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Home / Equine Research Bank / Animals (Basel) / The Use of Platelet-Rich Plasma for Treatment of Tenodesmic ...
Animals : an open access journal from MDPI2021; 11(3); doi: 10.3390/ani11030793

The Use of Platelet-Rich Plasma for Treatment of Tenodesmic Lesions in Horses: A Systematic Review and Meta-Analysis of Clinical and Experimental Data.

Abstract: The use of platelet-rich plasma (PRP) to enhance tenodesmic lesion healing has been questioned over the years. The aim of this study was to evaluate current literature to establish the effectiveness of PRP for treating tenodesmic lesions through a systematic review, in accordance with the PRISMA guidelines, and a meta-analysis. Studies comparing PRP with placebo or other treatments for horses with tenodesmic injuries or evaluated PRP effect on tendon and ligament explants were included. Outcomes were clinical, ultrasound, histologic, molecular evaluation, and adverse effects. Two authors independently extracted data and assessed each study's risk of bias. Treatment effects were evaluated using risk ratios for dichotomous data, together with 95% CI. Data were pooled using the random-effects model. The quality of the evidence for each outcome was assessed using GRADE criteria. Twenty-four trials met inclusion criteria for systematic review, while fifteen studies were included in the meta-analysis. Results showed no significant differences in the outcomes between PRP and control groups. Finally, there is no definitive evidence that PRP enhances tendons and ligaments healing. Therefore, there is a need for more controlled trials to draw a firmer conclusion about the efficacy of PRP as a treatment for tenodesmic lesions in the horse.
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Publication Date: 2021-03-12 PubMed ID: 33809227PubMed Central: PMC7998797DOI: 10.3390/ani11030793Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article focuses on evaluating the effectiveness of platelet-rich plasma (PRP) treatment for healing tenodesmic lesions in horses, by conducting a systematic review and meta-analysis of available literature and data. The results indicate no significant differences between outcomes of PRP-treated cases and control groups, hence it concludes that there is no conclusive evidence supporting PRP’s effect on tendon and ligament healing in horses.

Selection of Studies for Review

  • The studies chosen for review were those that compared PRP treatment with either a placebo or other treatments for tenodesmic injuries in horses, or those that evaluated the effect of PRP on tendon and ligament explants.
  • The outcomes from these studies were assessed based on clinical results, ultrasound findings, histologic evaluations, molecular evaluations, and observed adverse effects.

Data Extraction and Assessment

  • Two authors independently extracted the relevant data from the studies and assessed each study for potential bias.
  • The treatment effects were evaluated using risk ratios for dichotomous data, assessed along with a 95% confidence interval.
  • The data extracted from these studies were pooled using the random effects model.

Quality of Evidence

  • The GRADE criteria was used to assess the quality of evidence for each outcome in the studies reviewed.

Results and Conclusion

  • Out of twenty four trials that met the inclusion criteria for the systematic review, fifteen were included in the meta-analysis.
  • The results showed no significant differences in the outcomes between the PRP treated groups and control groups.
  • Based on the findings, the authors concluded that there isn’t definitive evidence to confirm that PRP enhances the healing of tendons and ligaments.
  • The authors recommend that more controlled trials are needed in order to arrive at a more conclusive opinion about the efficacy of PRP as a treatment for tenodesmic lesions in horses.

Cite This Article

APA
Montano C, Auletta L, Greco A, Costanza D, Coluccia P, Del Prete C, Meomartino L, Pasolini MP. (2021). The Use of Platelet-Rich Plasma for Treatment of Tenodesmic Lesions in Horses: A Systematic Review and Meta-Analysis of Clinical and Experimental Data. Animals (Basel), 11(3). https://doi.org/10.3390/ani11030793

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 11
Issue: 3

Researcher Affiliations

Montano, Chiara
  • Veterinary Teaching Hospital, School of Veterinary Medicine, University of Córdoba, 14004 Córdoba, Spain.
Auletta, Luigi
  • Institute of Biostructure and Bioimaging, National Research Council (IBB CNR), Via T. De Amicis 95, 80145 Napoli, Italy.
Greco, Adelaide
  • Interdepartmental Centre of Veterinary Radiology, University of Napoli "Federico II", Via Federico Delpino 1, 80137 Napoli, Italy.
Costanza, Dario
  • Interdepartmental Centre of Veterinary Radiology, University of Napoli "Federico II", Via Federico Delpino 1, 80137 Napoli, Italy.
Coluccia, Pierpaolo
  • Interdepartmental Centre of Veterinary Radiology, University of Napoli "Federico II", Via Federico Delpino 1, 80137 Napoli, Italy.
Del Prete, Chiara
  • Department of Veterinary Medicine and Animal Production, University of Napoli "Federico II", Via Federico Delpino 1, 80137 Napoli, Italy.
Meomartino, Leonardo
  • Interdepartmental Centre of Veterinary Radiology, University of Napoli "Federico II", Via Federico Delpino 1, 80137 Napoli, Italy.
Pasolini, Maria Pia
  • Department of Veterinary Medicine and Animal Production, University of Napoli "Federico II", Via Federico Delpino 1, 80137 Napoli, Italy.

Conflict of Interest Statement

The authors declare no conflict of interest.

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Citations

This article has been cited 8 times.
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