FREE SHIPPING over $40
OVER 9000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
Home / Equine Research Bank / Pigment Cell Res / The study of cutaneous melanomas in Camargue-type gray-skinn...
Pigment cell research2000; 13(1); 39-46; doi: 10.1034/j.1600-0749.2000.130108.x

The study of cutaneous melanomas in Camargue-type gray-skinned horses (1): clinical-pathological characterization.

Abstract: The clinical and pathological characteristics of cutaneous melanomas occurring in Camargue-type gray-skinned horses are reported. Examination of 83 tumor-bearing horses revealed that the tumors occurred most frequently underneath the tail (93.9%) and at high rates in the peri-anal region (43.0%), the lips (33.0%), and the eyelids (24.0%), but rarely in the vulva (3.8%). Tumorous lesions were characterized by the presence of either hemispheric nodules or large infiltrated plaques, or their combinations. Microscopic examination indicated that tumorous lesions were composed mostly of melanocytes and numerous melanophages and that component cells manifested a remarkable cellular atypia with anisocytosis and anisokarinosis. Pathological examination of lesions corresponding to earlier stages of the tumors disclosed that tumor formation and its related melanogenesis occurred in close topographical association with apocrine sweat glands, but not at the dermal-epidermal junction. Larger nodules of the tumors were often composed of a concentric deposition of cell layers, each being separated by dermal components from the epidermis. Because of the absence of their tropism toward the epidermis and their multiloculation, horse melanomas are considered to be different in their pathological characteristics from human melanomas.
Get Full Text
Publication Date: 2000-04-13 PubMed ID: 10761995DOI: 10.1034/j.1600-0749.2000.130108.xGoogle Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research examines the clinical and pathological traits of skin melanomas that are typically found in Camargue-type gray-skinned horses. It was discovered that these tumors are most commonly found under the tail and also frequently in the peri-anal area, lips, and eyelids.

Clinical Observations

  • The study was conducted on 83 horses that had cutaneous melanomas.
  • The research found that the tumors most frequently transpired underneath the tail (93.9%) of the horses and in other body parts such as the peri-anal region (43.0%), the lips (33.0%), and the eyelids (24.0%).
  • Interestingly, the occurrence of these tumors in the vulva region was quite rare (3.8%).
  • The physical traits of the tumorous lesions included the presence of hemispheric nodules, large infiltrates plaques, or a combination of both.

Microscopic and Pathological Examination

  • A detailed microscopic examination of the tumorous lesions showed these were primarily comprised of melanocytes and numerous melanophages.
  • The component cells exhibited significant cellular atypia, characterized by anisocytosis and anisokarinosis.
  • The pathological evaluation further depicted that the formation of the tumors and related melanogenesis appeared closely associated with apocrine sweat glands, rather than the dermal-epidermal junction.
  • Larger nodules of the tumors were often composed of a concentric deposition of cell layers, which were all separated by dermal components from the epidermis.

Comparison with Human Melanomas

  • A notable observation from the study was that, contrary to human melanomas, horse melanomas did not show a tropism toward the epidermis.
  • The multiloculation of these horse melanomas further verified their unique pathological characteristics, differing from human melanomas.

The research signifies an important contribution in the field of veterinary oncology, providing insights into the unique behavior and characteristics of melanomas in Camargue-type gray-skinned horses.

Cite This Article

APA
Fleury C, Bérard F, Balme B, Thomas L. (2000). The study of cutaneous melanomas in Camargue-type gray-skinned horses (1): clinical-pathological characterization. Pigment Cell Res, 13(1), 39-46. https://doi.org/10.1034/j.1600-0749.2000.130108.x

Publication

Pigment cell research
ISSN: 0893-5785
NlmUniqueID: 8800247
Country: Denmark
Language: English
Volume: 13
Issue: 1
Pages: 39-46

Researcher Affiliations

Fleury, C
  • INSERM U346, Laboratoire de Glycobiologie de la Progression Tumorale (appliquée au mélanome), UFR de médecine Lyon Sud-165, Oullins, France.
Bérard, F
    Balme, B
      Thomas, L

        MeSH Terms

        • Animals
        • Apocrine Glands / pathology
        • Color
        • Eyelid Neoplasms / pathology
        • Eyelid Neoplasms / veterinary
        • Female
        • Horse Diseases / pathology
        • Horses
        • Male
        • Melanocytes / pathology
        • Melanoma / pathology
        • Melanoma / veterinary
        • Pigments, Biological
        • Skin Neoplasms / pathology
        • Skin Neoplasms / veterinary

