Journal of the American Veterinary Medical Association2018; 253(4); 470-478; doi: 10.2460/javma.253.4.470

Case-control study of risk factors for pasture-and endocrinopathy-associated laminitis in North American horses.

Abstract: OBJECTIVE To investigate risk factors for the development of pasture- and endocrinopathy-associated laminitis (PEAL) in horses and ponies in North America. DESIGN Case-control study. ANIMALS 199 horses with incident cases of PEAL and 351 horses from 2 control populations (healthy horses [n = 198] and horses with lameness not caused by laminitis [153]) that were evaluated in North America between January 2012 and December 2015 by veterinarian members of the American Association of Equine Practitioners. PROCEDURES North American members of the American Association of Equine Practitioners were contacted to participate in the study, and participating veterinarians provided historical data on incident cases of PEAL, each matched with a healthy control and a lameness control. Conditional logistic regression analysis was used to compare data on PEAL-affected horses with data on horses from each set of controls. RESULTS Horses with an obese body condition (ie, body condition score ≥ 7), generalized or regional adiposity (alone or in combination), preexisting endocrinopathy, or recent (within 30 days) glucocorticoid administration had increased odds of developing PEAL, compared with horses that did not have these findings. CONCLUSIONS AND CLINICAL RELEVANCE The present study identified several risk factors for PEAL that may assist not only in managing and preventing this form of laminitis, but also in guiding future research into its pathogenesis.
Publication Date: 2018-07-31 PubMed ID: 30058970DOI: 10.2460/javma.253.4.470Google Scholar: Lookup
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  • Journal Article

Summary

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The research article is about an investigation into the risk factors that contribute to the development of pasture and endocrinopathy-associated laminitis in horses and ponies in North America.

Study Design and Participants

  • The research paper is based on a case-control study which aimed to investigate the risk factors leading to the development of pasture and endocrinopathy-associated laminitis (PEAL) in horses and ponies from North America.
  • A total of 199 horses having PEAL were included in the case population, while 198 healthy horses and 153 horses suffering from lameness not related to laminitis formed two separate control groups.
  • The cases and control groups were evaluated by veterinarian members of the American Association of Equine Practitioners from 2012 to 2015.

Study Procedure

  • The members of the American Association of Equine Practitioners from North America were requested to participate in the investigation.
  • The participating veterinarians provided historical data of new PEAL cases which were then matched with healthy controls and lameness controls.
  • Conditional logistic regression analysis was employed to compare the data from PEAL-affected horses with horses from the two control sets. This helped in identifying risk factors.

Results

  • The study discovered that horses displaying an obese body condition (body condition score equal to or greater than 7), generalized or regional adiposity (alone or combined), preexisting endocrinopathy, or recent (within 30 days) administration of glucocorticoids demonstrated higher odds of suffering from PEAL compared to horses without these symptoms.

Conclusions and Clinical Relevance

  • The identification of several risk factors for PEAL in the study might be useful in managing and preventing this type of laminitis.
  • Further, the results of this research could also encourage and guide future studies into understanding the pathogenesis of PEAL.

Cite This Article

APA
Coleman MC, Belknap JK, Eades SC, Galantino-Homer HL, Hunt RJ, Geor RJ, McCue ME, McIlwraith CW, Moore RM, Peroni JF, Townsend HG, White NA, Cummings KJ, Ivanek-Miojevic R, Cohen ND. (2018). Case-control study of risk factors for pasture-and endocrinopathy-associated laminitis in North American horses. J Am Vet Med Assoc, 253(4), 470-478. https://doi.org/10.2460/javma.253.4.470

Publication

ISSN: 1943-569X
NlmUniqueID: 7503067
Country: United States
Language: English
Volume: 253
Issue: 4
Pages: 470-478

Researcher Affiliations

Coleman, Michelle C
    Belknap, Jim K
      Eades, Susan C
        Galantino-Homer, Hannah L
          Hunt, Robert J
            Geor, Ray J
              McCue, Molly E
                McIlwraith, C Wayne
                  Moore, Rustin M
                    Peroni, John F
                      Townsend, Hugh G
                        White, Nathaniel A
                          Cummings, Kevin J
                            Ivanek-Miojevic, Renata
                              Cohen, Noah D

                                MeSH Terms

                                • Animal Husbandry
                                • Animals
                                • Canada / epidemiology
                                • Case-Control Studies
                                • Female
                                • Foot Diseases / epidemiology
                                • Foot Diseases / veterinary
                                • Hoof and Claw
                                • Horse Diseases / epidemiology
                                • Horse Diseases / etiology
                                • Horse Diseases / prevention & control
                                • Horses
                                • Incidence
                                • Inflammation / veterinary
                                • Lameness, Animal
                                • Male
                                • Risk Factors
                                • United States / epidemiology

                                Citations

                                This article has been cited 10 times.
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