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Home / Equine Research Bank / ISRN Vet Sci / Thiolated carboxymethyl-hyaluronic-Acid-based biomaterials e...
ISRN veterinary science2012; 2011; 851593; doi: 10.5402/2011/851593

Thiolated carboxymethyl-hyaluronic-Acid-based biomaterials enhance wound healing in rats, dogs, and horses.

Abstract: The progression of wound healing is a complicated but well-known process involving many factors, yet there are few products on the market that enhance and accelerate wound healing. This is particularly problematic in veterinary medicine where multiple species must be treated and large animals heal slower, oftentimes with complicating factors such as the development of exuberant granulation tissue. In this study a crosslinked-hyaluronic-acid (HA-) based biomaterial was used to treat wounds on multiple species: rats, dogs, and horses. The base molecule, thiolated carboxymethyl HA, was first found to increase keratinocyte proliferation in vitro. Crosslinked gels and films were then both found to enhance the rate of wound healing in rats and resulted in thicker epidermis than untreated controls. Crosslinked films were used to treat wounds on forelimbs of dogs and horses. Although wounds healed slower compared to rats, the films again enhanced wound healing compared to untreated controls, both in terms of wound closure and quality of tissue. This study indicates that these crosslinked HA-based biomaterials enhance wound healing across multiple species and therefore may prove particularly useful in veterinary medicine. Reduced wound closure times and better quality of healed tissue would decrease risk of infection and pain associated with open wounds.
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Publication Date: 2012-01-11 PubMed ID: 23738117PubMed Central: PMC3658841DOI: 10.5402/2011/851593Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article explores how thiolated carboxymethyl-hyaluronic-Acid-based biomaterials can accelerate wound healing in different animal species including rats, dogs, and horses.

Study Overview and Methodology

  • The study was primarily aimed at finding viable solutions to speed up the wound healing process in animals, which is problematic due to species variation and inherently slower healing in larger animals.
  • The approach was to use a specific type of biomaterial based on crosslinked-hyaluronic-acid (HA), known as thiolated carboxymethyl HA, to treat wounds on multiple species including rats, dogs, and horses.
  • Initially, the researchers tested how the base molecule, thiolated carboxymethyl HA, would affect keratinocyte proliferation (cell growth) under lab conditions.
  • After confirming a positive effect on keratinocyte proliferation, the researchers then used crosslinked gels and films made of this biomaterial to treat wounds on rats, dogs, and horses—evaluating the wound healing rate and the quality of tissue in the healed area.

Findings and Conclusion

  • The results demonstrated that the crosslinked HA-based biomaterials enhanced the rate of wound healing in all studied species. The treated wounds not only healed faster but also resulted in a superior quality of healed tissue compared to untreated wounds.
  • Despite the inherent slower wound healing rate in larger animals such as dogs and horses compared to rats, the biomaterial films still significantly improved the wound healing process.
  • Therefore, the study concluded that these types of biomaterials could potentially be very beneficial in veterinary medicine.
  • By reducing wound closure times and improving the quality of healed tissue, the risk of infection and pain associated with open wounds could be considerably decreased.

Cite This Article

APA
Yang G, Prestwich GD, Mann BK. (2012). Thiolated carboxymethyl-hyaluronic-Acid-based biomaterials enhance wound healing in rats, dogs, and horses. ISRN Vet Sci, 2011, 851593. https://doi.org/10.5402/2011/851593

Publication

ISRN veterinary science
ISSN: 2090-4452
NlmUniqueID: 101568322
Country: Egypt
Language: English
Volume: 2011
Pages: 851593

Researcher Affiliations

Yang, Guanghui
  • Department of Medicinal Chemistry and Center for Therapeutic Biomaterials, University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, UT 84108, USA.
Prestwich, Glenn D
    Mann, Brenda K

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      Citations

      This article has been cited 9 times.
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