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Medical hypotheses2003; 60(4); 481-483; doi: 10.1016/s0306-9877(02)00377-8

The Australian paralysis tick may be the missing link in the transmission of Hendra virus from bats to horses to humans.

Abstract: Hendra virus is a new virus of the family Paramyxoviridae. This virus was first detected in Queensland, Australia, in 1994; although, it seems that the virus has infected fruit-eating bats (flying-foxes) for a very long time. At least 2 humans and 15 horses have been killed by this virus since it first emerged as a virus that may infect mammals other than flying-foxes. Hendra virus is thought to have moved from flying-foxes to horses, and then from horses to people. There is a reasonably strong hypothesis for horse-to-human transmission: transmission of virus via nasal discharge, saliva and/or urine. In contrast, there is no strong hypothesis for flying-fox-to-human transmission. I present evidence that the Australian paralysis tick, Ixodes holocyclus, which has apparently only recently become a parasite of flying-foxes, may transmit Hendra virus and perhaps related viruses from flying-foxes to horses and other mammals.
Publication Date: 2003-03-05 PubMed ID: 12615503DOI: 10.1016/s0306-9877(02)00377-8Google Scholar: Lookup
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Summary

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This study proposes that the Australian paralysis tick could be responsible for transmitting the Hendra virus from fruit-eating bats to horses, then to humans.

Background of the Hendra Virus

  • Hendra virus is a novel virus from the Paramyxoviridae family, which was first discovered in Queensland, Australia, in 1994.
  • Though newly discovered, there’s evidence that fruit-eating bats (flying-foxes) have long been hosts of the virus.
  • Since its emergence, the virus has resulted in the death of at least 2 humans and 15 horses.

Transmission of Hendra Virus

  • The virus is thought to transmit from flying-foxes to horses before passing on to humans.
  • While the horse-to-human transmission hypothesis is well-supported — possibly through nasal discharge, saliva or urine — the means through which the virus is transmitted from flying-foxes to humans hasn’t been as clear.

Australian Paralysis Tick

  • The Australian paralysis tick (Ixodes holocyclus) could provide the missing link regarding the transmission of the Hendra virus from flying-foxes to other mammals, including horses.
  • The tick, which has seemingly only recently become a parasite of flying-foxes, is presented as a potential host and vector for the Hendra virus.

In conclusion, the research presents compelling evidence that the Australian paralysis tick may play a critical role in the transmission of the Hendra virus from flying-foxes to horses and subsequently to humans. However, further studies might be required to solidify this proposition and determine how this transmission can be effectively prevented or controlled.

Cite This Article

APA
Barker SC. (2003). The Australian paralysis tick may be the missing link in the transmission of Hendra virus from bats to horses to humans. Med Hypotheses, 60(4), 481-483. https://doi.org/10.1016/s0306-9877(02)00377-8

Publication

ISSN: 0306-9877
NlmUniqueID: 7505668
Country: United States
Language: English
Volume: 60
Issue: 4
Pages: 481-483

Researcher Affiliations

Barker, S C
  • Department of Microbiology and Parisitology, Institute for Molecular Biosciences, ARC Special Research Center for Functional and Applied Genomics, The University of Queensland, Brisbane, Australia. s.barker@imb.uq.edu.au

MeSH Terms

  • Animals
  • Chiroptera
  • Disease Transmission, Infectious
  • Ecology
  • Hendra Virus / pathogenicity
  • Horses
  • Humans
  • Models, Theoretical
  • Polymerase Chain Reaction
  • Ticks / virology

Citations

This article has been cited 3 times.
  1. Beard D, Stannard HJ, Old JM. Parasites of wombats (family Vombatidae), with a focus on ticks and tick-borne pathogens. Parasitol Res 2021 Feb;120(2):395-409.
    doi: 10.1007/s00436-020-07036-0pubmed: 33409643google scholar: lookup
  2. Gauci PJ, McAllister J, Mitchell IR, Cybinski D, St George T, Gubala AJ. Genomic Characterisation of Vinegar Hill Virus, An Australian Nairovirus Isolated in 1983 from Argas Robertsi Ticks Collected from Cattle Egrets. Viruses 2017 Dec 5;9(12).
    doi: 10.3390/v9120373pubmed: 29206186google scholar: lookup
  3. Burnouf T, Griffiths E, Padilla A, Seddik S, Stephano MA, Gutiérrez JM. Assessment of the viral safety of antivenoms fractionated from equine plasma. Biologicals 2004 Sep;32(3):115-28.