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Animals : an open access journal from MDPI2022; 12(22); doi: 10.3390/ani12223124

Systematic Review of Complementary and Alternative Veterinary Medicine in Sport and Companion Animals: Extracorporeal Shockwave Therapy.

Abstract: Extracorporeal shockwave therapy (ECSWT) is increasingly used to treat different types of musculoskeletal conditions in sport and companion animals. To explore the scientific basis for the treatment, we conducted a systematic review of the literature on ECSWT used in horses, dogs, and cats. Methods: Relevant articles published in 1980-2020 were identified from three major databases. Each article was assessed for risk of bias. Results: The review identified 27 relevant articles on the effects of ECSWT in horses, nine in dogs, but none in cats. Typically, ECSWT involved one to three treatment sessions at 1- to 3-week intervals. We identified studies on bone mass and bone healing, wound healing, navicular disease, ligament injury, desmitis, sesamoiditis, tendon injury, osteoarthritis, and short-term analgesic effects. Common to all indications was that the scientific evidence was very limited. For each separate indication, there were relatively few studies, many of which had methodological flaws. Where favorable results were reported, they were usually not replicated in independent studies. A few encouraging results were found. Conclusions: In sport and companion animals, the scientific evidence for clinical effects of ECSWT in horses, dogs, and cats is limited. For some applications, notably short-term pain relief, ligament ailments, and osteoarthritis, the results seem promising and warrant further exploration in high-quality studies.
Publication Date: 2022-11-12 PubMed ID: 36428352PubMed Central: PMC9686741DOI: 10.3390/ani12223124Google Scholar: Lookup
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  • Journal Article
  • Review

Summary

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This research article delves into the exploration of Extracorporeal shockwave therapy (ECSWT) as a treatment for various musculoskeletal conditions in companion and sport animals, specifically horses and dogs. Despite an increasing usage of this method, the article concludes that there is a lack of significant scientific evidence to back up its effectiveness due to, for instance, methodological flaws in studies.

Research Methodology

  • The study was conducted as a systematic review, involving a thorough search for relevant literature from three major databases.
  • The time frame considered for the literature was from 1980-2020.
  • The focus was on articles that explored the use of ECSWT on horses, dogs, and cats.
  • In order to ensure the credibility of the material reviewed, each article was evaluated for potential bias risks.

Research Findings

  • The systematic review found 27 relevant articles related to the effects of ECSWT in horses, and nine with regards to dogs. There were, however, no such articles addressing its impact on cats.
  • In general, the application of ECSWT typically comprised of one to three treatment sessions conducted at 1- to 3-week intervals.
  • Various studies were found that examine ECSWT’s effects on different medical conditions such as bone mass healing, wound healing, navicular disease, ligament injury, desmitis, sesamoiditis, tendon injury, osteoarthritis, and short-term analgesic effects.
  • Yet, across all these applications, there was a noticeable dearth of strong scientific evidence to validate the therapy.
  • Additionally, the studies concerning each separate indication were limited and many of them were identified as having methodological flaws. Successful outcomes reported in some instances were generally not replicated in other independent studies.

Research Conclusions

  • In spite of the low volume of concrete scientific evidence supporting the clinical effects of ECSWT in horses, dogs, and cats, the authors note that there were a few encouraging findings.
  • The most promising results were discovered in relation to short-term pain relief, ligament ailments, and osteoarthritis.
  • However, the authors suggest further investigation through high-quality studies to solidify these initial findings.

Cite This Article

APA
Boström A, Bergh A, Hyytiäinen H, Asplund K. (2022). Systematic Review of Complementary and Alternative Veterinary Medicine in Sport and Companion Animals: Extracorporeal Shockwave Therapy. Animals (Basel), 12(22). https://doi.org/10.3390/ani12223124

Publication

ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 12
Issue: 22

Researcher Affiliations

Boström, Anna
  • Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, P.O. Box 57, 00014 Helsinki, Finland.
Bergh, Anna
  • Department of Clinical Sciences, Swedish University of Agricultural Sciences, SE 750 07 Uppsala, Sweden.
Hyytiäinen, Heli
  • Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, P.O. Box 57, 00014 Helsinki, Finland.
Asplund, Kjell
  • Department of Public Health and Clinical Medicine, Umeå University, SE 901 87 Umeå, Sweden.

