Omneity® Pellets
All-In-One Vitamin & Mineral Pellet
The effects of pentoxifylline on equine platelet aggregation.
Abstract: Pentoxifylline (PTX) possesses a number of vasomotor, immunomodulatory, and hemorheologic properties. Based upon the hypothesis that equine laminitis and navicular disease result from microthrombosis, the inhibitory effects of PTX on inflammatory cytokines, and its inhibitory effects on human platelet aggregation, PTX has been widely used to treat equine endotoxemia, navicular disease, and laminitis. Despite this, the effects of PTX on equine platelet aggregation have not been investigated previously. Objective: PTX decreases platelet aggregation in equine whole blood at concentrations approximating those achieved in horses given clinically relevant doses of PTX. Methods: Seven healthy adult horses from a research herd. Methods: Whole blood impedance aggregometry using whole equine blood incubated with varying concentrations of PTX. Adenosine diphosphate (ADP) and collagen were used to initiate aggregation. Results: The onset time of collagen-induced equine platelet aggregation was significantly shortened by PTX. The maximum slope of resistance change (dR/dt) and total resistance change of collagen-induced platelet aggregation were unaffected by PTX. No effects of PTX on ADP-induced onset time of aggregation, dR/dt, or total resistance change were observed. Conclusions: Our hypothesis is not supported by the results. PTX hastens the onset of collagen-induced platelet aggregation in equine whole blood, but has no effect on the rate of collagen-induced aggregation. PTX does not affect ADP-dependent equine platelet aggregation. Given these findings, PTX may not be a reasonable therapeutic option to decrease platelet aggregation in horses.
Copyright © 2010 by the American College of Veterinary Internal Medicine.
Publication Date: 2010-08-12 PubMed ID: 20707843DOI: 10.1111/j.1939-1676.2010.0574.xGoogle Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research aimed to investigate the effects of pentoxifylline (PTX) on equine platelet aggregation. Contrary to the researchers’ hypothesis, PTX was found to hasten the onset of collagen-induced platelet aggregation in equine whole blood, but had no effect on the rate of aggregation, nor did it affect ADP-dependent platelet aggregation.
Research Objectives
The study aimed to investigate the effects of Pentoxifylline (PTX) on platelet aggregation in equine blood. The researchers hypothesized that PTX would decrease platelet aggregation, based on its known inhibitory effects on human platelet aggregation and inflammatory cytokines. This premise is of interest since PTX is widely used in the treatment of equine endotoxemia, navicular disease, and laminitis, ailments believed to result from microthrombosis.
Methods
- The study involved seven healthy adult horses from a research herd.
- The research used whole blood impedance aggregometry, a method of testing platelet function, with equine blood incubated with varying concentrations of PTX.
- Adenosine diphosphate (ADP) and collagen were used to trigger platelet aggregation for the experiment.
Results
Contrary to the original hypothesis, the results indicated:
- PTX significantly shortened the onset time of collagen-induced equine platelet aggregation.
- However, PTX did not affect the maximum slope of resistance change (dR/dt) and total resistance change of collagen-induced platelet aggregation.
- No effects of PTX on ADP-induced onset time of aggregation, dR/dt, or total resistance change were observed.
Conclusion
From the findings, it appears that the initial hypothesis was incorrect. PTX hastened the onset of collagen-induced platelet aggregation in equine whole blood, but had no effect on the rate of aggregation. Also, PTX did not impact ADP-dependent equine platelet aggregation. Considering these results, the research concludes that PTX may not be a therapeutically effective option to reduce platelet aggregation in horses.
Cite This Article
APA
Kornreich B, Enyeart M, Jesty SA, Nydam DV, Divers T.
(2010).
The effects of pentoxifylline on equine platelet aggregation.
J Vet Intern Med, 24(5), 1196-1202.
https://doi.org/10.1111/j.1939-1676.2010.0574.x Publication
Researcher Affiliations
- Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA. bgk2@cornell.edu
MeSH Terms
- Animals
- Dose-Response Relationship, Drug
- Horses / blood
- Pentoxifylline / pharmacology
- Platelet Aggregation / drug effects
Citations
This article has been cited 3 times.- Thomason JM, Archer TM, Wills RW, Mackin AJ. Effects of pentoxifylline on canine platelet aggregation. Vet Med Sci 2021 Nov;7(6):2178-2184.
- Stokol T, Serpa PBS, Zahid MN, Brooks MB. Unfractionated and Low-Molecular-Weight Heparin and the Phosphodiesterase Inhibitors, IBMX and Cilostazol, Block Ex Vivo Equid Herpesvirus Type-1-Induced Platelet Activation. Front Vet Sci 2016;3:99.
- Miglio A, Falcinelli E, Cappelli K, Mecocci S, Mezzasoma AM, Antognoni MT, Gresele P. Effect of Regular Training on Platelet Function in Untrained Thoroughbreds. Animals (Basel) 2024 Jan 27;14(3).
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
