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The effect of short- and long-term treatment with manuka honey on second intention healing of contaminated and noncontaminated wounds on the distal aspect of the forelimbs in horses.
Abstract: To compare the effects of manuka honey and manuka honey gel on second intention healing of noncontaminated distal limb wounds and those contaminated with feces. Methods: Experimental study. Methods: Standardbred horses (n = 10). Methods: Five full-thickness wounds (2 × 2 cm) were created on both metacarpi. Wounds on 1 forelimb were covered with horse feces for 24 hours. Wounds on the contralateral limb were left uncontaminated. Wounds were assigned to the following 5 different treatments: manuka honey, manuka honey gel or gel applied for 12 days, manuka honey gel applied throughout healing and untreated control. Wound area was measured on day 1 then weekly until day 42 and time to complete healing was recorded. Results: Wounds treated with manuka honey gel throughout healing healed faster than all other wounds (P < .05). Wounds treated with manuka honey and manuka honey gel for 12 days healed faster than gel control and untreated control wounds (P < .05). Wounds treated with manuka honey and manuka honey gel for 12 days and throughout healing were smaller than gel control and untreated control wounds until day 35 (P < .05). Wounds contaminated with feces had greater retraction for 7 days, but healed faster than noncontaminated wounds (P < .05). Conclusions: Treatment of wounds with manuka honey and manuka honey gel reduced wound retraction and overall healing time compared with gel and untreated control wounds.
© Copyright 2012 by The American College of Veterinary Surgeons.
Publication Date: 2012-12-05 PubMed ID: 23216146DOI: 10.1111/j.1532-950X.2012.01083.xGoogle Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
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The research article looks into the impacts of manuka honey and manuka honey gel on wound healing in horses. The wounds investigated in the study are both non-contaminated and feces-contaminated. Results show both variations of honey quickened the healing process compared to untreated or traditionally treated wounds.
Objective and Methodology
- The study sought to compare the effects of issue recovery in horse wounds when treated with manuka honey and manuka honey gel. The types of wounds included were non-contaminated distal limb wounds and others that had been contaminated with feces.
- An experimental format was employed for the study, featuring a total of 10 Standardbred horses. Five full-thickness wounds measuring two-by-two centimeters each were created on both metacarpi. One forelimb’s wounds were smeared with horse feces for a day, while the other forelimb was kept clean.
- These wounds were subject to five different kinds of treatment, namely manuka honey, manuka honey gel or gel applied for 12 days, manuka honey gel applied continuously while healing, or just left untreated.
Findings
- The healing progress of the wounds was tracked by measuring wound area on the inaugural day and then once every week until day 42 when healing was again recorded.
- The wounds that were treated with manuka honey based gel throughout the healing phase healed quicker than all the other types of wounds.
- Wounds treated with either manuka honey or the honey gel for 12 days resulted in quicker healing than wounds that had a traditional gel applied or were left untreated.
- Up until day 35, wounds treated with the honey or honey gel for 12 days were smaller than those treated with conventional gel or left untreated.
- Despite initially showing greater retraction, the wounds that were contaminated with feces ended up healing faster than clean wounds.
Conclusion
- The results concluded that using manuka honey and manuka honey gel to treat wounds minimized wound retraction and accelerated the total healing process when compared to wounds treated with gel or left untreated.
Cite This Article
APA
Bischofberger AS, Dart CM, Perkins NR, Kelly A, Jeffcott L, Dart AJ.
(2012).
The effect of short- and long-term treatment with manuka honey on second intention healing of contaminated and noncontaminated wounds on the distal aspect of the forelimbs in horses.
Vet Surg, 42(2), 154-160.
https://doi.org/10.1111/j.1532-950X.2012.01083.x Publication
Researcher Affiliations
- Biomedical Research and Clinical Trials Unit, University Veterinary Teaching Hospital Camden, University of Sydney, Camden, Australia.