Grant Funding

  • SLU.ua.2020.4.2-3148 / SLU Future One Health, Swedish University of Agricultural Sciences

Conflict of Interest Statement

The authors have no conflicts of interest to declare.

References

This article includes 45 references
  1. Chamberlain G.A., Colborne G.R.. A review of the cellular and molecular effects of extracorporeal shockwave therapy.. Vet. Comp. Orthop. Traumatol. 2016;29:99–107.
    doi: 10.3415/VCOT-15-04-0057pubmed: 26846274google scholar: lookup
  2. MacKay A.V., McOnie R.C., Riddell L.P., Robinson K.A.. Characterization of the use of shock wave therapy among equine veterinarians.. Can. Vet. J. 2020;61:990–993.
    pmc: PMC7424940pubmed: 32879526
  3. Yocom A.F., Bass L.D.. Review of the application and efficacy of extracorporeal shockwave therapy in equine tendon and ligament injuries.. Equine Vet. Educ. 2019;31:271–277.
    doi: 10.1111/eve.12780google scholar: lookup
  4. Hiller S.C., Ghani K.R.. Frontiers of stone management.. Curr. Opin. Urol. 2020;30:17–23.
    doi: 10.1097/MOU.0000000000000698pubmed: 31725002google scholar: lookup
  5. Bergh A., Lund I., Boström A., Hyytiäinen H., Asplund K.. A systematic review of complementary and alternative veterinary medicine: “Miscellaneous therapies”.. Animals 2021;11:3356.
    doi: 10.3390/ani11123356pmc: PMC8697896pubmed: 34944133google scholar: lookup
  6. . SBU:s Metodbok.. 2022.
  7. Higgins J., Thomas J.. Cochrane Handbook for Systematic Reviews of Interventions, Version 6.2.. 2021.
  8. Urhahne P., Röcken M., Gerhards H.. Eine klinische Studie zur Behandlung häufiger Erkrankungen des Bewegungsapparates des Pferdes mittels fokussierter extrakorporaler Stoßwellentherapie (ESWT). Pfederheilkunde 2005;21:545–550.
  9. Johannes E.J., Kaulesar Sukul D.M.K.S., Matura E.. High-energy shock waves for the treatment of nonunions: An experiment on dogs.. J. Surg. Res. 1994;57:246–252.
    doi: 10.1006/jsre.1994.1139pubmed: 8028332google scholar: lookup
  10. Pyles M.D., da Fonseca B.P.A., Machado V.M.V., Alves A.L.G.. Determinação da densidade mineral e da elasticidade óssea após a aplicação de ondas de choque extracorpóreas no terceiro metacarpiano de equinos atletas.. Braz. J. Vet. Tes. Anim. Sci. 2011;48:495–502.
  11. Ringer S.K., Lischer C.J., Ueltschi G.. Assessment of scintigraphic and thermographic changes after focused extracorporeal shock wave therapy on the origin of the suspensory ligament and the fourth metatarsal bone in horses without lameness.. Am. J. Vet. Res. 2005;66:1836–1842.
    doi: 10.2460/ajvr.2005.66.1836pubmed: 16273919google scholar: lookup
  12. Link K.A., Koenig J.B., Silveira A., Plattner B.L., Lillie B.N.. Effect of unfocused extracorporeal shock wave therapy on growth factor gene expression in wounds and intact skin of horses.. Am. J. Vet. Res. 2013;74:324–332.
    doi: 10.2460/ajvr.74.2.324pubmed: 23363361google scholar: lookup
  13. Morgan D.D., McClure S., Yaeger M.J., Schumacher J., Evans R.B.. Effects of extracorporeal shock wave therapy on wounds of the distal portion of the limbs in horses.. J. Am. Vet. Med. Assoc. 2009;234:1154–1161.
