The influence of exercise on serum enzyme levels in the horse.
Abstract: A group of clinically normal horses was subjected to controlled strenuous exercise. Elevated serum concentrations of lactic dehydrogenase, aldolase and creatine kinase were observed after exercise but no significant change in serum glutamic-oxalacetic transaminase was noted. These changes were reduced by repeated exposure to exercise suggesting that measurement of serum enzyme elevations, particularly creatine kinase, might be a useful index of fitness in the horse. Administration of prednisolone prior to exercise also reduced these changes. Since the serum enzyme concentrations had returned to normal within 72 hours of exercise, and since the cytoplasmic enzyme glutamic oxalacetic transaminase was not released from the tissues this supported the hypothesis that efflux of intracellular enzymes into the circulation was due to a temporary selective change in cell membrane permeability rather than to tissue necrosis.
Publication Date: 1975-07-01 PubMed ID: 1157811DOI: 10.1111/j.2042-3306.1975.tb03258.xGoogle Scholar: Lookup
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- Journal Article
Summary
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The research study explored how strenuous exercise affects serum enzyme levels in horses and found that certain enzyme levels increased post-exercise and normalized within 72 hours, suggesting physical exercise influences cell membrane’s permeability.
Study Methodology
- The study was conducted on a group of clinically normal horses which were subjected to controlled strenuous exercise.
- The researchers then monitored the serum enzyme levels of these horses specifically looking at lactic dehydrogenase, aldolase, creatine kinase, and serum glutamic-oxalacetic transaminase.
- The researchers also conducted a test where prednisolone was administered to the horses before exercising.
Study Findings
- Post-exercise, the researchers observed elevated serum concentrations of lactic dehydrogenase, aldolase, and creatine kinase. These elevations, however, didn’t significantly change the level of serum glutamic-oxalacetic transaminase.
- These changes in enzyme levels decreased with repeated exposure to exercise suggesting that these changes could serve as a measure of fitness in horses, particularly the creatine kinase levels.
- Administering prednisolone to the horses before exercising also reduced these enzymatic changes.
- The serum enzyme concentrations returned to normal within 72 hours after exercising. The researchers hypothesized that this was due to a temporary selective change in the cell membrane permeability and not due to tissue necrosis as the cytoplasmic enzyme glutamic oxalacetic transaminase was not released from the tissues.
Conclusion and Implications
- The findings of this research suggested that strenuous exercise caused temporary increases in certain serum enzyme levels in horses and this change was related to a selective alteration in cell membrane permeability rather than tissue damage.
- This discovery of elevated enzyme levels following exercise could be a crucial metric for assessing fitness levels in horses and understanding physical impacts on them for better healthcare and training strategies.
Cite This Article
APA
Anderson MG.
(1975).
The influence of exercise on serum enzyme levels in the horse.
Equine Vet J, 7(3), 160-165.
https://doi.org/10.1111/j.2042-3306.1975.tb03258.x Publication
Researcher Affiliations
MeSH Terms
- Animals
- Aspartate Aminotransferases / blood
- Creatine Kinase / blood
- Enzymes / blood
- Female
- Fructose-Bisphosphate Aldolase / blood
- Horses / blood
- L-Lactate Dehydrogenase / blood
- Male
- Physical Conditioning, Animal
- Prednisolone / pharmacology
Citations
This article has been cited 6 times.- Buckley P, Buckley DJ, Freire R, Hughes KJ. Pre-race and race management impacts serum muscle enzyme activity in Australian endurance horses.. Equine Vet J 2022 Sep;54(5):895-904.
- Latham CM, Dickson EC, Owen RN, Larson CK, White-Springer SH. Complexed trace mineral supplementation alters antioxidant activities and expression in response to trailer stress in yearling horses in training.. Sci Rep 2021 Apr 1;11(1):7352.
- Assenza A, Marafioti S, Congiu F, Giannetto C, Fazio F, Bruschetta D, Piccione G. Serum muscle-derived enzymes response during show jumping competition in horse.. Vet World 2016 Mar;9(3):251-5.
- Stefánsdóttir GJ, Ragnarsson S, Gunnarsson V, Jansson A. Physiological response to a breed evaluation field test in Icelandic horses.. Animal 2014 Mar;8(3):431-9.
- Perez R, Recabarren SE, Valdes P, Hetz E. Biochemical and physiological parameters and estimated work output in draught horses pulling loads for long periods.. Vet Res Commun 1992;16(3):231-46.
- Guy PS, Snow DH. The effect of training and detraining on muscle composition in the horse.. J Physiol 1977 Jul;269(1):33-51.
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