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Home / Equine Research Bank / Animals (Basel) / The Oxidative Stress Markers of Horses-the Comparison with O...
Animals : an open access journal from MDPI2020; 10(4); 617; doi: 10.3390/ani10040617

The Oxidative Stress Markers of Horses-the Comparison with Other Animals and the Influence of Exercise and Disease.

Abstract: Diacron-reactive oxygen metabolite (d-ROM) and biological antioxidant potential (BAP) levels in the serum of horses were measured (ponies, = 15; thoroughbred, = 31; other full-sized horses, = 7). The mean d-ROM levels in horses were significantly higher ( < 0.001) than those in dairy cattle ( = 25) and dogs ( = 31). However, d-ROM levels in horses were lower than the standard levels reported in humans. When d-ROM and BAP levels were plotted graphically, the points for horses with a disease (ringbone in 1 Japanese sports horse, cellulitis in 1 thoroughbred, melanoma in 1 Lipizzaner) fell outside the group of points for other (non-diseased) horses. A similar separation was seen (using data from other authors) for a horse with , a horse following castration surgery, and a mare following delivery. These results, comparing horses, other animals, and humans, are interesting from the standpoint of comparative medicine, and they contribute to the sparse literature available on d-ROM and BAP levels in animals. Because the level of d-ROM and BAP levels were changed depending on the situation of health, those indexes are promising as indices of health in horses.
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Publication Date: 2020-04-03 PubMed ID: 32260122PubMed Central: PMC7222798DOI: 10.3390/ani10040617Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research investigates the oxidative stress markers in horses, how they compare with other animals, and the impact of exercise and disease on these markers. The analysis of Diacron-reactive oxygen metabolite (d-ROM) and biological antioxidant potential (BAP) levels offers intriguing insights into horses’ health.

Overview of The Study

  • The study focused on oxidative stress markers — specifically Diacron-reactive oxygen metabolite (d-ROM), and biological antioxidant potential (BAP) — in horses.
  • The scientists measured these markers in various types of horses, including ponies, thoroughbreds, and other full-sized horses, to evaluate their antioxidant defense mechanism, and how this can be influenced by disease or exercise.
  • The measurements from horses were then compared to oxidative stress markers from other animals, such as dogs and dairy cattle, and to the standard measurements reported in humans.

Research Findings

  • The results suggested that horses have significantly higher d-ROM levels than dairy cattle and dogs, which suggests that horses may produce more reactive oxygen species or have less efficient antioxidant systems.
  • However, these levels were found to be lower than the standard levels reported in humans.
  • Also, the markers deviated in horses diagnosed with diseases when compared to non-diseased horses.
  • A similar trend was noticed in a horse post-castration surgery and a mare after delivery. This suggests that the markers can indicate health alterations in horses.

Significance and Conclusions

  • This study contributes to the sparse research data available on d-ROM and BAP levels in animals, particularly horses.
  • The deviations in the oxidative stress markers in horses with health complications suggest that these markers can be used as indicators of health status in horses.
  • The study carries strong importance for comparative medicine, and could open pathways for health monitoring and preventive healthcare in animals.

Cite This Article

APA
Shono S, Gin A, Minowa F, Okubo K, Mochizuki M. (2020). The Oxidative Stress Markers of Horses-the Comparison with Other Animals and the Influence of Exercise and Disease. Animals (Basel), 10(4), 617. https://doi.org/10.3390/ani10040617

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 10
Issue: 4
PII: 617

Researcher Affiliations

Shono, Saori
  • Department of Applied Science, School of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University, Tokyo 180-8602, Japan.
Gin, Azusa
  • Department of Applied Science, School of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University, Tokyo 180-8602, Japan.
Minowa, Fumiko
  • Minowa Horse Clinic, Tokyo 144-0033, Japan.
Okubo, Kimihiro
  • Department of Otolaryngology, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8602, Japan.
Mochizuki, Mariko
  • Department of Applied Science, School of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University, Tokyo 180-8602, Japan.

Grant Funding

  • 23580430 / the Ministry of Education, Science, Sports, Culture and Technology of Japan. :

Conflict of Interest Statement

The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

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Citations

This article has been cited 7 times.
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