The effects of cisapride on the restoration of gut motility after surgery of the small intestine in horses; a clinical trial.

This research paper describes a clinical trial conducted on seventy horses to investigate the impacts of the drug cisapride on recovery of gut motion after small intestine surgery. The researchers found that cisapride helped to speed up the recovery process, reducing the period of intensive care after surgery.

Research Methodology

• The research involved a trial on seventy horses that had undergone surgery for colic due to issues within the small intestine.
• The study was conducted in a randomized, blind manner, ensuring the researchers did not have prior knowledge of which horses were given the medication and which ones were not.
• The horses were given doses of cisapride at 0.1 mg/kg body weight at regular intervals of 8 hours.

Key Findings

• The study found that the administration of cisapride resulted in a reduced incidence of post-operative ileus, which is a delay in the restoration of bowel function following surgical operations.
• Additionally, it was observed that cisapride sped up the restoration of bowel motility.
• As a consequence, the time period of post-operative intensive care for the horses was minimized, which connotes a more expedient and efficient recovery process.

Conclusion

• The authors concluded that cisapride is an effective medication for assisting post-operative recovery in horses following surgery of the small intestine.
• The drug not only aids in the rapid restoration of gut motility but also decreases the duration of intensive care required post-surgery.
• This makes cisapride a valuable drug in the post-operative treatment protocol for horses that have undergone small intestine surgery.