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Equine veterinary journal2002; 34(2); 156-163; doi: 10.2746/042516402776767204

The use of magnetic motor evoked potentials in horses with cervical spinal cord disease.

Abstract: The aim of this study was to investigate the use of magnetic motor evoked potentials as an ancillary diagnostic test in horses with cervical cord lesions. Transcranial magnetic stimulation was performed in 12 ataxic horses and the results of the evoked responses were compared to those found in normal horses. The latency and peak-to-peak amplitude of the potentials in the 12 ataxic horses were significantly different from those measured in normal horses. The configuration of the abnormal potentials was also polyphasic. Normalisation of the evoked potentials occurred in none of the horses, presented after a period of clinical improvement. These findings demonstrate that the technique is also able to detect lesions in horses with subtle clinical signs of incoordination. Magnetic transcranial stimulation is a valuable ancillary test to assess the integrity of the motor tracts. The technique is painless and safe and shows good sensitivity to detect lesions along the descending motor pathways.
Publication Date: 2002-03-21 PubMed ID: 11902758DOI: 10.2746/042516402776767204Google Scholar: Lookup
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  • Comparative Study
  • Journal Article

Summary

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This study investigates if using magnetic motor evoked potentials are helpful in diagnosing horses with spinal cord lesions in their neck. Tests performed on 12 horses with ataxia showed significantly different results than in healthy horses, suggesting that this is a useful diagnostic technique.

Objective of the Study

  • The primary goal of this research was to explore the effectiveness of using magnetic motor evoked potentials as an additional diagnostic method in horses suffering from cervical spinal cord lesions.

Methodology

  • The researchers used transcranial magnetic stimulation on 12 horses that showed signs of ataxia, a condition marked by a lack of voluntary coordination of muscle movements.
  • The responses evoked by this stimulation were carefully studied and compared with responses from normal horses.

Key Findings

  • In the 12 ataxic horses, the latency (delay before the start of the response) and peak-to-peak amplitude (the max height of the wave indicating electrical activity) of the potentials were significantly different from the ones measured in normal horses.
  • The abnormal potentials also displayed a polyphasic configuration, meaning they appeared in multiple phases or parts, unlike the usual response.
  • Interestingly, none of the horses tested showed a return to normal evoked potentials even after a period of clinical improvement.
  • The technique was also found to be successful in identifying lesions in horses with subtle signs of incoordination, reinforcing its diagnostic capability.

Conclusions

  • The study concluded that magnetic transcranial stimulation is a valuable additional test for assessing the integrity of the motor tracts in horses.
  • This method is not only safe and painless but also exhibits high sensitivity towards detecting any lesions along the descending motor pathways in horses.

Cite This Article

APA
Nollet H, Deprez P, Van Ham L, Verschooten F, Vanderstraeten G. (2002). The use of magnetic motor evoked potentials in horses with cervical spinal cord disease. Equine Vet J, 34(2), 156-163. https://doi.org/10.2746/042516402776767204

Publication

ISSN: 0425-1644
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 34
Issue: 2
Pages: 156-163

Researcher Affiliations

Nollet, H
  • Department of Internal Medicine and Clinical Biology of Large Animals, Faculty of Veterinary Medicine, University of Ghent, Belgium.
Deprez, P
    Van Ham, L
      Verschooten, F
        Vanderstraeten, G

          MeSH Terms

          • Animals
          • Ataxia / diagnosis
          • Ataxia / physiopathology
          • Ataxia / veterinary
          • Electric Stimulation
          • Evoked Potentials, Motor / physiology
          • Female
          • Horse Diseases / diagnosis
          • Horse Diseases / physiopathology
          • Horses
          • Male
          • Reference Values
          • Spinal Cord Diseases / diagnosis
          • Spinal Cord Diseases / physiopathology
          • Spinal Cord Diseases / veterinary

          Citations

          This article has been cited 9 times.
          1. Journée SL, Journée HL, Berends HI, Reed SM, Bergmann W, de Bruijn CM, Delesalle CJG. Trapezius Motor Evoked Potentials From Transcranial Electrical Stimulation and Transcranial Magnetic Stimulation: Reference Data, Characteristic Differences and Intradural Motor Velocities in Horses.. Front Neurosci 2022;16:851463.
            doi: 10.3389/fnins.2022.851463pubmed: 35573305google scholar: lookup
          2. Journée SL, Journée HL, Berends HI, Reed SM, de Bruijn CM, Delesalle CJG. Comparison of Muscle MEPs From Transcranial Magnetic and Electrical Stimulation and Appearance of Reflexes in Horses.. Front Neurosci 2020;14:570372.
            doi: 10.3389/fnins.2020.570372pubmed: 33122992google scholar: lookup
          3. Journée SL, Journée HL, Reed SM, Berends HI, de Bruijn CM, Delesalle CJG. Extramuscular Recording of Spontaneous EMG Activity and Transcranial Electrical Elicited Motor Potentials in Horses: Characteristics of Different Subcutaneous and Surface Electrode Types and Practical Guidelines.. Front Neurosci 2020;14:652.
            doi: 10.3389/fnins.2020.00652pubmed: 32765207google scholar: lookup
          4. Rijckaert J, Raes E, Buczinski S, Dumoulin M, Deprez P, Van Ham L, van Loon G, Pardon B. Accuracy of transcranial magnetic stimulation and a Bayesian latent class model for diagnosis of spinal cord dysfunction in horses.. J Vet Intern Med 2020 Mar;34(2):964-971.
            doi: 10.1111/jvim.15699pubmed: 32030834google scholar: lookup
          5. Rijckaert J, Pardon B, Saey V, Raes E, Van Ham L, Ducatelle R, van Loon G, Deprez P. Determination of magnetic motor evoked potential latency time cutoff values for detection of spinal cord dysfunction in horses.. J Vet Intern Med 2019 Sep;33(5):2312-2318.
            doi: 10.1111/jvim.15576pubmed: 31490026google scholar: lookup
          6. Rijckaert J, Pardon B, Van Ham L, Joosten P, van Loon G, Deprez P. Magnetic motor evoked potentials of cervical muscles in horses.. BMC Vet Res 2018 Sep 24;14(1):290.
            doi: 10.1186/s12917-018-1620-zpubmed: 30249249google scholar: lookup
          7. Journée SL, Journée HL, de Bruijn CM, Delesalle CJG. Multipulse transcranial electrical stimulation (TES): normative data for motor evoked potentials in healthy horses.. BMC Vet Res 2018 Apr 3;14(1):121.
            doi: 10.1186/s12917-018-1447-7pubmed: 29615034google scholar: lookup
          8. Siedenburg JS, Wang-Leandro A, Amendt HL, Rohn K, Tipold A, Stein VM. Transcranial magnetic motor evoked potentials and magnetic resonance imaging findings in paraplegic dogs with recovery of motor function.. J Vet Intern Med 2018 May;32(3):1116-1125.
            doi: 10.1111/jvim.15058pubmed: 29566440google scholar: lookup
          9. Martin-Vaquero P, da Costa RC. Transcranial magnetic motor evoked potentials in Great Danes with and without clinical signs of cervical spondylomyelopathy: association with neurological findings and magnetic resonance imaging.. Vet J 2014 Sep;201(3):327-32.
            doi: 10.1016/j.tvjl.2014.05.035pubmed: 24929532google scholar: lookup