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Home / Equine Research Bank / Vet Med Sci / TamaFlex™-A novel nutraceutical blend improves lamene...
Veterinary medicine and science2022; 8(5); 1936-1945; doi: 10.1002/vms3.894

TamaFlex™-A novel nutraceutical blend improves lameness and joint functions in working horses.

Abstract: Lameness is one of the major causes of reduced physical performance and early retirement in working horses. TamaFlex™ (NXT15906F6) is a standardized synergistic anti-inflammatory botanical formulation containing Tamarindus indica seed extract and Curcuma longa rhizome extract at a 2:1 ratio. We conducted a 12-week single-center, randomized, blinded, placebo-controlled trial demonstrating the efficacy of NXT15906F6 in horses with lameness grade 2-4 on the American Association of Equine Practitioners (AAEP) scale. Twenty-two lame horses were supplemented with NXT15906F6 (2.5 gram/day) or placebo over a period of 84 days. Improvement in lameness over placebo was the primary endpoint, and changes in the levels of rheumatoid factor (RF), anti-nuclear antibody (ANA), and anti-cyclic citrullinated peptide (ACC-peptide) in serum, and pro-inflammatory cytokines including interleukin (IL-1β and IL-6), tumor necrosis factor-α (TNF-α) and prostaglandin-E (PGE ) in serum and synovial fluid were the secondary endpoints. NXT15906F6 exhibited significant relief from lameness in a time-dependent manner. NXT15906F6 also reduced levels of ANA, PGE , IL-1β, TNF-α and IL-6. Moreover, NXT15906F6 supplementation is safe and tolerable in alleviating joint pain in lame horses, and protects the joints from further degradation by reducing pro-inflammatory mediators. NXT15906F6 significantly reduces the lameness during walking and trotting, leading to an improvement in their joint flexibility, health, and working performances.
© 2022 The Authors. Veterinary Medicine and Science published by John Wiley & Sons Ltd.
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Publication Date: 2022-07-29 PubMed ID: 35905197PubMed Central: PMC9514497DOI: 10.1002/vms3.894Google Scholar: Lookup
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  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study presents the results of a clinical trial on a nutraceutical formulation, TamaFlex™, showing its effectiveness in reducing lameness and improving joint functionality in horses. The formulation also showed potential benefits in alleviating joint pain and inhibiting inflammation.

Research Context

  • Lameness, a mobility impairment usually resulting from joint issues, is a significant health problem in working horses, often leading to early retirement.
  • There is thus a need for treatments that can mitigate lameness and improve joint health in these animals.
  • The researchers carried out a study on a nutraceutical product called TamaFlex™, which contains extract from the seed of Tamarindus indica and the rhizome of Curcuma longa. This blend was specifically selected for its anti-inflammatory properties.

Methodology

  • The researchers conducted a single-center, randomized, blinded, placebo-controlled trial over a 12-week period.
  • They studied 22 horses suffering from varying degrees of lameness (graded 2-4 on the AAEP scale).
  • The horses were either given a TamaFlex™ supplement (2.5 grams a day) or a placebo for 84 days.
  • The primary endpoint was the reduction in lameness. Secondary endpoints included levels of rheumatoid factor (RF), anti-nuclear antibody (ANA), and anti-cyclic citrullinated peptide (ACC-peptide) in serum, along with pro-inflammatory markers in both serum and synovial fluid (IL-1β, IL-6, TNF-α, and PGE).

Findings and Implications

  • The results of the trial indicated a significant time-dependent reduction in lameness among the horses receiving the TamaFlex™ supplement compared to the placebo group.
  • Additionally, TamaFlex™ contributed to reducing levels of pro-inflammatory markers and immune system components including ANA, PGE, IL-1β, TNF-α, and IL-6.
  • This suggests that in addition to improving mobility, the supplement may help to relieve joint pain and prevent further joint degradation.
  • Overall, this study indicates that TamaFlex™ may be an effective supplement for working horses, improving joint health and functionality and reducing lameness.

Cite This Article

APA
Jain S, Patil SG, Chinta G, Alluri KV. (2022). TamaFlex™-A novel nutraceutical blend improves lameness and joint functions in working horses. Vet Med Sci, 8(5), 1936-1945. https://doi.org/10.1002/vms3.894

Publication

Veterinary medicine and science
ISSN: 2053-1095
NlmUniqueID: 101678837
Country: England
Language: English
Volume: 8
Issue: 5
Pages: 1936-1945

Researcher Affiliations

Jain, Sandesh
  • Vins Bioproducts Ltd., Hyderabad, Telangana, India.
Patil, Satyajit G
  • Laila Nutraceuticals R & D Centre, Vijayawada, Andhra Pradesh, India.
Chinta, Gopichand
  • Laila Nutraceuticals R & D Centre, Vijayawada, Andhra Pradesh, India.
Alluri, KrishnaRaju Venkata
  • Laila Nutraceuticals R & D Centre, Vijayawada, Andhra Pradesh, India.

MeSH Terms

  • Animals
  • Anti-Inflammatory Agents
  • Cytokines / therapeutic use
  • Dietary Supplements
  • Horse Diseases / drug therapy
  • Horse Diseases / metabolism
  • Horses
  • Inflammation Mediators / therapeutic use
  • Interleukin-6
  • Lameness, Animal / drug therapy
  • Lameness, Animal / prevention & control
  • Plant Extracts / therapeutic use
  • Prostaglandins / therapeutic use
  • Prostaglandins E / therapeutic use
  • Rheumatoid Factor
  • Tumor Necrosis Factor-alpha

Conflict of Interest Statement

The authors declare the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Satyjit G. Patil, Gopichand Chinta, and KrishnaRaju Venkata Alluri are the employees of Laila Nutraceuticals R&D entre, Vijayawada. Sandesh Jain is the employee of Vins Bioproducts Ltd, Hyderabad, Telangana.

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Citations

This article has been cited 1 times.
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