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Veterinary journal (London, England : 1997)2007; 177(2); 178-191; doi: 10.1016/j.tvjl.2007.07.033

The oxidant/antioxidant equilibrium in horses.

Abstract: Since "free radical research" started in 1954, understanding the role of oxidants and antioxidants in physiological and pathological conditions has increased continuously. Oxidants are essentially generated by metabolic enzymes, inflammatory cells and mitochondrial electron leakage; they are indispensable for the cellular redox regulation and may, under certain conditions, have a pro-inflammatory stimulatory role. Endogenous and exogenous antioxidants counterbalance the oxidative processes and so maintain the oxidant/antioxidant equilibrium. Excessive oxidant generation or antioxidant insufficiency can lead to oxidative stress. The aims of this review are: (1) to provide an insight into the concept of the oxidant/antioxidant equilibrium by briefly introducing the oxidant and the antioxidant systems; (2) to describe how the oxidant/antioxidant equilibrium or oxidative stress can be evaluated in horses, and (3) to summarise current knowledge about oxidative stress in equine medicine and equine exercise physiology.
Publication Date: 2007-09-25 PubMed ID: 17897849DOI: 10.1016/j.tvjl.2007.07.033Google Scholar: Lookup
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Summary

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The research article provides an overview of the role of oxidants and antioxidants in maintaining the body’s equilibrium and discusses how imbalance in this system can result in oxidative stress, especially in horses. It also outlines methods to evaluate this balance or stress in horses, and summarizes existing understanding about oxidative stress in equine medicine and exercise physiology.

Oxidants and Antioxidants

The article begins by explaining the role of oxidants and antioxidants in physiological and pathological conditions. Oxidants are usually produced by metabolic enzymes, inflammatory cells, and mitochondrial electron leakage.

  • Oxidants play a crucial role in cellular redox regulation and under certain circumstances, they can stimulate pro-inflammatory conditions.
  • Endogenous and exogenous antioxidants counterbalance oxidative processes

While both oxidants and antioxidants are indispensable to maintaining the body’s equilibrium, an imbalance between the two – either due to excessive oxidant generation or insufficient antioxidants – can lead to oxidative stress.

Evaluating Oxidant/Antioxidant Equilibrium in Horses

The research further explores how to assess the oxidant/antioxidant balance in horses. An understanding of this balance is crucial, as oxidative stress can have significant impacts on the health and performance of horses, especially in equine sports.

Oxidative Stress in Equine Medicine

Finally, the article summarizes our current knowledge of oxidative stress in the field of equine medicine and exercise physiology. This includes the potential implications of oxidative stress on the overall health of horses, as well as on their performance in athletic pursuits. Understanding of this balance and its impacts can facilitate the development of better care protocols and potentially reproductive performance enhancement strategies for horses.

Cite This Article

APA
Kirschvink N, de Moffarts B, Lekeux P. (2007). The oxidant/antioxidant equilibrium in horses. Vet J, 177(2), 178-191. https://doi.org/10.1016/j.tvjl.2007.07.033

Publication

ISSN: 1090-0233
NlmUniqueID: 9706281
Country: England
Language: English
Volume: 177
Issue: 2
Pages: 178-191

Researcher Affiliations

Kirschvink, Nathalie
  • Animal Physiology, Department for Veterinary Medicine, Faculty of Sciences, University of Namur, Belgium. nathalie.kirschvink@fundp.ac.be
de Moffarts, Brieuc
    Lekeux, Pierre

      MeSH Terms

      • Animals
      • Antioxidants / metabolism
      • Horse Diseases / metabolism
      • Horses
      • Oxidants / metabolism

      Citations

      This article has been cited 35 times.