The effects of stanozolol and boldenone undecylenate on plasma testosterone and gonadotropins and on testis histology in pony stallions.
Abstract: Fifty 2- to 16- yr old pony stallions were randomly assigned to one of five treatments: Group 1, controls (no treatment); Group 2, 0.55 mg/kg stanozolol weekly for 13 treatments; Group 3, 1.1 mg/kg stanozolol every 3 wk for 5 treatments; Group 4, 1.1 mg/kg boldenone undecylenate every 3 wk for 5 treatments; and Group 5, 0.55 boldenone undecylenate weekly for 13 treatments. Mean plasma testosterone levels for Groups 2, 4, and 5 were elevated over controls (P0.05). There were no differences in mean plasma luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels among groups (P>0.05). Daily spermatid production per gram of testicular parenchyma (DSP/gm) in Group 5 was lower than in controls (P0.05). There were no differences among groups (P>0.05) in the percentage of Stage 8 tubules or relative number of Leydig cells. The mean diameter of Leydig cells was less for Group 5 than for controls (P0.05).
Publication Date: 1987-07-01 PubMed ID: 16726297DOI: 10.1016/0093-691x(87)90190-7Google Scholar: Lookup
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Summary
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The research study investigated the effects of stanozolol and boldenone undecylenate on testosterone, gonadotropin levels, and testis histology in pony stallions. The study found that these treatments influenced testosterone levels and testicular function without affecting plasma luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels.
Design and Method
- The study included fifty pony stallions aged 2 to 16 years, which were randomly assigned to five different treatment groups. This randomized controlled trial methodology ensures balance in the groups and minimizes the influence of bias.
- Group 1 was the control group and did not receive any treatment. Groups 2 and 3 received varying doses of stanozolol, while groups 4 and 5 received different doses of boldenone undecylenate. These specific drugs are important as they are known to influence testosterone levels.
Results
- The findings revealed that mean plasma testosterone levels were elevated in Groups 2, 4 and 5 compared to the control group. However, there was no significant difference in testosterone levels between Group 3 and the control group.
- Despite the variations in testosterone levels, there were no significant differences in plasma luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels among any of the groups. These hormones are important players in the normal functioning of the reproductive system.
- Daily spermatid production per gram of testicular parenchyma (DSP/gm) in Group 5 was lower than in the control group, suggesting that boldenone undecylenate may have a detrimental effect on sperm production. However, there was no significant difference in DSP/gm among groups 1 to 4.
- No significant differences were found among the groups in terms of the percentage of Stage 8 tubules or the relative number of Leydig cells, which are responsible for producing testosterone.
- The average diameter of Leydig cells was smaller in Group 5 compared to the control group. This could potentially indicate an effect of the specific dosage of boldenone undecylenate on cell morphology, but further research would be required to confirm this hypothesis.
Conclusion
- The research presents valuable insights into the impact of stanozolol and boldenone undecylenate on various reproductive parameters in pony stallions. It highlights the potential effects of these substances on testosterone levels and testicular function and indicates the need for more detailed investigations into their potential reproductive health implications.
Cite This Article
APA
Garcia MC, Ganjam VK, Blanchard TL, Brown E, Hardin K, Elmore RG, Youngquist RS, Loch WE, Ellersieck MR, Balke JM.
(1987).
The effects of stanozolol and boldenone undecylenate on plasma testosterone and gonadotropins and on testis histology in pony stallions.
Theriogenology, 28(1), 109-119.
https://doi.org/10.1016/0093-691x(87)90190-7 Publication
Researcher Affiliations
- School of Veterinary Medicine, University of Pennsylvania, New Bolton Center, Kennett Square, PA 19348, USA.
Citations
This article has been cited 2 times.- Oda SS, El-Ashmawy IM. Adverse effects of the anabolic steroid, boldenone undecylenate, on reproductive functions of male rabbits. Int J Exp Pathol 2012 Jun;93(3):172-8.
- Koskinen E, Katila T. Effect of 19-norandrostenololylaurate on serum testosterone concentration, libido, and closure of distal radial growth plate in colts. Acta Vet Scand 1997;38(1):59-67.
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