Systemic or intrasynovial medication as singular or as combination treatment in horses with (peri-)synovial pain.
Abstract: Records of lame horses (2004-2007) with (peri-)synovial pain of the metacarpophalangeal joint (MCPJ, n = 53), digital flexor tendon sheath (DFTS, n = 20), and distal interphalangeal joint (DIPJ, n = 31) were evaluated (n = 104). Cases were grouped according to the following treatments: (1) systemic administration of NSAIDs (n = 40); (2) intrasynovial administration of glucocorticosteroids (n = 30); (3) combination treatment (n = 34). Outcome was defined as successful when the owner reported that the horse had returned to its previous level of performance within a period of up to six months after treatment. Statistical evaluation was performed using Fisher's Exact tests and multivariable logistic regression analyses at P < 0.05. Successful outcome was significantly higher for horses in treatment group 3 (19/34, 55.9 per cent, P = 0.021) than in treatment groups 1 (11/40, 27.5 per cent, OR 0.21, 95 per cent CI 0.06 to 0.71) and 2 (8/30, 26.6 per cent, OR 0.18, 95 per cent CI 0.06 to 0.56). A significant association was only found with regard to the affected synovial structure (P = 0.025); relative to the DIPJ, involvement of the MCPJ and DFTS was four to five times more likely to provide a successful outcome (OR 4.18 and 5.59, 95 per cent CI 1.24 to 14.08 and 1.42-22.22, respectively).
Publication Date: 2012-10-23 PubMed ID: 23092972DOI: 10.1136/vr.100811Google Scholar: Lookup
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- Journal Article
Summary
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The research article focuses on the outcomes of three different treatment approaches for lameness in horses related to synovial pain. Treatment strategies included systemic NSAIDs, intrasynovial glucocorticosteroids, or a combination of the two. The most effective treatment turned out to be the combination approach, with the site of pain also significantly impacting the success rate.
Study Details
- The paper investigates treatment records of 104 horses with synovial pain, each of these records dating between 2004 – 2007.
- These horses had synovial pain in the metacarpophalangeal joint (MCPJ), digital flexor tendon sheath (DFTS), or distal interphalangeal joint (DIPJ).
- The study categorized these cases based on three distinct treatment methods: Group 1 where horses received systemic NSAIDs (n = 40), Group 2 where horses were given intrasynovial glucocorticosteroids (n = 30), and Group 3 where horses received a combination treatment of the previous two methods (n = 34).
Defining Success of Treatment
- For the purposes of this research, a successful treatment outcome was defined as the horse’s ability to return to its previous level of physical performance within six months post-treatment.
Statistical Analysis and Results
- Outcomes were analyzed using Fisher’s Exact tests and multivariable logistic regression analyses.
- The results showed a significantly higher successful outcome for horses in the combination treatment group (55.9%) compared to the other two groups.
- Within Group 1 (systemic NSAIDs only), only 27.5% showed successful treatment outcomes while in Group 2 (intrasynovial glucocorticosteroids only), a mere 26.6% showed successful outcomes.
- Moreover, the odds of successful treatment were found to be significantly lower in Groups 1 and 2 versus Group 3, indicating the superior efficacy of the combination treatment.
- Only the site of synovial pain had a significant impact on the treatment outcome. It was found that, relative to the DIPJ, the MCPJ and DFTS were four to five times more likely to yield successful outcomes.
Cite This Article
APA
Brommer H, Schipper P, Barneveld A, van Weeren PR.
(2012).
Systemic or intrasynovial medication as singular or as combination treatment in horses with (peri-)synovial pain.
Vet Rec, 171(21), 527.
https://doi.org/10.1136/vr.100811 Publication
Researcher Affiliations
- Department of Equine Sciences, Faculty of Veterinary Medicine, University of Utrecht, Yalelaan 112-114, Utrecht NL-3584 CM, The Netherlands. H.Brommer@uu.nl
MeSH Terms
- Animals
- Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
- Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
- Drug Administration Routes / veterinary
- Drug Therapy, Combination / veterinary
- Female
- Glucocorticoids / administration & dosage
- Glucocorticoids / therapeutic use
- Horse Diseases / drug therapy
- Horses
- Lameness, Animal / drug therapy
- Male
- Pain / drug therapy
- Pain / veterinary
- Retrospective Studies
- Treatment Outcome
Citations
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