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The evaluation of extracorporeal shock wave therapy on collagenase induced superficial digital flexor tendonitis.

Abstract: Extracorporeal shock wave therapy (ESWT) is being used to treat desmitis and tendonitis in horses. This paper compares the clinical, ultrasonographic and histological characteristics of ESWT treated collagenase induced superficial digital flexor tendon (SDFT) lesions, versus untreated controls. This blinded study utilizes six mature, healthy horses where bilateral forelimb SDFT lesions were induced. One forelimb was treated while the other served as an untreated control. Three shock wave treatments were administered at three week intervals. At weekly intervals, ultrasonograms were used to measure: 1) percentage lesion at the maximum injury zone (MIZ), 2) the grey scale of the SDFT at the MIZ, 3) the percentage disruption of the longitudinal fibres at the MIZ. The data were also summed from 8-20 cm distal to the accessory carpal bone. Measurements of the external width of the SDFT were obtained through the study period. Examinations were performed on four occasions to evaluate heat, response to palpation, presence/character of swelling over the SDFT, and lameness. At the completion of the study all tendons were evaluated histologicalally. The lesion size, grey scale, and longitudinal fibre disruption at the MIZ, and sum of each variable changed significantly over time, however, there was no difference between treated and control groups. Histopathology showed increased neovascularization in treated tendons (p = 0.001). When compared to untreated controls, ESWT did not change the ultrasonographic appearance of the tendons. However, it did increase neovascularization.
Publication Date: 2006-07-01 PubMed ID: 16810352
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  • Evaluation Study
  • Journal Article

Summary

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The research article is about a study on the effects of Extracorporeal Shock Wave Therapy (ESWT) on horses with collagenase induced superficial digital flexor tendonitis, concluding that ESWT did not alter the ultrasonographic appearance of the tendons but increased neovascularization.

Objective of the Study

The study sought to evaluate the clinical, ultrasonographic, and histological effects of Extracorporeal Shock Wave Therapy (ESWT) on horses afflicted with collagenase induced superficial digital flexor tendonitis. Such horses were compared with untreated controls.

Methodology

  • The research was conducted as a blind study using six mature, healthy horses. The horses served as their controls by inducing bilateral forelimb Superficial Digital Flexor Tendon (SDFT) lesions. One forelimb was treated with ESWT, and the other was left untreated, providing a basis for comparison.
  • Three shock wave treatments were administered at three-week intervals to the treated forelimb, while the untreated forelimb was left alone.
  • Ultrasonograms were used weekly to measure the percentage of the lesion at the maximum injury zone (MIZ), the grey scale of the SDFT at the MIZ, the percentage of disruption of longitudinal fibres at the MIZ, and the external width of the SDFT throughout the study.
  • The presence and nature of swelling over the SDFT, the heat, the response to palpation, and the lameness were evaluated four times during the study.
  • At the conclusion of the study, all tendons in the horses were examined histologically to observe the impact of the ESWT on a cellular level.

Findings

  • The study observed that the lesion size, grey scale, and longitudinal fibre disruption at MIZ and the sum of each variable changed significantly over time. However, there was no difference noticed between the ESWT treated group and the untreated controls.
  • The histopathological examination revealed increased neovascularization (the natural formation of new blood vessels) in the ESWT treated tendons. This suggests that while ESWT may not alter the ultrasonographic appearance of the tendons, it may enhance the healing process by promoting blood flow to the area.

Conclusion

While Extracorporeal Shock Wave Therapy (ESWT) did not alter the ultrasonographic appearance of the tendons in this study, the therapy was found to increase neovascularization. This may suggest that ESWT could help in improving the healing process in horses diagnosed with collagenase induced superficial digital flexor tendonitis. Further research could be beneficial in order to explore this potential benefit in more depth.

Cite This Article

APA
Kersh KD, McClure SR, Van Sickle D, Evans RB. (2006). The evaluation of extracorporeal shock wave therapy on collagenase induced superficial digital flexor tendonitis. Vet Comp Orthop Traumatol, 19(2), 99-105.