    doi: 10.2460/javma.234.9.1154pubmed: 19405886google scholar: lookup
  14. Silveira A., Koenig J.B., Arroyo L.G., Trout D., Moens N.M., LaMarre J., Brooks A.. Effects of unfocused extracorporeal shock wave therapy on healing of wounds of the distal portion of the forelimb in horses.. Am. J. Vet. Res. 2010;71:229–234.
    doi: 10.2460/ajvr.71.2.229pubmed: 20113232google scholar: lookup
  15. Blum N., Kreling K., Öitzke L.-F.. Der Einsatz der Extrakorporalen Stoßwellentherapie zur Behandlung des Podotrochlose-Syndroms.. Pferdeheilkunde 2005;21:29–38.
    doi: 10.21836/PEM20050104google scholar: lookup
  16. Brown K.E., Nickels F.A., Caron J.P., Mullineaux D.R., Clayton H.M.. Investigation of the immediate analgesic effects of extracorporeal shock wave therapy for treatment of navicular disease in horses.. Vet. Surg. 2005;34:554–558.
  17. Byron C., Stewart A., Benson B., Tennent-Brown B., Foreman J.. Effects of radial extracorporeal shock wave therapy on radiographic and scintigraphic outcomes in horses with palmar heel pain.. Vet. Comp. Orthop. Traumatol. 2009;22:113–118.
    pubmed: 19290391
  18. Caminoto E.H., Alves A.L., Amorim R.L., Thomassian A., Hussni C.A., Nicoletti J.L.. Ultrastructural and immunocytochemical evaluation of the effects of extracorporeal shock wave treatment in the hind limbs of horses with experimentally induced suspensory ligament desmitis.. Am. J. Vet. Res. 2005;66:892–896.
    doi: 10.2460/ajvr.2005.66.892pubmed: 15934618google scholar: lookup
  19. Giunta K., Donnell J.R., Donnell A.R., Frisbie D.D.. Prospective randomized comparison of platelet rich plasma to extracorporeal shockwave therapy for treatment of proximal suspensory pain in western performance horses.. Res. Vet. Sci. 2019;126:38–44.
    doi: 10.1016/j.rvsc.2019.07.020pubmed: 31430578google scholar: lookup
  20. Siedler C., Stanek C., Brems R.. Proximal suspensory desmitis in the horse: Extracorporeal shock wave therapy compared to injections according to Dr. Muller-Wohlfahrt. A field study.. Tierärtzl. Prax. 2003;31:342–351.
  21. Crowe O.M., Dyson S.J., Wright L.M., Schramme M.C., Smith R.K.W.. Treatment of chronic or recurrent proximal suspensory desmitis using radial pressure wave therapy in the horse.. Equine Vet. J. 2004;36:313–316.
    doi: 10.2746/0425164044890562pubmed: 15163037google scholar: lookup
  22. Lischer C.J., Ringer S.K., Schnewlin M., Imboden I., Fürst A., Stöckli M., Auer J.. Treatment of chronic proximal suspensory desmitis in horses using focused electrohydraulic shockwave therapy.. Schweiz. Arch. Tierheilk. 2006;148:561–568.
    doi: 10.1024/0036-7281.148.10.561pubmed: 17076464google scholar: lookup
  23. Löffeld S., Boening K.-J., Weirkamp K., Stadlwer P.. Radiale extrakorporale Stoßwellentherapie® bei Pferden mit chronischer Insertionsdesmopathie am Fesselträgerursprung– eine kontrollierte Studie.. Pferdeheilkunde 2002;18:147–154.
    doi: 10.21836/PEM20020203google scholar: lookup
