample Collection

  • The researchers collected Salmonella samples from various disease outbreaks in animals across 37 American states and one territory.
  • The research focused specifically on Salmonella because it is a bacterial infection often transmitted through food, which poses a significant concern for public health.

Drug Resistance Testing

  • A total of 1,251 Salmonella strain samples were tested against 11 different antimicrobial drugs.
  • The main objective was to determine the strains’ resistance level to these drugs. Drug resistance is an alarming public health problem where bacteria change in response to the use of medicines and stop the drugs from working.
  • Out of all the samples, 935 strains were resistant to at least one or more of the tested antimicrobial agents.

Common Resistance Patterns

  • The study identified common patterns of drug resistance.
  • The three most frequently seen resistance patterns were to ampicillin, dihydrostreptomycin, sulfamethoxypyridazine, tetracycline; ampicillin, dihydrostreptomycin, sulfamethoxypyridazine; and dihydrostreptomycin, sulfamethoxypyridazine, tetracycline respectively.

Resistance Transfer

  • Particularly concerning was the finding that resistance could be transferred from one bacterial strain to another.
  • Of the 267 multiply resistant strains identified, 181 were capable of transferring all or part of their resistance to a previously drug-sensitive recipient strain.
  • Such transfer of drug resistance highlights a significant challenge in disease control strategies, as it increases the population of dangerous drug-resistant bacteria.

Conclusion

  • The study offers an essential understanding of antimicrobial resistances among Salmonella strains across the United States.
  • Findings flag the severity of the drug resistance issue in bacteria, in particular, the ability of resistant strains to pass on their resistance traits, further amplifying the problem.

Cite This Article

APA
Pocurull DW, Gaines SA, Mercer HD. (1971). Survey of infectious multiple drug resistance among salmonella isolated from animals in the United States. Appl Microbiol, 21(2), 358-362. https://doi.org/10.1128/am.21.2.358-362.1971

Publication

Applied microbiology
ISSN: 0003-6919
NlmUniqueID: 7605802
Country: United States
Language: English
Volume: 21
Issue: 2
Pages: 358-362

Researcher Affiliations

Pocurull, D W
    Gaines, S A
      Mercer, H D

        MeSH Terms

        • Ampicillin / pharmacology
        • Animals
        • Animals, Domestic
        • Anti-Bacterial Agents / pharmacology
        • Cats
        • Cattle
        • Chickens
        • Columbidae
        • Dihydrostreptomycin Sulfate / pharmacology
        • Dogs
        • Drug Synergism
        • Ducks
        • Geese
        • Genetics, Microbial
        • Horses
        • Microbial Sensitivity Tests
        • Penicillin Resistance
        • Salmonella / drug effects
        • Salmonella / isolation & purification
        • Salmonella Infections, Animal / epidemiology
        • Salmonella Infections, Animal / microbiology
        • Serotyping
        • Sheep
        • Species Specificity
        • Streptomycin / pharmacology
        • Sulfamethoxypyridazine / pharmacology
        • Swine
        • Tetracycline / pharmacology
        • Turkeys
        • United States