Publication

ISSN: 0932-0814
NlmUniqueID: 8906319
Country: Germany
Language: English
Volume: 19
Issue: 2
Pages: 99-105

Researcher Affiliations

Kersh, K D
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011-1250, USA.
McClure, S R
    Van Sickle, D
      Evans, R B

        MeSH Terms

        • Analysis of Variance
        • Animals
        • Collagenases / adverse effects
        • Forelimb
        • Horse Diseases / chemically induced
        • Horse Diseases / diagnostic imaging
        • Horse Diseases / therapy
        • Horses
        • Lithotripsy / veterinary
        • Tendinopathy / chemically induced
        • Tendinopathy / diagnostic imaging
        • Tendinopathy / therapy
        • Tendinopathy / veterinary
        • Tendons / blood supply
        • Tendons / diagnostic imaging
        • Tendons / pathology
        • Treatment Outcome
        • Ultrasonography

        Citations

        This article has been cited 9 times.
        1. Poenaru D, Sandulescu MI, Cinteza D. Biological effects of extracorporeal shockwave therapy in tendons: A systematic review. Biomed Rep 2023 Feb;18(2):15.
          doi: 10.3892/br.2022.1597pubmed: 36684664google scholar: lookup
        2. Chen Y, Lyu K, Lu J, Jiang L, Zhu B, Liu X, Li Y, Liu X, Long L, Wang X, Xu H, Wang D, Li S. Biological response of extracorporeal shock wave therapy to tendinopathy in vivo (review). Front Vet Sci 2022;9:851894.
          doi: 10.3389/fvets.2022.851894pubmed: 35942112google scholar: lookup
        3. Wuerfel T, Schmitz C, Jokinen LLJ. The Effects of the Exposure of Musculoskeletal Tissue to Extracorporeal Shock Waves. Biomedicines 2022 May 6;10(5).
          doi: 10.3390/biomedicines10051084pubmed: 35625821google scholar: lookup
        4. Gaesser AM, Underwood C, Linardi RL, Even KM, Reef VB, Shetye SS, Mauck RL, King WJ, Engiles JB, Ortved KF. Evaluation of Autologous Protein Solution Injection for Treatment of Superficial Digital Flexor Tendonitis in an Equine Model. Front Vet Sci 2021;8:697551.
          doi: 10.3389/fvets.2021.697551pubmed: 34291103google scholar: lookup
        5. Seabaugh KA, Thoresen M, Giguère S. Extracorporeal Shockwave Therapy Increases Growth Factor Release from Equine Platelet-Rich Plasma In Vitro. Front Vet Sci 2017;4:205.
          doi: 10.3389/fvets.2017.00205pubmed: 29270410google scholar: lookup
        6. Visco V, Vulpiani MC, Torrisi MR, Ferretti A, Pavan A, Vetrano M. Experimental studies on the biological effects of extracorporeal shock wave therapy on tendon models. A review of the literature. Muscles Ligaments Tendons J 2014 Jul;4(3):357-61.
          pubmed: 25489555
        7. Spaas JH, Guest DJ, Van de Walle GR. Tendon regeneration in human and equine athletes: Ubi Sumus-Quo Vadimus (where are we and where are we going to)?. Sports Med 2012 Oct 1;42(10):871-90.
          doi: 10.1007/BF03262300pubmed: 22963225google scholar: lookup
        8. Qiu Z, Wang J, Zhang Y, Liu X, Wei C, Ma T. Extracorporeal shock wave therapy for equine musculoskeletal disorders: from biological mechanisms to clinical applications. Front Vet Sci 2025;12:1719123.
          doi: 10.3389/fvets.2025.1719123pubmed: 41487475google scholar: lookup
        9. Giraldo A, Koch TG, Madan P, Lepage S, Monteith G, Alizadeh AH, Tran A, Mortagy N, Koenig JB. Effect of extracorporeal shockwave therapy on the immunomodulatory and anti-inflammatory properties of cultured equine umbilical cord blood mesenchymal stromal cells. Can J Vet Res 2024 Jul;88(3):87-93.
          pubmed: 38988333