  24. Bosch G., de Mos M., van Binsbergen R., van Schie H.T., van de Lest C.H., van Weeren P.R.. The effect of focused extracorporeal shock wave therapy on collagen matrix and gene expression in normal tendons and ligaments.. Equine Vet. J. 2009;41:335–341.
    doi: 10.2746/042516409X370766pubmed: 19562893google scholar: lookup
  25. Bosch G., Lin Y.L., van Schie H.T., van De Lest C.H., Barneveld A., van Weeren P.R.. Effect of extracorporeal shock wave therapy on the biochemical composition and metabolic activity of tenocytes in normal tendinous structures in ponies.. Equine Vet. J. 2007;39:226–231.
    doi: 10.2746/042516407X180408pubmed: 17520973google scholar: lookup
  26. Hunter J., McClure S.R., Merritt D.K., Reinertson E.. Extracorporeal shockwave therapy for treatment of superficial digital flexor tendonitis in racing Thoroughbreds: 8 clinical cases.. Vet. Comp. Orthop. Traumatol. 2004;17:152–155.
    doi: 10.1055/s-0038-1632804google scholar: lookup
  27. Frisbie D.D., Kawcak C.E., McIlwraith C.W.. Evaluation of the effect of extracorporeal shock wave treatment on experimentally induced osteoarthritis in middle carpal joints of horses.. Am. J. Vet. Res. 2009;70:449–454.
    doi: 10.2460/ajvr.70.4.449pubmed: 19335099google scholar: lookup
  28. Kawcak C.E., Frisbie D.D., McIlwraith C.W.. Effects of extracorporeal shock wave therapy and polysulfated glycosaminoglycan treatment on subchondral bone, serum biomarkers, and synovial fluid biomarkers in horses with induced osteoarthritis.. Am. J. Vet. Res. 2011;72:772–779.
    doi: 10.2460/ajvr.72.6.772pubmed: 21627523google scholar: lookup
  29. McCarroll G.D., McClure S.R.. Initial experiences with extracorporeal shock wave therapy for treatment of bone spavin in horses—Part II.. Vet. Comp. Orthop. Traumatol. 2002;15:184–186.
    doi: 10.1055/s-0038-1632735google scholar: lookup
  30. Bolt D.M., Burba D.J., Hubert J.D., Strain G.M., Hosgood G.L., Henk W.G., Cho D.Y.. Determination of functional and morphologic changes in palmar digital nerves after nonfocused extracorporeal shock wave treatment in horses.. Am. J. Vet. Res. 2004;65:1714–1718.
    doi: 10.2460/ajvr.2004.65.1714pubmed: 15631039google scholar: lookup
  31. Bolt D.M., Burba D.J., Hubert J.D., Pettifer G.R., Hosgood G.L.. Evaluation of cutaneous analgesia after non-focused extracorporeal shock wave application over the 3rd metacarpal bone in horses.. Can. J. Vet. Res. 2004;68:288–292.
    pmc: PMC1111360pubmed: 15581224
  32. Waldern N.M., Weishaupt M.A., Imboden I., Wiestner T., Lischer C.J.. Evaluation of skin sensitivity after shock wave treatment in horses.. Am. J. Vet. Res. 2005;66:2095–2100.
    doi: 10.2460/ajvr.2005.66.2095pubmed: 16379653google scholar: lookup
  33. Trager I.R., Funk R.A., Clapp K.S., Dahlgren L.A., Werre S.L., Hodgson D.R., Pleasant R.S.. Extracorporeal shockwave therapy raises mechanical nociceptive threshold in horses with thoracolumbar pain.. Equine Vet. J. 2020;52:250–257.
    doi: 10.1111/evj.13159pubmed: 31393628google scholar: lookup
  34. Alves A.L.G., Almeida da Fonseca B.P., Hussni C.A., Soares L.V.. Tratamento da desmite supra e interespinhosa em equinos utilizando a terapia por ondas de choque extracorpóreas.. Vet. Zootec. 2009;18:143–151.
