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Home / Equine Research Bank / J Vet Pharmacol Ther / The pharmacokinetics and antiparasitic activity of ivermecti...
Journal of veterinary pharmacology and therapeutics2020; 44(1); 11-17; doi: 10.1111/jvp.12924

The pharmacokinetics and antiparasitic activity of ivermectin in Hutsul and Toric horses.

Abstract: The aim of this study was to compare the pharmacokinetics of ivermectin and its antiparasitic activity in two horse breeds. Eight Hutsul and 14 Toric horses were administered ivermectin orally at a dose of 0.2 mg/kg body weight. Blood samples were collected for 96 hr, and faecal samples were collected one day before and on days 14 and 21 after drug administration. Ivermectin concentrations in plasma samples were determined by high-performance liquid chromatography. Ivermectin concentration was significantly higher in Toric than in Hutsul horses 90 min after ivermectin administration and was maintained at higher level for up to 96 hr. The area under the concentration versus the time curve from 0 to the last sampling point (AUC ) and the maximum plasma concentration (C ) were significantly higher in Toric than in Hutsul horses (1792.09 ± 246.22 μg × hr/L vs. 716.99 ± 255.81 μg × hr/L and 62.72 ± 17.97 ng/ml vs. 35.34 ± 13.61 ng/ml, respectively). No parasitic eggs were found in the faecal samples collected from both groups of horses on days 14 and 21 after drug administration. The obtained results indicate that although the pharmacokinetics of ivermectin may differ significantly between horse breeds, these differences do not affect the effectiveness of therapy.
© 2020 John Wiley & Sons Ltd.
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Publication Date: 2020-10-25 PubMed ID: 33103252DOI: 10.1111/jvp.12924Google Scholar: Lookup
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  • Clinical Trial
  • Veterinary
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The study discusses a comparison in two breeds of horses, Hutsul and Toric, of the blood concentration and antiparasitic effects of the drug ivermectin when administered orally. The findings suggest that while significant variances in drug blood levels were observed between the two breeds, the efficacy of the drug remains constant.

Introduction

  • In this research study, the authors investigated the pharmacokinetics (how drugs are absorbed, distributed, metabolised, and excreted in the body) and antiparasitic effectiveness of the drug ivermectin in two horse breeds – Hutsul and Toric.
  • The primary aim of the study was to identify whether different horse breeds demonstrated different responses to the same dosage of the drug both in terms of pharmacokinetics and its effect on parasitic activity.

Methodology

  • The study involved 8 Hutsul and 14 Toric horses. Ivermectin was administered orally at a dose of 0.2 mg/kg of body weight.
  • Following administration, blood and faecal samples were collected from each horse over a period of 96 hours and 21 days respectively.
  • Ivermectin concentrations in plasma samples were measured using high-performance liquid chromatography, an analytical chemistry technique.

Results

  • The concentration of Ivermectin was found to be significantly higher in Toric horses than in Hutsul horses 90 minutes post-administration. This higher concentration persisted up to 96 hours.
  • Additional parameters such as “Area under the curve” (AUC), which provides a measure of the drug exposure over time, and “maximum plasma concentration” were also significantly higher in Toric horses.
  • However, the antiparasitic effectiveness was observed to be the same in both breeds of horses, with no parasitic eggs found in faecal samples collected on days 14 and 21 post-administration of the drug.

Conclusion

  • The study concludes that though there may be noticeable differences in the pharmacokinetics of ivermectin between horse breeds, these differences do not influence the therapeutic effectiveness of the drug.
  • By understanding the pharmacokinetics of a drug in different breeds of a species, researchers and veterinarians could make better therapeutic decisions and dosage adjustments if necessary.

Cite This Article

APA
Vyniarska A, Ziółkowski H, Madej-Śmiechowska H, Jaroszewski JJ. (2020). The pharmacokinetics and antiparasitic activity of ivermectin in Hutsul and Toric horses. J Vet Pharmacol Ther, 44(1), 11-17. https://doi.org/10.1111/jvp.12924

Publication

Journal of veterinary pharmacology and therapeutics
ISSN: 1365-2885
NlmUniqueID: 7910920
Country: England
Language: English
Volume: 44
Issue: 1
Pages: 11-17

Researcher Affiliations

Vyniarska, Alla
  • Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Stepan Gzhytskyi National University of Veterynary and Biotechnologies, Lviv, Ukraine.
Ziółkowski, Hubert
  • Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Madej-Śmiechowska, Hanna
  • Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Jaroszewski, Jerzy J
  • Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.

MeSH Terms

  • Animals
  • Antiparasitic Agents / pharmacokinetics
  • Antiparasitic Agents / therapeutic use
  • Area Under Curve
  • Feces / parasitology
  • Half-Life
  • Horse Diseases / drug therapy
  • Horse Diseases / parasitology
  • Horses / classification
  • Horses / genetics
  • Horses / metabolism
  • Ivermectin / pharmacokinetics
  • Ivermectin / therapeutic use
  • Parasite Egg Count / veterinary
  • Parasitic Diseases, Animal / drug therapy

Grant Funding

  • 010/RID/2018/19 / Ministerstwo Nauki i Szkolnictwa Wyu017cszego

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Citations

This article has been cited 2 times.
  1. Carrillo Heredero AM, Segato G, Menotta S, Faggionato E, Vismarra A, Genchi M, Bertini S. A New Method for Ivermectin Detection and Quantification through HPLC in Organic Matter (Feed, Soil, and Water).. J Anal Methods Chem 2023;2023:6924263.
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  2. Malsa J, Courtot É, Boisseau M, Dumont B, Gombault P, Kuzmina TA, Basiaga M, Lluch J, Annonay G, Dhorne-Pollet S, Mach N, Sutra JF, Wimel L, Dubois C, Guégnard F, Serreau D, Lespine A, Sallé G, Fleurance G. Effect of sainfoin (Onobrychis viciifolia) on cyathostomin eggs excretion, larval development, larval community structure and efficacy of ivermectin treatment in horses.. Parasitology 2022 Sep;149(11):1439-1449.
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