The influence of spasmolytic agents on heart rate variability and gastrointestinal motility in normal horses.
Abstract: The effects of hyoscine-N-butylbromide (hyoscine) and propantheline-bromide (propantheline) on heart rate (HR), HR variability (HRV) and gastrointestinal tract (GIT) contractions in the normal horse were determined. Five adult horses had ECG recordings for 180 min after treatment with propantheline (100mg), hyoscine (120 mg) or saline. Both propantheline and hyoscine reduced GIT sounds, with propantheline having a longer duration of effect (≥120 min). Both drugs elevated HR relative to the control baseline period (P<0.05), with the effects of propantheline again being of longer duration. HRV analysis indicated that propantheline suppressed Total Power (P<0.05), and both the high frequency (HF) and low frequency (LF) components of the power spectral analysis for up to 60-90 min post treatment. Hyoscine had no effect on HRV Total Power but reduced the HF component for 30 min after drug injection. Time domain variables correlated with Total Power and HF data (P<0.01). The marked effect of these compounds on parasympathetic control of cardiac and GIT function in normal horses should be taken into consideration when evaluating a clinical response to these agents.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Publication Date: 2012-06-09 PubMed ID: 22683390DOI: 10.1016/j.rvsc.2012.05.003Google Scholar: Lookup
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- Journal Article
- Randomized Controlled Trial
- Research Support
- Non-U.S. Gov't
Summary
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This study examines how hyoscine-N-butylbromide (hyoscine) and propantheline-bromide (propantheline) affect heart rate, gastrointestinal tract contractions, and heart rate variability in healthy horses.
Methodology and Drug Effects
- The research was conducted on five adult horses. Electrocardiogram (ECG) recordings were taken for three hours following treatment with either propantheline, hyoscine, or saline solution as a control.
- Both hyoscine and propantheline led to a decrease in the sounds made by the gastrointestinal tract. The effect of propantheline lasted longer, with effects lasting at least two hours.
- Both drugs raised the heart rate compared to the baseline period prior to treatment, and propantheline’s effects again lasted longer.
Impact on Heart Rate Variability
- The HRV analysis revealed that propantheline decreased Total Power, which is a metric representing the cumulative power of all cyclical components present in a particular series. This effect lasted for 60 to 90 minutes after the treatment.
- Both the high frequency (HF) and low frequency (LF) components of the power spectral analysis were reduced by propantheline.
- Hyoscine, on the other hand, did not affect the HRV Total Power but did reduce the high-frequency component for half an hour following the injection.
- The time domain variables correlated with Total Power and high frequency data, confirming the significant impact of both drugs on these metrics.
Implication of the Study
- The findings of the study clearly indicate that both hyoscine and propantheline have considerable effects on heart and gastrointestinal function, notably in their influence over parasympathetic controls.
- These effects should therefore be taken into account when evaluating a clinical response to these drugs in horses.
- This work contributes to our understanding of the physiological effects of these antispasmodic compounds, and provides important guidance for their application in equine medicine.
Cite This Article
APA
Sundra TM, Harrison JL, Lester GD, Raidal SL, Phillips JK.
(2012).
The influence of spasmolytic agents on heart rate variability and gastrointestinal motility in normal horses.
Res Vet Sci, 93(3), 1426-1433.
https://doi.org/10.1016/j.rvsc.2012.05.003 Publication
Researcher Affiliations
- School of Veterinary and Biomedical Science, Faculty of Health Sciences, Murdoch University, Perth, 6150 WA, Australia.
MeSH Terms
- Animals
- Butylscopolammonium Bromide / pharmacology
- Cross-Over Studies
- Gastrointestinal Motility / drug effects
- Heart Rate / drug effects
- Horses / physiology
- Parasympatholytics / pharmacology
- Propantheline / pharmacology
Citations
This article has been cited 3 times.- Tsai FF, Liu CM, Wang HP, Yeh JR, Fan SZ. Deceleration capacity of heart rate variability as a predictor of sedation related hypotension.. Sci Rep 2021 May 25;11(1):10850.
- Gehlen H, Faust MD, Grzeskowiak RM, Trachsel DS. Association Between Disease Severity, Heart Rate Variability (HRV) and Serum Cortisol Concentrations in Horses with Acute Abdominal Pain.. Animals (Basel) 2020 Sep 2;10(9).
- Lenoir A, Trachsel DS, Younes M, Barrey E, Robert C. Agreement between Electrocardiogram and Heart Rate Meter Is Low for the Measurement of Heart Rate Variability during Exercise in Young Endurance Horses.. Front Vet Sci 2017;4:170.
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