MeSH Terms
- Animals
- Gels
- Honey
- Horses / injuries
- Leptospermum
- Male
- Metacarpus
- Skin / injuries
- Wound Healing / drug effects
- Wound Healing / physiology
- Wound Infection / physiopathology
- Wound Infection / prevention & control
- Wound Infection / veterinary
Citations
This article has been cited 14 times.- Niyangoda D, Muayad M, Tesfaye W, Bushell M, Ahmad D, Samarawickrema I, Sinclair J, Kebriti S, Maida V, Thomas J. Cannabinoids in Integumentary Wound Care: A Systematic Review of Emerging Preclinical and Clinical Evidence. Pharmaceutics 2024 Aug 17;16(8).
- Ribeiro G, Carvalho L, Borges J, Prazeres J. The Best Protocol to Treat Equine Skin Wounds by Second Intention Healing: A Scoping Review of the Literature. Animals (Basel) 2024 May 18;14(10).
- Gouletsou PG, Zacharopoulou T, Skampardonis V, Georgiou SG, Doukas D, Galatos AD, Flouraki E, Dermisiadou E, Margeti C, Barbagianni M, Sideri A, Tsioli V. First-Intention Incisional Wound Healing in Dogs and Cats: A Controlled Trial of Dermapliq and Manuka Honey. Vet Sci 2024 Feb 1;11(2).
- Chatzimisios K, Tsioli V, Brellou GD, Apostolopoulou EP, Angelou V, Pratsinakis ED, Cremers NAJ, Papazoglou LG. Evaluation of the Effectiveness of Medical-Grade Honey and Hypericum Perforatum Ointment on Second-Intention Healing of Full-Thickness Skin Wounds in Cats. Animals (Basel) 2023 Dec 21;14(1).
- Muñoz M, Del Sol M, Vásquez B. Antibacterial and wound-healing action of Ulmo honey (Eucryphia cordifolia) of differing degrees of purity. Front Vet Sci 2023;10:1172025.
- Terschuur JA, Coomer RPC, McKane SA. Administration safety of medical-grade honey (MGH) in septic synovial structures in horses: 3 cases. Can J Vet Res 2023 Apr;87(2):153-156.
- Thierig M, Raupbach J, Wolf D, Mascher T, Subramanian K, Henle T. 3-Phenyllactic Acid and Polyphenols Are Substances Enhancing the Antibacterial Effect of Methylglyoxal in Manuka Honey. Foods 2023 Mar 4;12(5).
- Kulyar MF, Ashfaq K, Aqib AI, Duan K, Asif M, Bhutta ZA, Shoaib M, Shabbir S, Nawaz S, Naseer MA, Sarwar I, Akhtar M, Chaudhry AS, Hussain R, Hussain HI, Wu Y, Li K. Enhanced Healing Activity of Manuka Honey and Nitrofurazone Composite in Full-Thickness Burn Wounds in the Rabbit Model. Front Vet Sci 2022;9:875629.
- Jørgensen E, Bjarnsholt T, Jacobsen S. Biofilm and Equine Limb Wounds. Animals (Basel) 2021 Sep 27;11(10).
- Brown HL, Metters G, Hitchings MD, Wilkinson TS, Sousa L, Cooper J, Dance H, Atterbury RJ, Jenkins R. Antibacterial and Antivirulence Activity of Manuka Honey against Genetically Diverse Staphylococcus pseudintermedius Strains. Appl Environ Microbiol 2020 Oct 1;86(20).
- McLoone P, Oluwadun A, Warnock M, Fyfe L. Honey: A Therapeutic Agent for Disorders of the Skin. Cent Asian J Glob Health 2016;5(1):241.
- Olofsson TC, Butler É, Lindholm C, Nilson B, Michanek P, Vásquez A. Fighting Off Wound Pathogens in Horses with Honeybee Lactic Acid Bacteria. Curr Microbiol 2016 Oct;73(4):463-73.
- Ferrari R, Boracchi P, Romussi S, Ravasio G, Stefanello D. Application of hyaluronic acid in the healing of non-experimental open wounds: A pilot study on 12 wounds in 10 client-owned dogs. Vet World 2015 Oct;8(10):1247-59.
- Francis A, Cho Y, Johnson DW. Honey in the Prevention and Treatment of Infection in the CKD Population: A Narrative Review. Evid Based Complement Alternat Med 2015;2015:261425.
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