The effects of a nutritional supplement containing salacinol in neonatal Thoroughbred foals.
Abstract: A nutritional supplement containing salacinol (NSS) was administered to Thoroughbred foals daily beginning 21 days after birth, and clinical signs and intestinal microbiota were analyzed. The average number of days for which foals exhibited a fever between 21 and 110 days after birth was determined. The number of days was significantly reduced, by approximately 1/3, in the NSS group compared with the control group. Furthermore, improved weight gain was observed in the NSS group compared with the control group. By analyzing the intestinal microbiota, it was determined that the ratio of Clostridium cluster XIVa increased after 3 weeks of NSS administration. These results demonstrate that the daily administration of NSS might improve the intestinal environment of neonatal foals and be useful for health.
©2020 The Japanese Society of Equine Science.
Publication Date: 2020-03-19 PubMed ID: 32206034PubMed Central: PMC7078488DOI: 10.1294/jes.31.11Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This study assesses the impact of a nutritional supplement containing salacinol (NSS) on newborn Thoroughbred foals, finding that it led to reduced incidents of fever, better weight gain, and improved gut health.
Research Introduction
The research article explores the effects of a nutritional supplement containing salacinol (NSS) on neonatal or newborn Thoroughbred foals. The aim was to determine any physiological changes and benefits arising from the administration of NSS, with a specific focus on possible improvements in overall health and intestinal hygiene.
Methodology
Researchers conducted their study by administering the NSS to the foals starting 21 days after their birth. Clinical signs of health or distress and changes in the foals’ intestinal microbiota were closely monitored and recorded as part of the study.
- The average number of days in which a foal exhibited fever from 21 to 110 days after birth was carefully logged.
- Weight gain was monitored to assess the physical development of the foals.
- Intestinal microbiota, particularly the ratio of Clostridium cluster XIVa, was analyzed to understand the impact on gut health. Clostridium cluster XIVa is known to affect the gastrointestinal environment significantly.
Results
Key findings from the study are as follows:
- The number of days a foal experienced fever was significantly reduced in the NSS group compared to the control group. The reduction was by about one-third, indicating that the NSS could be helping boost the foals’ immune system or overall health to resist fever.
- The weight gain was more pronounced in foals in the NSS group than in the control group. This could imply that the NSS facilitated better nutrient absorption or overall growth in the foals.
- Upon analyzing the intestinal microbiota, it was found that the ratio of Clostridium cluster XIVa increased after three weeks of NSS administration. This increase could suggest an improved intestinal environment for the foals.
Conclusion
The research concluded that the daily administration of the salacinol-containing nutritional supplement might enhance the neonatal foals’ intestinal health. In doing so, it could contribute to the overall health and wellness of the animals, as indicated by reduced fever duration and improved weight gain. Thus, NSS has potential use within animal management and veterinary interventions for newborn animals.
Cite This Article
APA
Iida A, Saito H, Amao A, Fujita T, Kato A, Ueda F.
(2020).
The effects of a nutritional supplement containing salacinol in neonatal Thoroughbred foals.
J Equine Sci, 31(1), 11-15.
https://doi.org/10.1294/jes.31.11 Publication
Researcher Affiliations
- Bio Science & Engineering Laboratory Research & Development Management Headquarters, FUJIFILM Corporation, Kanagawa 258-8577, Japan.
- Bio Science & Engineering Laboratory Research & Development Management Headquarters, FUJIFILM Corporation, Kanagawa 258-8577, Japan.
- Highly Functional Materials Business Development Headquarters, FUJIFILM Corporation, Tokyo 107-0052, Japan.
- Shadai Farm, Hokkaido 069-1181, Japan.
- Shadai Farm, Hokkaido 069-1181, Japan.
- Bio Science & Engineering Laboratory Research & Development Management Headquarters, FUJIFILM Corporation, Kanagawa 258-8577, Japan.
References
This article includes 21 references
- Argenzio RA, Hintz HF. Effect of diet on glucose entry and oxidation rates in ponies.. J Nutr 1972 Jul;102(7):879-92.
- Barcenilla A, Pryde SE, Martin JC, Duncan SH, Stewart CS, Henderson C, Flint HJ. Phylogenetic relationships of butyrate-producing bacteria from the human gut.. Appl Environ Microbiol 2000 Apr;66(4):1654-61.
- Bergman EN. Energy contributions of volatile fatty acids from the gastrointestinal tract in various species.. Physiol Rev 1990 Apr;70(2):567-90.
- Frederick J, Giguère S, Sanchez LC. Infectious agents detected in the feces of diarrheic foals: a retrospective study of 233 cases (2003-2008).. J Vet Intern Med 2009 Nov-Dec;23(6):1254-60.
- Furusawa Y, Obata Y, Fukuda S, Endo TA, Nakato G, Takahashi D, Nakanishi Y, Uetake C, Kato K, Kato T, Takahashi M, Fukuda NN, Murakami S, Miyauchi E, Hino S, Atarashi K, Onawa S, Fujimura Y, Lockett T, Clarke JM, Topping DL, Tomita M, Hori S, Ohara O, Morita T, Koseki H, Kikuchi J, Honda K, Hase K, Ohno H. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells.. Nature 2013 Dec 19;504(7480):446-50.
