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Applied microbiology1971; 21(2); 358-362; doi: 10.1128/am.21.2.358-362.1971

Survey of infectious multiple drug resistance among salmonella isolated from animals in the United States.

Abstract: Salmonella cultures were obtained from outbreaks of animal disease from 37 states and 1 territory. They were screened for resistance to 11 antimicrobial drugs. Of the 1,251 strains studied, 935 were resistant to one or more of these agents. The three most common resistance patterns were ampicillin, dihydrostreptomycin, sulfamethoxypyridazine, tetracycline; ampicillin, dihydrostreptomycin, sulfamethoxypyridazine; dihydrostreptomycin, sulfamethoxypyridazine, tetracycline. Resistance transfer was demonstrated on 267 multiply resistant cultures, of which 181 were able to transfer all or part of their resistance pattern to a drug-sensitive recipient.
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Publication Date: 1971-02-01 PubMed ID: 5205089PubMed Central: PMC377176DOI: 10.1128/am.21.2.358-362.1971Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study explored the prevalence of drug-resistant Salmonella strains in animals across the U.S. Multiple strains of Salmonella were resistant to at least one, and often several, antimicrobial drugs; with a portion of these resistant strains capable of passing on their resistance to other organisms.

Salmonella Sample Collection

  • The researchers collected Salmonella samples from various disease outbreaks in animals across 37 American states and one territory.
  • The research focused specifically on Salmonella because it is a bacterial infection often transmitted through food, which poses a significant concern for public health.

Drug Resistance Testing

  • A total of 1,251 Salmonella strain samples were tested against 11 different antimicrobial drugs.
  • The main objective was to determine the strains’ resistance level to these drugs. Drug resistance is an alarming public health problem where bacteria change in response to the use of medicines and stop the drugs from working.
  • Out of all the samples, 935 strains were resistant to at least one or more of the tested antimicrobial agents.

Common Resistance Patterns

  • The study identified common patterns of drug resistance.
  • The three most frequently seen resistance patterns were to ampicillin, dihydrostreptomycin, sulfamethoxypyridazine, tetracycline; ampicillin, dihydrostreptomycin, sulfamethoxypyridazine; and dihydrostreptomycin, sulfamethoxypyridazine, tetracycline respectively.

Resistance Transfer

  • Particularly concerning was the finding that resistance could be transferred from one bacterial strain to another.
  • Of the 267 multiply resistant strains identified, 181 were capable of transferring all or part of their resistance to a previously drug-sensitive recipient strain.
  • Such transfer of drug resistance highlights a significant challenge in disease control strategies, as it increases the population of dangerous drug-resistant bacteria.

Conclusion

  • The study offers an essential understanding of antimicrobial resistances among Salmonella strains across the United States.
  • Findings flag the severity of the drug resistance issue in bacteria, in particular, the ability of resistant strains to pass on their resistance traits, further amplifying the problem.

Cite This Article

APA
Pocurull DW, Gaines SA, Mercer HD. (1971). Survey of infectious multiple drug resistance among salmonella isolated from animals in the United States. Appl Microbiol, 21(2), 358-362. https://doi.org/10.1128/am.21.2.358-362.1971

Publication

Applied microbiology
ISSN: 0003-6919
NlmUniqueID: 7605802
Country: United States
Language: English
Volume: 21
Issue: 2
Pages: 358-362

Researcher Affiliations

Pocurull, D W
    Gaines, S A
      Mercer, H D

        MeSH Terms

        • Ampicillin / pharmacology
        • Animals
        • Animals, Domestic
        • Anti-Bacterial Agents / pharmacology
        • Cats
        • Cattle
        • Chickens
        • Columbidae
        • Dihydrostreptomycin Sulfate / pharmacology
        • Dogs
        • Drug Synergism
        • Ducks
        • Geese
        • Genetics, Microbial
        • Horses
        • Microbial Sensitivity Tests
        • Penicillin Resistance
        • Salmonella / drug effects
        • Salmonella / isolation & purification
        • Salmonella Infections, Animal / epidemiology
        • Salmonella Infections, Animal / microbiology
        • Serotyping
        • Sheep
        • Species Specificity
        • Streptomycin / pharmacology
        • Sulfamethoxypyridazine / pharmacology
        • Swine
        • Tetracycline / pharmacology
        • Turkeys
        • United States

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        Citations

        This article has been cited 7 times.
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