The Effects of Intra-Articular Triamcinolone and Autologous Protein Solution on Metabolic Parameters in Horses.
Abstract: Intra-articular corticosteroids are a popular treatment choice for joint-associated pain and inflammation in horses despite recent work on the metabolic effects of these drugs. The goal of this project was to compare metabolic effects between intra-articular (IA) triamcinolone acetonide (TA) and an autologous protein solution (APS). Five mixed-breed geldings (4-9 years) were utilized for this project. Three identical and consecutive 28-day treatment blocks were used, with metacarpophalangeal IA treatments consisting of equal volumes of saline, a commercially available APS, or 9 mg of TA. Regular plasma and serum samples were collected for ACTH, cortisol, glucose, insulin, and thyroid hormone analysis, in addition to thyrotropin-releasing hormone (TRH) and oral sugar tests (OSTs). Significant treatment effects of IA TA were present at 48 h post-injection in both the TRH and the OST. There was also significant suppression by IA TA of baseline ACTH and cortisol between 2 h and 96 h post-treatment, hyperglycemia between 12 h and 48 h, and hyperinsulinemia at 32 h post-treatment. There were no treatment effects with respect to any measured thyroid hormones, nor were there any significant treatment effects of APS noted. Results suggest at least 2 days and up to 7 days should elapse between a single 9 mg IA TA treatment and OST and/or TRH testing. This study found that TA exhibits significant effects on ACTH, cortisol, glucose, and insulin, while the APS does not.
Publication Date: 2024-08-02 PubMed ID: 39123776PubMed Central: PMC11311071DOI: 10.3390/ani14152250Google Scholar: Lookup
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- Journal Article
Summary
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The study explores the metabolic effects of intra-articular corticosteroids, specifically Triamcinolone Acetonide (TA), compared to Autologous Protein Solution (APS) treatment on horses. The paper specifically highlights that while TA showed marked effects on ACTH, cortisol, glucose, and insulin, APS treatment did not.
Methodology
The study used five mixed-breed geldings aged between 4 and 9 years. Researchers organized three consecutive 28-day treatment blocks, in which each block saw the use of intra-articular treatments of saline, APS and an amount of 9mg TA. The treatments were injected into the metacarpophalangeal IA of the horses.
- Samples of serum and plasma were collected routinely for testing levels thyroid hormones, ACTH (adrenocorticotropic hormone), cortisol, glucose, and insulin.
- Thyrotropin-releasing hormone (TRH) and oral sugar tests (OSTs) were performed to monitor the metabolic effects of the treatments.
Results
- Potential treatment effects of TA were detected 48 hours post-injection with both OST and TRH tests.
- The study found TA had a suppressive effect on the baseline secretion of ACTH and cortisol. This effect was measured between 2 hours and 96 hours after the treatment was applied.
- Hyperglycemia (high blood sugar) was observed between 12 and 48 hours, and Hyperinsulinemia (excess levels of insulin) was observed to peak at 32 hours post-treatment.
- There were no treatment effects detected in terms of thyroid hormones.
- Regarding the APS treatment, there were no notable treatment effects observed.
Conclusions
- The study concluded that TA treatment has noteworthy effects on ACTH, cortisol, glucose, and insulin levels in horses.
- There were no observed significant effects from the APS treatment.
- The study suggests that between treatments of single 9 mg IA TA and OST and/or TRH testing, a period of at least 2 days and up to 7 days should elapse to properly monitor the effects.
Cite This Article
APA
Page AE, Johnson M, Parker JL, Jacob O, Poston R, Adams AA, Adam EN.
(2024).
The Effects of Intra-Articular Triamcinolone and Autologous Protein Solution on Metabolic Parameters in Horses.
Animals (Basel), 14(15), 2250.
https://doi.org/10.3390/ani14152250 Publication
Researcher Affiliations
- Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40546, USA.
- Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40546, USA.
- Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40546, USA.
- Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40546, USA.
- Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40546, USA.
- Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40546, USA.
- Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40546, USA.
Grant Funding
- N/A / Zoetis (United States)
Conflict of Interest Statement
This project was funded by Zoetis, LLC. While this manuscript was provided to the company prior to publication, the study design, data analysis, and interpretation of results are solely those of the authors.
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