- Kajimoto O, Kawamori S, Shimoda H, Kawahara Y, Hirata H, Takahashi T. Effects of a diet containing Salacia reticulata on mild type 2 diabetes in humans. A placebo-controlled, cross-over trial.. J. Jpn. Soc. Nutr. Food Sci. 53: 199–205.
- Lindenberg F, Krych L, Fielden J, Kot W, Frøkiær H, van Galen G, Nielsen DS, Hansen AK. Expression of immune regulatory genes correlate with the abundance of specific Clostridiales and Verrucomicrobia species in the equine ileum and cecum.. Sci Rep 2019 Sep 3;9(1):12674.
- Mair TS, Taylor FG, Pinsent PJ. Fever of unknown origin in the horse: a review of 63 cases.. Equine Vet J 1989 Jul;21(4):260-5.
- Matsuura T, Yoshikawa Y, Masui H, Sano M. [Suppression of glucose absorption by various health teas in rats].. Yakugaku Zasshi 2004 Apr;124(4):217-23.
- Muraoka O, Morikawa T, Miyake S, Akaki J, Ninomiya K, Yoshikawa M. Quantitative determination of potent alpha-glucosidase inhibitors, salacinol and kotalanol, in Salacia species using liquid chromatography-mass spectrometry.. J Pharm Biomed Anal 2010 Sep 5;52(5):770-3.
- Muraoka O, Morikawa T, Miyake S, Akaki J, Ninomiya K, Pongpiriyadacha Y, Yoshikawa M. Quantitative analysis of neosalacinol and neokotalanol, another two potent α-glucosidase inhibitors from Salacia species, by LC-MS with ion pair chromatography.. J Nat Med 2011 Jan;65(1):142-8.
- Nagashima K, Mochizuki J, Hisada T, Suzuki S, Shimomura K. Phylogenetic analysis of 16S ribosomal RNA gene sequences from human fecal microbiota and improved utility of terminal restriction fragment length polymorphism profiling.. Biosci. Microflora 25: 99–107.
- Oda Y, Ueda F, Kamei A, Kakinuma C, Abe K. Biochemical investigation and gene expression analysis of the immunostimulatory functions of an edible Salacia extract in rat small intestine.. Biofactors 2011 Jan-Feb;37(1):31-9.
- Oda Y, Ueda F, Utsuyama M, Kamei A, Kakinuma C, Abe K, Hirokawa K. Improvement in Human Immune Function with Changes in Intestinal Microbiota by Salacia reticulata Extract Ingestion: A Randomized Placebo-Controlled Trial.. PLoS One 2015;10(12):e0142909.
- Premakumari S, Kowsalya S, Sailaavanya S, Mujumdar V. Sub-chronic toxicity of Ekanayakam (Salacia reticulata) in albino rats.. Indian J. Nutr. Diet. 46: 1–13.
- Radha R, Amrithaveni M. Role of medicinal plant Salacia Reticulata in the management of Type II Diabetic Subjects.. Anc Sci Life 2009 Jul;29(1):14-6.
- Roediger WE. Utilization of nutrients by isolated epithelial cells of the rat colon.. Gastroenterology 1982 Aug;83(2):424-9.
- Romero-Pérez GA, Egashira M, Harada Y, Tsuruta T, Oda Y, Ueda F, Tsukahara T, Tsukamoto Y, Inoue R. Orally Administered Salacia reticulata Extract Reduces H1N1 Influenza Clinical Symptoms in Murine Lung Tissues Putatively Due to Enhanced Natural Killer Cell Activity.. Front Immunol 2016;7:115.
- Tanabe S, Suzuki T, Wasano Y, Nakajima F, Kawasaki H, Tsuda T, Nagamine N, Tsurumachi T, Sugaya K, Akita H, Takagi M, Takagi K, Inoue Y, Asai Y, Morita H. Anti-inflammatory and Intestinal Barrier-protective Activities of Commensal Lactobacilli and Bifidobacteria in Thoroughbreds: Role of Probiotics in Diarrhea Prevention in Neonatal Thoroughbreds.. J Equine Sci 2014;25(2):37-43.
- Yoshikawa M, Morikawa T, Matsuda H, Tanabe G, Muraoka O. Absolute stereostructure of potent alpha-glucosidase inhibitor, Salacinol, with unique thiosugar sulfonium sulfate inner salt structure from Salacia reticulata.. Bioorg Med Chem 2002 May;10(5):1547-54.
- Yuyama T, Takai S, Tsubaki S, Kado Y, Morotomi M. Evaluation of a host-specific Lactobacillus probiotic in training-horses and neonatal foals.. J. Intestinal Microbio. 18: 101–106.
Citations
This article has been cited 0 times.Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
