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Synovial fluid D-dimer concentration in horses with osteochondritis dissecans and osteoarthritis.
Abstract: To assess the synovial fibrinolytic pathway activation in adult horses with developmental and degenerative arthropathies such as osteochondritis dissecans (OCD) and osteoarthritis (OA) by measuring synovial D-dimer concentrations. Methods: Prospective observational clinical study of horses admitted for OCD or OA. Synovial fluid was collected during lameness examination or prior to the surgical procedure, and D-dimer concentration and routine synovial fluid analysis were performed. Results: Fifty-eight horses (14 with OCD, 10 with OA and 34 controls) were included in this study. Synovial D-dimer concentrations of horses with OCD and OA were both higher when compared with controls, but were only significantly different in horses with OCD (p = 0.005). However, no statistical differences were observed when comparing synovial D-dimer concentrations from the OCD horses with the OA-affected horses (p = 0.444). Conclusions: Activation of coagulation and fibrinolysis play a role in the pathophysiology of equine OCD and OA.
Publication Date: 2012-10-29 PubMed ID: 23111710DOI: 10.3415/VCOT-11-08-0110Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
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This research study investigated the level of synovial D-dimer (a protein fragment indicating blood clotting) in horses that have osteochondritis dissecans (OCD, a joint disorder in which cracks form in the articular cartilage and the underlying subchondral bone) and osteoarthritis (OA, a type of joint disease that results from breakdown of joint cartilage and underlying bone) in order to explore the correlation between these diseases and the activation of blood coagulation and fibrinolysis.
Methodology
- The study was conducted through observational research of adult horses admitted due to OCD or OA. Other horses considered as “controls” were also part of the study.
- Synovial fluid (a viscous, non-Newtonian fluid found in the cavities of synovial joints) was collected from all the horses either during the examination of lameness or before any surgical procedures.
- D-dimer concentration and routine synovial fluid analysis were done on all collected samples.
Results
- A total of 58 horses were included in the study: 14 with OCD, 10 with OA, and 34 as controls.
- The study found that the D-dimer levels in the synovial fluid of horses with OCD and OA were higher than those in the control group. This difference was, however, only statistically significant in the OCD group.
- When comparing the D-dimer levels between the OCD and OA groups, no statistically significant difference was observed.
Conclusion
- The findings from this research suggest that blood coagulation and fibrinolysis – processes involved in the formation and dissolution of blood clots respectively – potentially contribute to the pathophysiology (study of the functioning of diseased organisms) of both equine OCD and OA.
- This implies that D-dimer concentration could be further explored as a biomarker for these conditions, particularly in assessing the severity or progression of the diseases, as well as in the potential development of treatment strategies.
Cite This Article
APA
Ribera T, Monreal L, Delgado MA, Ríos J, Prades M.
(2012).
Synovial fluid D-dimer concentration in horses with osteochondritis dissecans and osteoarthritis.
Vet Comp Orthop Traumatol, 26(1), 54-60.
https://doi.org/10.3415/VCOT-11-08-0110 Publication
Researcher Affiliations
- Servei de Cirurgia Equina, Departament de Medicina i Cirurgia Animals, Universitat Autònoma de Barcelona, Spain. Thais.Ribera@uab.cat
MeSH Terms
- Animals
- Biomarkers
- Female
- Fibrin Fibrinogen Degradation Products / chemistry
- Fibrin Fibrinogen Degradation Products / metabolism
- Horse Diseases / metabolism
- Horses
- Logistic Models
- Male
- Osteoarthritis / metabolism
- Osteoarthritis / veterinary
- Osteochondritis Dissecans / metabolism
- Osteochondritis Dissecans / veterinary
- Synovial Fluid / chemistry
Citations
This article has been cited 3 times.- Andreassen SM, Vinther AML, Nielsen SS, Andersen PH, Tnibar A, Kristensen AT, Jacobsen S. Changes in concentrations of haemostatic and inflammatory biomarkers in synovial fluid after intra-articular injection of lipopolysaccharide in horses. BMC Vet Res 2017 Jun 19;13(1):182.
- Barton AK, Wirth C, Bondzio A, Einspanier R, Gehlen H. Are pulmonary hemostasis and fibrinolysis out of balance in equine chronic pneumopathies?. J Vet Sci 2017 Sep 30;18(3):349-357.
- Andreassen SM, Berg LC, Nielsen SS, Kristensen AT, Jacobsen S. mRNA expression of genes involved in inflammation and haemostasis in equine fibroblast-like synoviocytes following exposure to lipopolysaccharide, fibrinogen and thrombin. BMC Vet Res 2015 Jun 27;11:141.
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