The effect of intramuscular atipamezole on head height and sedation scores in detomidine-sedated horses.
Abstract: To assess the effect of two different doses of intramuscular atipamezole on head height (HH) in horses after sedation with detomidine. Methods: Randomized, blinded, triple crossover study. Methods: Eight healthy adult horses. Methods: Baseline HH was measured before detomidine (40 μg kg) was injected intravenously. HH was measured at 10 and 20 minutes after injection. Then, saline, atipamezole 60 μg kg (AT60) or 120 μg kg (AT120) was injected intramuscularly. HH measurements were repeated at 10 minutes intervals for 100 minutes. HH data were analyzed with a linear mixed model. Significance was set at p 0.05). AT60 HH was greater than saline at 80 (33 ± 11 versus 28 ± 11), 90 (45 ± 15 versus 26 ± 13), and 110 (57 ± 24 versus 32 ± 11) minutes (all p < 0.002). AT120 HH was greater than saline at 50 (33 ± 16 versus 22 ± 8), 80 (44 ± 11 versus 28 ± 11), 90 (45 ± 11 versus 26 ± 13), 100 (52 ± 18 versus 30 ± 16) and 110 (64 ± 23 versus 32 ± 11) minutes (all p 0.05). Conclusions: Horses administered atipamezole showed signs of reversal of sedation, as evaluated by HH compared with saline. Horses administered the higher dose of atipamezole had HH greater than saline sooner than horses administered the lower dose. Intramuscular atipamezole may be useful for reversal of detomidine sedation in horses.
Copyright © 2024 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Published by Elsevier Ltd. All rights reserved.
Publication Date: 2024-11-26 PubMed ID: 39672697DOI: 10.1016/j.vaa.2024.11.008Google Scholar: Lookup
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- Journal Article
Summary
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The research investigates how using two different doses of intramuscular atipamezole affects the wakefulness (as measured by head height) of horses that have been sedated with detomidine.
Research Methodology
- The researchers designed a randomized, blinded, triple crossover study involving eight healthy adult horses.
- The head height of these horses was measured before an intravenous injection of detomidine was administered.
- After 10 and 20 minutes post detomidine injection, head height was measured again.
- Subsequent to this, intramuscular injections of either saline, 60 µg/kg of atipamezole (AT60), or 120 µg/kg of atipamezole (AT120) were administered to the horses.
- Head height was then measured at 10-minute intervals for 100 minutes after the atipamezole administration.
- The head height data collected was statistically analyzed using a linear mixed model and the significance was set at a p-value of less than 0.05.
Results and Observations
- No significant variations were observed among the baseline head heights from different trial groups (saline, AT60, and AT120).
- Horses who had received AT60 had greater head height than those given saline at the 80, 90, and 110-minute marks. These differences were statistically significant.
- Horses administered AT120 exhibited increased head height when compared to saline at the 50, 80, 90, 100, and 110-minute marks. These findings were also statistically significant.
- No significant differences were observed in the head height at any time point between the AT60 and AT120 groups.
Conclusions
- The results suggested that horses given atipamezole showed signs of sedation reversal, as evidenced by increased head height in comparison to those administered saline.
- Horses that received a higher dosage of atipamezole had increased head height sooner than horses given the lower dosage.
- Therefore, the study concluded that intramuscular atipamezole could be potentially useful in reversing the effects of detomidine-induced sedation in horses.
Cite This Article
APA
Mascarenhas C, Castro D, Lascola KM, Hofmeister E, Clark-Price SC.
(2024).
The effect of intramuscular atipamezole on head height and sedation scores in detomidine-sedated horses.
Vet Anaesth Analg, S1467-2987(24)00345-3.
https://doi.org/10.1016/j.vaa.2024.11.008 Publication
Researcher Affiliations
- Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, USA.
- Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, USA. Electronic address: dzc0087@auburn.edu.
- Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, USA.
- Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, USA.
- Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, USA.
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