The cardiopulmonary effects of clenbuterol when administered to dorsally recumbent halothane-anaesthetised ponies–failure to increase arterial oxygenation.
Abstract: Clenbuterol (0.8 microg kg(-1) intravenously) was investigated in ponies (small horses) anaesthetised with acepromazine, detomidine and thiopentone, then halothane in oxygen alone (hyperoxic group) or with nitrous oxide (hypoxic group). Following instrumentation, ponies were placed in dorsal recumbency for 60 minutes, clenbuterol (both groups) or a saline control (hyperoxic group) given, and cardiopulmonary parameters monitored for a further 60 minutes. In the hyperoxic group, clenbuterol administration resulted in a transitory (<five minutes) 15 per cent fall in arterial blood pressure and 78 per cent rise in intramuscular blood flow. Heart rate increased from a mean of 42 (SD 4) to 54 (12) beats per minute, the rise being significant for 15 minutes. Cardiac index increased from 2.1 (0.7) to 3.9 (0.7) litres m(-2) and remained significantly elevated for the remainder of the measurement period. Cardiovascular changes in the hypoxic group were similar. 30 minutes after clenbuterol administration, PaO2 had changed nonsignificantly from 32.3 (19.2) to 33.4 (17) kPa in the hyperoxic group and from 7.9 (1.8) to 8.6 (1.3) kPa in the hypoxic group. The study concludes that under these experimental conditions, clenbuterol does not cause significant improvement in arterial oxygenation, but its cardiovascular effects are minimal or advantageous.
Publication Date: 1999-01-23 PubMed ID: 9915148DOI: 10.1016/s0034-5288(98)90148-5Google Scholar: Lookup
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- Clinical Trial
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research examines the effects of Clenbuterol, a drug used in treatment of breathing disorders on the heart and lungs of small horses (ponies), under anaesthetics. The findings indicate that despite resulting in minor cardiovascular changes, clenbuterol does not significantly improve arterial oxygenation.
Overview of the Study
- The aim of the study was to investigate the cardiopulmonary effects of Clenbuterol. This was done on anaesthetised ponies, specifically looking at the impact on arterial oxygenation – the level of oxygen in the blood.
- The ponies were anaesthetised using a combination of acepromazine, detomidine and thiopentone, and then maintained on halothane, a type of anaesthesia, either alone (hyperoxic group) or with nitrous oxide (hypoxic group).
- After a preparation period, the ponies were positioned on their backs (dorsal recumbency) for 60 minutes, during which time they were given either clenbuterol (both groups) or a saline control (hyperoxic group).
Observations from the Study
- Cardiopulmonary parameters were monitored for 60 minutes after administration of clenbuterol or saline control. The results showed certain cardiovascular changes both in the hyperoxic and hypoxic groups.
- In the hyperoxic group, giving clenbuterol led to a temporary decrease in arterial blood pressure and an increase in intramuscular blood flow. There was an increase in heart rate and cardiac index too. Similar changes were also noticed in the hypoxic group.
- However, the critical observation was there were no significant changes in arterial oxygenation 30 minutes after the clenbuterol administration, in both hyperoxic and hypoxic groups.
Conclusions of the Study
- Despite causing minor but transitory changes in cardiovascular parameters, the study found that clenbuterol does not significantly increase the level of oxygen in the blood (arterial oxygenation).
- The research hence concluded that while clenbuterol’s effects on heart and blood flow parameters were either minimal or advantageous, it does not improve arterial oxygenation significantly under the studied conditions.
Cite This Article
APA
Lee YH, Clarke KW, Alibhai HI.
(1999).
The cardiopulmonary effects of clenbuterol when administered to dorsally recumbent halothane-anaesthetised ponies–failure to increase arterial oxygenation.
Res Vet Sci, 65(3), 227-232.
https://doi.org/10.1016/s0034-5288(98)90148-5 Publication
Researcher Affiliations
- Department of Farm Animal and Equine Medicine and Surgery, Royal Veterinary College, Hatfield, Hertford.
MeSH Terms
- Anesthetics, Inhalation
- Animals
- Arteries
- Blood Gas Analysis
- Blood Pressure / drug effects
- Cardiac Output / drug effects
- Clenbuterol / administration & dosage
- Clenbuterol / pharmacology
- Drug Interactions
- Halothane
- Heart Rate / drug effects
- Horses / blood
- Horses / physiology
- Muscles / blood supply
- Oxygen / blood
- Oxygen Consumption / drug effects
- Posture
- Regional Blood Flow / drug effects
- Respiration / drug effects
- Stroke Volume / drug effects
- Sympathomimetics / administration & dosage
- Sympathomimetics / pharmacology
Citations
This article has been cited 2 times.- Tucker L, Almeida D, Wendt-Hornickle E, Baldo CF, Allweiler S, Guedes AGP. Effect of 15° Reverse Trendelenburg Position on Arterial Oxygen Tension during Isoflurane Anesthesia in Horses. Animals (Basel) 2022 Feb 1;12(3).
- Casoni D, Spadavecchia C, Adami C. Cardiovascular changes after administration of aerosolized salbutamol in horses: five cases. Acta Vet Scand 2014 Aug 14;56(1):49.
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