        Citations

        This article has been cited 13 times.
        1. Labelle AL, Gemensky Metzler AM, McMullen RJ Jr, Wiggans KT, Labelle P, Hamor RE. Equine intraocular melanocytic neoplasia. Can Vet J 2024 Oct;65(10):1048-1054.
          pubmed: 39355695
        2. Zscherpe P, Kalbitz J, Weber LA, Paschke R, Mäder K, von Rechenberg B, Cavalleri JV, Meißner J, Klein K. Potent drug delivery enhancement of betulinic acid and NVX-207 into equine skin in vitro - a comparison between a novel oxygen flow-assisted transdermal application device and microemulsion gels. BMC Vet Res 2024 May 16;20(1):202.
          doi: 10.1186/s12917-024-04064-1pubmed: 38755639google scholar: lookup
        3. Tesena P, Kingkaw A, Phaonakrop N, Roytrakul S, Limudomporn P, Vongsangnak W, Kovitvadhi A. Faecal Proteomics and Functional Analysis of Equine Melanocytic Neoplasm in Grey Horses. Vet Sci 2022 Feb 21;9(2).
          doi: 10.3390/vetsci9020094pubmed: 35202347google scholar: lookup
        4. Weber LA, Delarocque J, Feige K, Kietzmann M, Kalbitz J, Meißner J, Paschke R, Cavalleri JV. Effects of Topically Applied Betulinic Acid and NVX-207 on Melanocytic Tumors in 18 Horses. Animals (Basel) 2021 Nov 13;11(11).
          doi: 10.3390/ani11113250pubmed: 34827981google scholar: lookup
        5. Battaglia L, Scomparin A, Dianzani C, Milla P, Muntoni E, Arpicco S, Cavalli R. Nanotechnology Addressing Cutaneous Melanoma: The Italian Landscape. Pharmaceutics 2021 Oct 4;13(10).
          doi: 10.3390/pharmaceutics13101617pubmed: 34683910google scholar: lookup
        6. Weber LA, Funtan A, Paschke R, Delarocque J, Kalbitz J, Meißner J, Feige K, Kietzmann M, Cavalleri JV. In vitro assessment of triterpenoids NVX-207 and betulinyl-bis-sulfamate as a topical treatment for equine skin cancer. PLoS One 2020;15(11):e0241448.
          doi: 10.1371/journal.pone.0241448pubmed: 33151949google scholar: lookup
        7. van der Weyden L, Brenn T, Patton EE, Wood GA, Adams DJ. Spontaneously occurring melanoma in animals and their relevance to human melanoma. J Pathol 2020 Sep;252(1):4-21.
          doi: 10.1002/path.5505pubmed: 32652526google scholar: lookup
        8. Horak V, Palanova A, Cizkova J, Miltrova V, Vodicka P, Kupcova Skalnikova H. Melanoma-Bearing Libechov Minipig (MeLiM): The Unique Swine Model of Hereditary Metastatic Melanoma. Genes (Basel) 2019 Nov 9;10(11).
          doi: 10.3390/genes10110915pubmed: 31717496google scholar: lookup
        9. Steinmetz A, Gittel C, Böttcher D, Lapko L, Offhaus J. The use of a combined sliding skin graft and a free labial mucocutaneous graft for reconstruction of the equine upper eyelid after full-thickness excision of a melanoma. Clin Case Rep 2019 Mar;7(3):419-425.
          doi: 10.1002/ccr3.1992pubmed: 30899463google scholar: lookup
        10. Beaumont KA, Mohana-Kumaran N, Haass NK. Modeling Melanoma In Vitro and In Vivo. Healthcare (Basel) 2013 Dec 23;2(1):27-46.
          doi: 10.3390/healthcare2010027pubmed: 27429258google scholar: lookup
        11. Metcalfe LV, O'Brien PJ, Papakonstantinou S, Cahalan SD, McAllister H, Duggan VE. Malignant melanoma in a grey horse: case presentation and review of equine melanoma treatment options. Ir Vet J 2013 Nov 6;66(1):22.
          doi: 10.1186/2046-0481-66-22pubmed: 24196087google scholar: lookup
        12. Seltenhammer MH, Sundström E, Meisslitzer-Ruppitsch C, Cejka P, Kosiuk J, Neumüller J, Almeder M, Majdic O, Steinberger P, Losert UM, Stöckl J, Andersson L, Sölkner J, Vetterlein M, Golovko A. Establishment and characterization of a primary and a metastatic melanoma cell line from Grey horses. In Vitro Cell Dev Biol Anim 2014 Jan;50(1):56-65.
          doi: 10.1007/s11626-013-9678-1pubmed: 23982913google scholar: lookup
        13. Fernandez AA, Paniker L, Garcia R, Mitchell DL. Recent advances in sunlight-induced carcinogenesis using the Xiphophorus melanoma model. Comp Biochem Physiol C Toxicol Pharmacol 2012 Jan;155(1):64-70.
          doi: 10.1016/j.cbpc.2011.03.007pubmed: 21457786google scholar: lookup
        Subscribe to our newsletter
        Join 99,357 horse owners like you who receive our email updates on horse health and nutrition.