        References

        This article includes 22 references
        1. Anderson ES, Lewis MJ. Drug resistance and its transfer in Salmonella typhimurium.. Nature 1965 May 8;206(984):579-83.
          pubmed: 5319285doi: 10.1038/206579a0google scholar: lookup
        2. Smith HW, Halls S. Observations on infective drug resistance in Britain.. Vet Rec 1966 Mar 19;78(12):415-20.
          pubmed: 5325355doi: 10.1136/vr.78.12.415google scholar: lookup
        3. Bauer AW, Kirby WM, Sherris JC, Turck M. Antibiotic susceptibility testing by a standardized single disk method.. Am J Clin Pathol 1966 Apr;45(4):493-6.
          pubmed: 5325707
        4. Smith DH, Armour SE. Transferable R factors in enteric bacteria causing infection of the genitourinary tract.. Lancet 1966 Jul 2;2(7453):15-8.
          pubmed: 4161048doi: 10.1016/s0140-6736(66)91745-4google scholar: lookup
        5. Kabins SA, Cohen S. Resistance-transfer factor in Enterobacteriaceae.. N Engl J Med 1966 Aug 4;275(5):248-52.
          pubmed: 5943269doi: 10.1056/NEJM196608042750504google scholar: lookup
        6. Smith DH. Salmonella with transferable drug resistance.. N Engl J Med 1966 Sep 22;275(12):625-30.
          pubmed: 5178814doi: 10.1056/NEJM196609222751201google scholar: lookup
        7. Gill FA, Hook EW. Salmonella strains with transferable antimicrobial resistance.. JAMA 1966 Dec 19;198(12):1267-9.
          pubmed: 5332543
        8. Walton JR. Infectious drug resistance in Escherichia coli isolated from healthy farm animals.. Lancet 1966 Dec 10;2(7476):1300-2.
          pubmed: 4163427doi: 10.1016/s0140-6736(66)91705-3google scholar: lookup
        9. Smith HW. The incidence of infective drug resistance in strains of Escherichia coli isolated from diseased human beings and domestic animals.. Vet Rec 1967 Apr 15;80(15):464-9.
          pubmed: 5341538doi: 10.1136/vr.80.15.464google scholar: lookup
        10. Smith JP, Marymont JH Jr. Infectious drug resistance: a new and important cause of antibiotic-resistant bacteria.. J Kans Med Soc 1967 Nov;68(11):425-7.
          pubmed: 6062471
        11. Manten A, Guinée PA, Kampelmacher EH. Incidence of resistance to tetracycline and chloramphenicol among Salmonella bacteria found in the Netherlands in 1963 and in 1964.. Zentralbl Bakteriol Orig 1966 May;200(1):13-20.
          pubmed: 5995375
        12. Lewis MJ. Transferable drug resistance and other transferable agents in strains of Escherichia coli from two human populations.. Lancet 1968 Jun 29;1(7557):1389-93.
          pubmed: 4172987doi: 10.1016/s0140-6736(68)91973-9google scholar: lookup
        13. Schroeder SA, Terry PM, Bennett JV. Antibiotic resistance and transfer factor in Salmonella, United States 1967.. JAMA 1968 Sep 23;205(13):903-6.
          pubmed: 4877021
        14. Gunter AC, Feary TW. Infectious drug resistance among clinically isolated Escherichia coli.. J Bacteriol 1968 Nov;96(5):1556-61.
          pubmed: 4882016doi: 10.1128/jb.96.5.1556-1561.1968google scholar: lookup
        15. Datta N. Drug resistance and R factors in the bowel bacteria of London patients before and after admission to hospital.. Br Med J 1969 May 17;2(5654):407-11.
          pubmed: 4976456doi: 10.1136/bmj.2.5654.407google scholar: lookup
        16. Gardner P, Smith DH. Studies on the epidemiology of resistance (R) factors. I. Analysis of Klebsiella isolates in a general hospital. II. A prospective study of R factor transfer in the host.. Ann Intern Med 1969 Jul;71(1):1-9.
          pubmed: 4892967doi: 10.7326/0003-4819-71-1-1google scholar: lookup
        17. Aden DP, Reed ND, Underdahl NR, Mebus CA. Transferable drug resistance among Enterobacteriaceae isolated from cases of neonatal diarrhea in calves and piglets.. Appl Microbiol 1969 Dec;18(6):961-4.
          pubmed: 4905699doi: 10.1128/am.18.6.961-964.1969google scholar: lookup
        18. Smith HW. The transfer of antibiotic resistance between strains of enterobacteria in chicken, calves and pigs.. J Med Microbiol 1970 Feb;3(1):165-80.
          pubmed: 4915370doi: 10.1099/00222615-3-1-165google scholar: lookup
        19. MCWHORTER AC, MURRELL MC, EDWARDS PR. Resistance of salmonellae isolated in 1962 to chloretetracycline.. Appl Microbiol 1963 Jul;11(4):368-70.
          pubmed: 13932290doi: 10.1128/am.11.4.368-370.1963google scholar: lookup
        20. DATTA N. Transmissible drug resistance in an epidemic strain of Salmonella typhimurium.. J Hyg (Lond) 1962 Sep;60(3):301-10.
          pubmed: 14025218doi: 10.1017/s0022172400020416google scholar: lookup
        21. LEBEK G. [THE SPONTANEOUS LOSS OF EPISOMAL TRANSMISSIBLE MULTIPLE RESISTANCE TO ANTIBIOTICS IN POPULATIONS OF GRAM-NEGATIVE INTESTINAL MICROORGANISMS IN CULTURES WITH AND WITHOUT ANTIBIOTICS].. Z Hyg Infektionskr 1963 Oct 25;149:255-66.
          pubmed: 14095017
        22. ANDERSON ES, DATTA N. RESISTANCE TO PENICILLINS AND ITS TRANSFER IN ENTEROBACTERIACEAE.. Lancet 1965 Feb 20;1(7382):407-9.
          pubmed: 14238093doi: 10.1016/s0140-6736(65)90004-8google scholar: lookup

        Citations

        This article has been cited 5 times.
        1. Tadesse DA, Singh A, Zhao S, Bartholomew M, Womack N, Ayers S, Fields PI, McDermott PF. Antimicrobial Resistance in Salmonella in the United States from 1948 to 1995.. Antimicrob Agents Chemother 2016 Apr;60(4):2567-71.
          doi: 10.1128/AAC.02536-15pubmed: 26856840google scholar: lookup
        2. Chiou CS, Lin JM, Chiu CH, Chu CH, Chen SW, Chang YF, Weng BC, Tsay JG, Chen CL, Liu CH, Chu C. Clonal dissemination of the multi-drug resistant Salmonella enterica serovar Braenderup, but not the serovar Bareilly, of prevalent serogroup C1 Salmonella from Taiwan.. BMC Microbiol 2009 Dec 17;9:264.
          doi: 10.1186/1471-2180-9-264pubmed: 20017951google scholar: lookup
        3. McKinley GA, Fagerberg DJ, Quarles CL, George BA, Wagner DE, Rollins LD. Incidence of salmonellae in fecal samples of production swine and swine at slaughter plants in the United States in 1978.. Appl Environ Microbiol 1980 Sep;40(3):562-6.
          doi: 10.1128/aem.40.3.562-566.1980pubmed: 7425616google scholar: lookup
        4. Falbo V, Caprioli A, Mondello F, Cacace ML, Luzi S, Greco D. Antimicrobial resistance among Salmonella isolates from hospitals in Rome.. J Hyg (Lond) 1982 Apr;88(2):275-84.
          doi: 10.1017/s0022172400070133pubmed: 7061839google scholar: lookup
        5. Anderson GD, Lee DR. Salmonella in horses: a source of contamination of horsemeat in a packing plant under federal inspection.. Appl Environ Microbiol 1976 May;31(5):661-3.
          doi: 10.1128/aem.31.5.661-663.1976pubmed: 776084google scholar: lookup
        Subscribe to our newsletter
        Join 99,357 horse owners like you who receive our email updates on horse health and nutrition.