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The Veterinary clinics of North America. Equine practice2010; 26(1); 115-124; doi: 10.1016/j.cveq.2010.01.003

The pharmacologic basis for the treatment of developmental and acute laminitis.

Abstract: The treatment of laminitis has been fraught with confusion and controversy for several decades, mainly because of a lack of understanding of the pathophysiology of the disease process. However, recent advances in laminitis research have greatly improved our understanding of the disease process. This article discusses the various treatment options for laminitis in the context of the findings of recent scientific investigations of laminitis pathophysiology.
Publication Date: 2010-04-13 PubMed ID: 20381740DOI: 10.1016/j.cveq.2010.01.003Google Scholar: Lookup
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Summary

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The article delves into recent advances in understanding and treating laminitis, offering an overview of available treatments based on the latest scientific findings about the disease’s pathsophysiology.

Understanding Laminitis

  • Laminitis is a disease afflicting the feet of hoofed animals like horses and cattle. It’s marked by the inflammation of the sensitive laminae (tissue structures) that connect the animal’s hoof and skeleton.
  • Understanding and treating laminitis has historically been challenging due to the complex and often poorly understood disease process. This paper suggests that recent scientific advances have begun to shed more light on the underlying pathophysiology of the disease, potentially paving the way for improved treatments.

New Perspectives on Laminitis Pathophysiology

  • The content of the paper revolves around recent discoveries in the field of laminitis research, which have brought a number of significant insights about the disease and its underlying mechanisms.
  • In light of these new findings, the paper reconsiders traditional treatment strategies for laminitis, presenting them in the context of the most recent scientific understanding of the disease.

Treatment Options for Laminitis

  • In light of this new understanding of the disease, the study reevaluates the available treatment options for laminitis. It discusses various therapeutic strategies and suggests that their efficacy may be better understood in the context of the disease’s underlying pathophysiology.
  • Increased understanding has not only shed light on the effectivity of various treatments but also brought the promise of developing new therapeutic strategies. This section of the study looks critically at these treatments, aided by the newfound knowledge about laminitis.

Cite This Article

APA
Belknap JK. (2010). The pharmacologic basis for the treatment of developmental and acute laminitis. Vet Clin North Am Equine Pract, 26(1), 115-124. https://doi.org/10.1016/j.cveq.2010.01.003

Publication

ISSN: 1558-4224
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 26
Issue: 1
Pages: 115-124

Researcher Affiliations

Belknap, James K
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus, OH 43210, USA. james.belknap@cvm.osu.edu

MeSH Terms

  • Acute Disease
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Anticoagulants / therapeutic use
  • Foot Diseases / drug therapy
  • Foot Diseases / physiopathology
  • Foot Diseases / veterinary
  • Hoof and Claw / blood supply
  • Hoof and Claw / pathology
  • Horse Diseases / drug therapy
  • Horse Diseases / physiopathology
  • Horses
  • Inflammation / drug therapy
  • Inflammation / physiopathology
  • Inflammation / veterinary
  • Vasodilator Agents / therapeutic use

Citations

This article has been cited 5 times.
  1. Castro-Mesa AF, Resende Faleiros R, Martínez-Aranzales JR. Transmural Ultrasonography in the Evaluation of Horse Hoof Internal Structures: Comparative Quantitative Findings-Part 2.. Animals (Basel) 2023 Jul 11;13(14).
    doi: 10.3390/ani13142267pubmed: 37508045google scholar: lookup
  2. Burns TA, Watts MR, Belknap JK, van Eps AW. Digital lamellar inflammatory signaling in an experimental model of equine preferential weight bearing.. J Vet Intern Med 2023 Mar;37(2):681-688.
    doi: 10.1111/jvim.16662pubmed: 36840365google scholar: lookup
  3. Mitchell CF, Fugler LA, Eades SC. The management of equine acute laminitis.. Vet Med (Auckl) 2015;6:39-47.
    doi: 10.2147/VMRR.S39967pubmed: 30101095google scholar: lookup
  4. Lancaster LS, Bowker RM. Acupuncture Points of the Horse's Distal Thoracic Limb: A Neuroanatomic Approach to the Transposition of Traditional Points.. Animals (Basel) 2012 Sep 17;2(3):455-71.
    doi: 10.3390/ani2030455pubmed: 26487033google scholar: lookup
  5. Mathison RD, Davison JS, Befus AD, Gingerich DA. Salivary gland derived peptides as a new class of anti-inflammatory agents: review of preclinical pharmacology of C-terminal peptides of SMR1 protein.. J Inflamm (Lond) 2010 Sep 28;7:49.
    doi: 10.1186/1476-9255-7-49pubmed: 20920210google scholar: lookup