  35. Dahlberg J.A., McClure S.R., Evans R.B., Reinertson E.L.. Force platform evaluation of lameness severity following extracorporeal shock wave therapy in horses with unilateral forelimb lameness.. J. Am. Vet. Med. Assoc. 2006;229:100–103.
    doi: 10.2460/javma.229.1.100pubmed: 16817722google scholar: lookup
  36. Barnes K., Faludi A., Takawira C., Aulakh K., Rademacher N., Liu C.C., Lopez M.J.. Extracorporeal shock wave therapy improves short-term limb use after canine tibial plateau leveling osteotomy.. Vet. Surg. 2019;48:1382–1390.
    doi: 10.1111/vsu.13320pubmed: 31469432google scholar: lookup
  37. Barnes K., Lanz O., Were S., Clapp K., Gilley R.. Comparison of autogenous cancellous bone grafting and extracorporeal shock wave therapy on osteotomy healing in the tibial tuberosity advancement procedure in dogs. Radiographic densitometric evaluation.. Vet. Comp. Orthop. Traumatol. 2015;28:207–214.
    pubmed: 25899991
  38. Kieves N.R., MacKay C.S., Adducci K., Rao S., Goh C., Palmer R.H., Duerr F.M.. High energy focused shock wave therapy accelerates bone healing. A blinded, prospective, randomized canine clinical trial.. Vet. Comp. Orthop. Traumatol. 2015;28:425–432.
    doi: 10.3415/VCOT-15-05-0084pubmed: 26449666google scholar: lookup
  39. Gallagher A., Cross A.R., Sepulveda G.. The effect of shock wave therapy on patellar ligament desmitis after tibial plateau leveling osteotomy.. Vet. Surg. 2012;41:482–485.
  40. Leeman J.J., Shaw K.K., Mison M.B., Perry J.A., Carr A., Shultz R.. Extracorporeal shockwave therapy and therapeutic exercise for supraspinatus and biceps tendinopathies in 29 dogs.. Vet. Rec. 2016;179:385.
    doi: 10.1136/vr.103487pubmed: 27444781google scholar: lookup
  41. Dahlberg J.A., Fitch G., Evans R.B., McClure S.R., Conzemius M.. The evaluation of extracorporeal shockwave therapy in naturally occurring osteoarthritis of the stifle joint in dogs.. Vet. Comp. Orthop. Traumatol. 2005;18:147–152.
    pubmed: 16594445
  42. Mueller M., Bockstahler B., Salicky M., Mlacnik E., Lorinson D.. Effects of radial shockwave therapy on the limb function of dogs with hip osteoarthritis.. Vet. Rec. 2007;160:762–765.
    doi: 10.1136/vr.160.22.762pubmed: 17545646google scholar: lookup
  43. Bockstahler B., Müller M., Skalicky M., Mlacnik E., Lorinson D.. Die extrakorporale radiale Stoßwellentherapie bei der Cubarthrose des Hundes-eine mittels Messung von Bodenreaktionskräften evaluierte Studie.. Tierärzl. Mschr. 2006;93:39–46.
  44. Loghlin M., Lewith G., Falkenberg T.. Science, practice and mythology: A definition and examination of the implications of scientism in medicine.. Health Care Anal. 2013;21:130–145.
    doi: 10.1007/s10728-012-0211-6pubmed: 22622355google scholar: lookup
  45. Simplicio C.L., Purita J., Murrell W., Santos G.S., Dos Santos R.G., Lana J.. Extracorporeal shock wave therapy mechanisms in musculoskeletal regenerative medicine.. J. Clin. Orthop. Trauma. 2020;11((Suppl. S3)):S309–S318.
    doi: 10.1016/j.jcot.2020.02.004pmc: PMC7275282pubmed: 32523286google scholar: lookup