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Home / Equine Research Bank / Acta Vet Scand / The effect of detomidine hydrochloride on the electrical act...
Acta veterinaria Scandinavica1989; 30(3); 307-311; doi: 10.1186/BF03548036

The effect of detomidine hydrochloride on the electrical activity of uterus in pregnant mares.

Abstract: The effect of detomidine on the electrical activity of the uterus was studied during the last trimester of pregnancy in 6 mares. The effect was observed in 3-5 min after the i.m. injection and it lasted for 50-70 min. 20 and 40 micrograms/kg b.w. doses of detomidine decreased the myometrial electrical activity, whereas 60 micrograms/kg dose did not have any effect on the activity. The results suggested that 20, 40 and 60 micrograms/kg b.w. doses of detomidine can be administered to mares during the last trimester of pregnancy without the risk of abortion induced by increased uterine electrical activity. Effekten av detomidin på den elektriska aktiviteten i livmodern undersöktes under den sista trimestern hos 6 dräktiga ston. Effekten observerades 3–5 min efter i.m, injektion, och den kvarstod i 50–70 min. Doser av 20 och 40 μg/kg kroppsvikt minskade den elektriska aktiviteten i myometriet, medan en dos av 60 μg/kg inte hade någon effekt på aktiviteten. På basen av dessa resultat kan man utgå ifrån att doser av 20, 40 och 60 μg/kg detomidin /kg kroppsvikt kan ges åt ston under den sista dräktig-hetstrimestem utan risk för abort inducerad av en ökad elektrisk aktivitet i livmodern.
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Publication Date: 1989-01-01 PubMed ID: 2629506PubMed Central: PMC8142214DOI: 10.1186/BF03548036Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research studied how detomidine hydrochloride affects the electrical activity of a pregnant mare’s uterus within the last trimester, concluding that specific doses of detomidine could be administered to mares without risking abortion due to increased uterine electrical activity.

Study Objective and Methodology

  • This study targeted the impacts of detomidine hydrochloride on the electrical activity of uteruses in pregnant mares. In other words, it aimed to understand the physiological effects of this drug, specifically in the context of the final trimester of equine pregnancies.
  • The research involved the administration of detomidine to six mares in their last pregnancy trimester. Shot intramuscularly (i.m), the effects were then observed within a 3-5 minute span post-injection.
  • The injection was not singular: it was given in different doses—20, 40, and 60 micrograms/kg body weight (b.w)—to assess how varying quantities affected the uterine electrical activity.

Findings

  • After administering detomidine, the observable effects manifested themselves within just 3-5 minutes.
  • These results would last between 50-70 minutes post-injection.
  • Not all doses had the same effects: at 20 and 40 micrograms/kg b.w, detomidine was seen to decrease myometrial (muscular uterine wall) electrical activity. However, the 60 micrograms/kg b.w dose didn’t show any noticeable effects on the activity.

Conclusion

  • Findings provided a new understanding of how detomidine affects pregnant mares, particularly beneficial in contexts where the drug needs to be administered.
  • Based on results, 20, 40, and 60 micrograms/kg body weight doses of detomidine could be safely given to mares in their final pregnancy stage without any concerns for triggering an abortion due to increased electrical activity in the uterus.

Cite This Article

APA
Jedruch J, Gajewski Z, Kuussaari J. (1989). The effect of detomidine hydrochloride on the electrical activity of uterus in pregnant mares. Acta Vet Scand, 30(3), 307-311. https://doi.org/10.1186/BF03548036

Publication

Acta veterinaria Scandinavica
ISSN: 0044-605X
NlmUniqueID: 0370400
Country: England
Language: English
Volume: 30
Issue: 3
Pages: 307-311

Researcher Affiliations

Jedruch, J
    Gajewski, Z
      Kuussaari, J

        MeSH Terms

        • Analgesics / pharmacology
        • Animals
        • Electromyography / veterinary
        • Female
        • Horses / physiology
        • Hypnotics and Sedatives / pharmacology
        • Imidazoles / pharmacology
        • Pregnancy
        • Pregnancy, Animal / drug effects
        • Uterus / drug effects
        • Uterus / physiology

        References

        This article includes 14 references
        1. Alitalo I. Clinical experiences with Domosedan in horses and cattle. A review.. Acta Vet Scand Suppl 1986;82:193-6.
          pubmed: 3532727
        2. Csapo AJ. Progesteroneits regulatory effect on the myometrium. Ciba Foundation Study Group 1969;34:4.
        3. Figueroa JP, Mahan S, Poore ER, Nathanielsz PW. Characteristics and analysis of uterine electromyographic activity in the pregnant sheep.. Am J Obstet Gynecol 1985 Feb 15;151(4):524-31.
          doi: 10.1016/0002-9378(85)90282-0pubmed: 3976752google scholar: lookup
        4. Hanzen C. Uterine motility in cattle prior and post parturition. Current topics in Veterinary Medicine and Animal Science 1982;20:61–66.
        5. Harding R, Poore ER, Bailey A, Thorburn GD, Jansen CA, Nathanielsz PW. Electromyographic activity of the nonpregnant and pregnant sheep uterus.. Am J Obstet Gynecol 1982 Feb 15;142(4):448-57.
          doi: 10.1016/S0002-9378(16)32389-4pubmed: 7199257google scholar: lookup
        6. Jedruch J, Gajewski Z. The effect of detomidine hydrochloride (Domosedan) on the electrical activity of the uterus in cows.. Acta Vet Scand Suppl 1986;82:189-92.
          pubmed: 3464179
        7. Jöchle W, Hamm D. Sedation and analgesia with Domosedan (detomidine hydrochloride) in horses: dose response studies on efficacy and its duration.. Acta Vet Scand Suppl 1986;82:69-84.
          pubmed: 3464184
        8. Leblanc MM, Hubbell JA, Smith HC. The effects of xylazine hydrochloride on intrauterine pressure in the cow.. Theriogenology 1984 May;21(5):681-90.
          doi: 10.1016/0093-691X(84)90014-1pubmed: 16725917google scholar: lookup
        9. Prud'homme MJ. Uterine motor responses to an alpha-adrenergic agonist (phenylephrine) in the ewe during oestrus and at the end of gestation.. Reprod Nutr Dev (1980) 1986;26(3):827-39.
          doi: 10.1051/rnd:19860507pubmed: 3749600google scholar: lookup
        10. Salonen JS. Pharmacokinetics of detomidine.. Acta Vet Scand Suppl 1986;82:59-66.
          pubmed: 3464183
        11. Savola JM. Cardiovascular actions of detomidine.. Acta Vet Scand Suppl 1986;82:47-57.
          pubmed: 3464182
        12. Szeligowski E, Janicki AM, Krzeski M. Detomidine (Domosedan) in sedation, premedication and general anaesthesia of horses.. Acta Vet Scand Suppl 1986;82:181-5.
          pubmed: 3464178
        13. Taverne MA, van der Weyden GC, Fontijne P, Dieleman SJ, Pashen RL, Allen WR. In-vivo myometrial electrical activity in the cyclic mare.. J Reprod Fertil 1979 Jul;56(2):521-32.
          doi: 10.1530/jrf.0.0560521pubmed: 573325google scholar: lookup
        14. Virtanen R. Pharmacology of detomidine and other alpha 2-adrenoceptor agonists in the brain.. Acta Vet Scand Suppl 1986;82:35-46.
          pubmed: 2876607

        Citations

        This article has been cited 0 times.
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