The anamnestic serologic response to vaccination with a canarypox virus-vectored recombinant West Nile virus (WNV) vaccine in horses previously vaccinated with an inactivated WNV vaccine.
Abstract: A new recombinant West Nile virus (WNV) vaccine has been licensed for use in horses. Prior to the availability of the recombinant vaccine in 2004, the only equine WNV vaccine available on the market had been an inactivated vaccine. Since the recombinant vaccine only expresses selected viral genes, the question could be posed as to whether a single dose of the recombinant vaccine would be effective in producing an anamnestic serologic response in horses previously vaccinated with an inactivated WNV vaccine. In this study we demonstrate that vaccination of horses with a canarypox-vectored recombinant vaccine, under field conditions, results in a marked anamnestic response in horses previously vaccinated with an inactivated WNV vaccine.
Publication Date: 2005-02-19 PubMed ID: 15719324
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This research article examines how horses previously vaccinated with an inactivated West Nile virus (WNV) vaccine respond to a new recombinant WNV vaccine. The study shows that the recombinant vaccine, when applied under field conditions, triggers a strong immune response in horses.
Introduction to the Research Topic
- The research focuses on a new recombinant West Nile Virus (WNV) vaccine that has been licensed for use in horses.
- Before the advent of the recombinant vaccine, the only available WNV vaccine for horses was an inactivated version.
The Research Problem and Objective
- The recombinant vaccine only expresses selected viral genes.
- As such, it was not known how a single dose of the recombinant vaccine would impact horses that had been previously vaccinated with the inactivated WNV vaccine.
- The objective of the research was therefore to find out whether the recombinant vaccine would trigger an anamnestic serologic response in such horses.
Methodology
- The research involved vaccinating horses under field conditions with the canarypox-vectored recombinant vaccine.
- These horses had all been previously vaccinated with an inactivated WNV vaccine.
Results and Conclusion
- The study found that the recombinant vaccine did indeed result in a significant anamnestic response in the horses.
- Thus, it concluded that the new recombinant WNV vaccine is effective in creating an immune response in horses previously vaccinated with an inactivated WNV vaccine.
Implications of the Study
- The findings of this research are beneficial in the overall understanding of immunological responses to different types of vaccines.
- They could also potentially impact the vaccination strategies for West Nile Virus among equine populations.
- Finally, these results might carry broader implications for the use of recombinant versus inactivated vaccines in other species as well.
Cite This Article
APA
Grosenbaugh DA, Backus CS, Karaca K, Minke JM, Nordgren RM.
(2005).
The anamnestic serologic response to vaccination with a canarypox virus-vectored recombinant West Nile virus (WNV) vaccine in horses previously vaccinated with an inactivated WNV vaccine.
Vet Ther, 5(4), 251-257.
Publication
Researcher Affiliations
- Merial Limited, 115 Transtech Drive, Athens, GA, 30601, USA.
MeSH Terms
- Animals
- Antibodies, Viral / blood
- Canarypox virus / genetics
- Female
- Horse Diseases / prevention & control
- Horses
- Male
- Random Allocation
- Vaccines, Inactivated / immunology
- Vaccines, Synthetic / immunology
- Viral Vaccines / immunology
- Viremia / veterinary
- West Nile Fever / prevention & control
- West Nile Fever / veterinary
- West Nile virus / immunology
Citations
This article has been cited 5 times.- Qin F, Xia F, Chen H, Cui B, Feng Y, Zhang P, Chen J, Luo M. A Guide to Nucleic Acid Vaccines in the Prevention and Treatment of Infectious Diseases and Cancers: From Basic Principles to Current Applications.. Front Cell Dev Biol 2021;9:633776.
- Iyer AV, Kousoulas KG. A review of vaccine approaches for West Nile virus.. Int J Environ Res Public Health 2013 Sep 10;10(9):4200-23.
- Iyer AV, Pahar B, Boudreaux MJ, Wakamatsu N, Roy AF, Chouljenko VN, Baghian A, Apetrei C, Marx PA, Kousoulas KG. Recombinant vesicular stomatitis virus-based west Nile vaccine elicits strong humoral and cellular immune responses and protects mice against lethal challenge with the virulent west Nile virus strain LSU-AR01.. Vaccine 2009 Feb 5;27(6):893-903.
- Bonafé N, Rininger JA, Chubet RG, Foellmer HG, Fader S, Anderson JF, Bushmich SL, Anthony K, Ledizet M, Fikrig E, Koski RA, Kaplan P. A recombinant West Nile virus envelope protein vaccine candidate produced in Spodoptera frugiperda expresSF+ cells.. Vaccine 2009 Jan 7;27(2):213-22.
- Seino KK, Long MT, Gibbs EP, Bowen RA, Beachboard SE, Humphrey PP, Dixon MA, Bourgeois MA. Comparative efficacies of three commercially available vaccines against West Nile Virus (WNV) in a short-duration challenge trial involving an equine WNV encephalitis model.. Clin Vaccine Immunol 2007 Nov;14(11):1465-71.
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