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Home / Equine Research Bank / Vet Res Commun / The variability and repeatability of indices derived from th...
Veterinary research communications2001; 25(5); 401-412; doi: 10.1023/a:1010698811033

The variability and repeatability of indices derived from the single-breath diagram for CO2 in horses with chronic obstructive pulmonary disease and the effect of lobelin hydrochloride on these indices.

Abstract: Several indices of ventilatory heterogeneity can be identified from the volumetric capnogram and its graphic presentation, the single-breath diagram for CO2 (SBD-CO2). Physiologically based indices of pulmonary function (VTE, VCO2, FACO2, VDBohr% VDBohr%, VD/VTE, A1/A2) were calculated for healthy horses (group I, n = 5) and for horses with subclinical (group II, n = 7) or clinically manifest chronic obstructive pulmonary disease (COPD) (group III, n = 8) during tidal breathing and after medication with lobelin hydrochloride (Lobelin). We investigated the variability and repeatability of the lung function indices in healthy horses and in those with COPD both during tidal breathing and after administration of Lobelin, a centrally acting respiratory stimulant. In particular, we were interested in whether the discriminating ability of SBD-CO2-derived lung function indices would be increased between different patient groups after administration of Lobelin compared to those for the resting values. Of the indices studied, VTE, FACO, VDBohr% and A1/A2 appeared to be those with good to excellent repeatability in discriminating healthy horses from those with COPD. Stimulating respiration with Lobelin gave no advantage in the repeatability of the lung function indices or in differentiating between horses with different degrees of COPD.
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Publication Date: 2001-07-27 PubMed ID: 11469511DOI: 10.1023/a:1010698811033Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research explored the variability and repeatability of several indices related to horses’ pulmonary function, particularly those with Chronic Obstructive Pulmonary Disease (COPD). The impact of a specific medication, lobelin hydrochloride, on these indices was also examined. Results showed good to excellent repeatability in differentiating healthy horses from those with COPD for certain indices, with no significant enhancement noted through the introduction of lobelin hydrochloride.

Methods and Participant Groups

  • The researchers defined three groups of horses for their study: healthy (group I), those with subclinical COPD (group II), and those with clinically manifest COPD (groups III).
  • They calculated a variety of indices predominantly related to lung function and ventilation heterogeneity, utilizing a graphical presentation known as the single-breath diagram for CO2 (SBD-CO2).
  • The study also included evaluation of the indices following administration of the medication lobelin hydrochloride, a respiratory stimulant.

Variability and Repeatability of Indices

  • The main focus of the study was the degree of variability and repeatability of these lung function indices in both healthy horses and those with COPD, both under normal circumstances and following the administration of Lobelin.
  • Specially, the researchers were interested in the potential for enhanced discrimination ability of the SBD-CO2-derived lung function indices in differentiating patient groups post Lobelin administration, as compared to resting values.

Results and Conclusion

  • Of the various indices studied, VTE, FACO, VDBohr%, and A1/A2 were identified as having good to excellent repeatability in differentiating between healthy horses and those with COPD.
  • The introduction of Lobelin showed no significant advantage in enhancing the repeatability of these lung function indices, nor in further distinguishing between horses with different degrees of COPD.
  • Overall, the study concluded that while certain indices proved reliable in identifying COPD in horses, the use of Lobelin as a respiratory stimulant did not provide additional benefits in this context.

Cite This Article

APA
Herholz C, Straub R, Busato A. (2001). The variability and repeatability of indices derived from the single-breath diagram for CO2 in horses with chronic obstructive pulmonary disease and the effect of lobelin hydrochloride on these indices. Vet Res Commun, 25(5), 401-412. https://doi.org/10.1023/a:1010698811033

Publication

Veterinary research communications
ISSN: 0165-7380
NlmUniqueID: 8100520
Country: Switzerland
Language: English
Volume: 25
Issue: 5
Pages: 401-412

Researcher Affiliations

Herholz, C
  • Department of Equine Internal Medicine, Faculty of Veterinary Medicine, University of Berne, Switzerland.
Straub, R
    Busato, A

      MeSH Terms

      • Animals
      • Carbon Dioxide / metabolism
      • Female
      • Horse Diseases / drug therapy
      • Horse Diseases / physiopathology
      • Horses
      • Lobeline / administration & dosage
      • Lobeline / pharmacology
      • Male
      • Partial Pressure
      • Pulmonary Disease, Chronic Obstructive / drug therapy
      • Pulmonary Disease, Chronic Obstructive / physiopathology
      • Pulmonary Disease, Chronic Obstructive / veterinary
      • Respiratory Function Tests / veterinary
      • Respiratory System Agents / administration & dosage
      • Respiratory System Agents / pharmacology

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      Citations

      This article has been cited 2 times.
      1. Koo H, Ryu SH, Ahn HJ, Jung WK, Park YK, Kwon NH, Kim SH, Kim JM, Yoo BW, Choi SI, Davis WC, Park YH. Immunostimulatory effects of the anionic alkali mineral complex Barodon on equine lymphocytes. Clin Vaccine Immunol 2006 Nov;13(11):1255-66.
        doi: 10.1128/CVI.00150-06pubmed: 16943344google scholar: lookup
      2. Herholz C, Straub R, Lüthi S, Imhof A, Busato A. Differences in pulmonary functional indices derived from the single-breath diagram for CO2 (SBD-CO2) in horses related to age, sex and usage. Vet Res Commun 2002 Aug;26(6):467-78.
        doi: 10.1023/a:1020542525785pubmed: 12241100google scholar: lookup
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