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Home / Equine Research Bank / Vet Surg / The effect of compacted cancellous bone grafting on the heal...
Veterinary surgery : VS2000; 29(1); 8-16; doi: 10.1111/j.1532-950x.2000.00008.x

The effect of compacted cancellous bone grafting on the healing of subchondral bone defects of the medial femoral condyle in horses.

Abstract: To compare the quality of second-intention healing and that of compacting sternally harvested cancellous bone into subchondral bone defects of the medial femoral condyle in horses. Methods: A controlled experiment using a surgical technique that minimizes soft tissue trauma, customized for consistency among horses. Methods: Ten horses, aged 2 to 5 years, free of hindlimb lameness and with radiographically normal stifles. Methods: After a 12.7-mm-diameter x 19-mm-deep defect was created into randomly selected medial femoral condyles, bone and cartilage healing was evaluated over a 6-month period in control horses (n = 5) and horses receiving a compacted cancellous bone graft (n = 5). Healing was evaluated using lameness assessment, radiographic and microradiographic interpretation, arthroscopic appearance, percent bone fill, proteoglycan content, and histology. Results: Six months after surgery, there was no significant difference between grafted and ungrafted defects with respect to lameness, radiographic score, or percent bone fill. Histologically, grafted defects were characterized by the presence of dead graft and secondary cyst formation in four defects. Ungrafted defects filled with fibrous tissue and no cyst formation were identified. Conclusions: Grafted defects do not heal better than ungrafted defects, and lameness was not affected by surgical technique. Conclusions: Cartilage healing is similar in grafted and ungrafted defects in the equine medial femoral condyle at 6 months, suggesting that surgical debridement alone of cystic structures remains the treatment of choice.
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Publication Date: 2000-02-01 PubMed ID: 10653490DOI: 10.1111/j.1532-950x.2000.00008.xGoogle Scholar: Lookup
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  • Clinical Trial
  • Controlled Clinical Trial
  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research experimented on the healing of subchondral bone defects in horses. The study compared the healing speed and quality between control horses and horses that received a compacted cancellous bone graft. Results after six months showed no significant difference in healing rate or bone fill, but grafted defects had more complications, including dead graft and secondary cyst formation.

Research Methodology

  • The study used a controlled experiment involving a customized surgical technique that minimizes soft tissue trauma, aiming for consistency among the test subjects.
  • There were ten horses included in the study, aged between 2 to 5 years, free of hindlimb lameness, and with radiographically normal stifles.
  • The researchers created a 12.7mm-diameter x 19mm-deep defect into randomly chosen medial femoral condyles. They then compared the healing between control horses (n=5) and horses that received a compacted cancellous bone graft (n=5) over six months.
  • Evaluation methods for healing included lameness assessment, radiographic and microradiographic interpretation, arthroscopic appearance, percent bone fill, proteoglycan content, and histology.

Results of Study

  • Based on the results, there was no significant difference observed between the grafted and ungrafted defects in terms of lameness, radiographic score, or percent bone fill after six months.
  • However, grafted defects showed the presence of dead graft and secondary cyst formation in four defects. Meanwhile, the ungrafted defects healed and were filled with fibrous tissue without any identified cyst formation.

Conclusions

  • The findings suggest that grafted defects don’t offer better healing than ungrafted defects, and that the surgical technique doesn’t have an impact on lameness.
  • The research also found that cartilage healing in grafted and ungrafted defects was similar for the equine medial femoral condyle at the six-month mark.
  • Considering the results, the study suggests that surgical debridement alone remains the preferred treatment of choice for cystic structures.

Cite This Article

APA
Jackson WA, Stick JA, Arnoczky SP, Nickels FA. (2000). The effect of compacted cancellous bone grafting on the healing of subchondral bone defects of the medial femoral condyle in horses. Vet Surg, 29(1), 8-16. https://doi.org/10.1111/j.1532-950x.2000.00008.x

Publication

Veterinary surgery : VS
ISSN: 0161-3499
NlmUniqueID: 8113214
Country: United States
Language: English
Volume: 29
Issue: 1
Pages: 8-16

Researcher Affiliations

Jackson, W A
  • Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824-1314, USA.
Stick, J A
    Arnoczky, S P
      Nickels, F A

        MeSH Terms

        • Animals
        • Arthroscopy / veterinary
        • Bone Cysts / physiopathology
        • Bone Cysts / surgery
        • Bone Cysts / veterinary
        • Bone Transplantation / veterinary
        • Femur / physiology
        • Femur / surgery
        • Horse Diseases / diagnostic imaging
        • Horse Diseases / physiopathology
        • Horse Diseases / surgery
        • Horses
        • Joint Diseases / physiopathology
        • Joint Diseases / surgery
        • Joint Diseases / veterinary
        • Lameness, Animal
        • Radiography
        • Random Allocation
        • Stifle / physiology
        • Stifle / surgery
        • Treatment Outcome
        • Wound Healing

        Citations

        This article has been cited 6 times.
        1. Murata D, Ishikawa S, Sunaga T, Saito Y, Sogawa T, Nakayama K, Hobo S, Hatazoe T. Osteochondral regeneration of the femoral medial condyle by using a scaffold-free 3D construct of synovial membrane-derived mesenchymal stem cells in horses. BMC Vet Res 2022 Jan 22;18(1):53.
          doi: 10.1186/s12917-021-03126-ypubmed: 35065631google scholar: lookup
        2. Kol'vek F, Krešáková L, Vdoviaková K, Medvecký Ľ, Žert Z. Modified Proximal Interphalangeal Joint Arthrodesis in a Yearling Filly with an Osseous Cyst-Like Lesion in the Proximal Phalanx. Animals (Basel) 2021 Mar 28;11(4).
          doi: 10.3390/ani11040948pubmed: 33800624google scholar: lookup
        3. Ribitsch I, Oreff GL, Jenner F. Regenerative Medicine for Equine Musculoskeletal Diseases. Animals (Basel) 2021 Jan 19;11(1).
          doi: 10.3390/ani11010234pubmed: 33477808google scholar: lookup
        4. Pál Z, Tuska P, Vásárhelyi G, Hangody L, Hurtig M, Kaposi AD, Bodó G. Mosaic arthroplasty in equine stifle and fetlock joints: A retrospective study of 31 cases between 1998 and 2023. Vet Surg 2025 Aug;54(6):1196-1207.
          doi: 10.1111/vsu.14296pubmed: 40576056google scholar: lookup
        5. Pérez-Nogués M, Manso-Díaz G, Spirito M, López-Sanromán J. Treatment Comparison for Medial Femoral Condyle Subchondral Cystic Lesions and Prognosis in Yearling Thoroughbred Racehorse Prospects. Animals (Basel) 2024 Apr 6;14(7).
          doi: 10.3390/ani14071122pubmed: 38612360google scholar: lookup
        6. Pérez-Nogués M, López-Sanromán J, Spirito M, Manso-Díaz G. Treatments and Prognosis for Subchondral Cystic Lesions in the Distal Extremities in Thoroughbred Prospect Racehorses. Animals (Basel) 2023 Sep 7;13(18).
          doi: 10.3390/ani13182838pubmed: 37760238google scholar: lookup
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