Three equine cases of mixed hepatoblastoma with teratoid features.
Abstract: Hepatoblastoma was diagnosed in 3 Thoroughbreds at the University of Kentucky Livestock Disease Diagnostic Center (LDDC) since 1997. Case #1 involved a fetus with a well-demarcated, multilobulated, solitary mass that extended from the left liver lobe. Case #2 was observed in a neonate with a primary hepatic mass and multiple metastases in the skin, brain, meninges, and stylohyoid bone. Case #3 was a solitary hepatic mass incidentally discovered in a neonate at necropsy. Microscopically, the masses were similarly composed of sheets and cords of fetal and embryonal epithelial cells that frequently formed sinusoid-like structures. Intermixed with the neoplastic epithelial cells were variable amounts of hemorrhage, necrosis, osteoid, and bone. Immunohistochemically, the epithelial cells stained variably positive for alpha- fetoprotein, frequently positive for vimentin, and occasionally positive for cytokeratin. All 3 cases were diagnosed as mixed hepatoblastoma with teratoid features.
Publication Date: 2007-02-24 PubMed ID: 17317799DOI: 10.1354/vp.44-2-211Google Scholar: Lookup
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Summary
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This research studied three cases of mixed hepatoblastoma with teratoid features in thoroughbred horses, diagnosed at the University of Kentucky Livestock Disease Diagnostic Center. The study provides insights into the features and diagnosis of these rare tumors.
Introduction and Methodology
- The paper is a case study of three Thoroughbred horses diagnosed with hepatoblastoma at the University of Kentucky Livestock Disease Diagnostic Center (LDDC) since 1997. Hepatoblastoma is a rare form of liver cancer typically found in infants and children.
- The researchers conducted a macroscopic and microscopic examination of the identified tumors and ran immunohistochemical tests to study the staining pattern of the tumor cells.
Case Studies
- Case one was a horse fetus which had a well-defined, multi-lobulated solitary mass extending from the left liver lobe.
- Case two was a neonate with a primary hepatic (liver) mass that had metastasized to other regions including the skin, brain, meninges, and stylohyoid bone.
- Case three was also a neonate, in whom a solitary hepatic mass was found incidentally during autopsy.
Microscopic Examination and Immunohistochemistry
- Upon observation, the tumors were found to consist of sheets and cords of fetal and embryonal epithelial cells, often forming sinusoid-like structures.
- The tumors also contained different amounts of hemorrhage, necrosis (dead cells or tissues), osteoid (immature bone tissue), and bone.
- Immunohistochemical study revealed varied staining patterns. Epithelial cells showed variable positivity for alpha-fetoprotein, frequent positivity for vimentin (a kind of protein), and occasional positivity for cytokeratin (a family of proteins present in the intermediate filaments of vertebrate epithelial cells).
Conclusion
- All three cases were diagnosed as mixed hepatoblastoma with teratoid features (a rare type of tumor that contains various types of tissues, signifying the abnormal differentiation of cells).
- This study provides not only insights into diagnosis but also the varied manifestations of this rare tumor in equine cases.
Cite This Article
APA
Loynachan AT, Bolin DC, Hong CB, Poonacha KB.
(2007).
Three equine cases of mixed hepatoblastoma with teratoid features.
Vet Pathol, 44(2), 211-214.
https://doi.org/10.1354/vp.44-2-211 Publication
Researcher Affiliations
- Liverstock Disease Diagnostic Center, University of Kentucky, PO Box 14125, Lexington, KY 40512, USA. alan.loynachan@uky.edu
MeSH Terms
- Animals
- Animals, Newborn
- Fatal Outcome
- Fetus
- Hepatoblastoma / pathology
- Hepatoblastoma / veterinary
- Horse Diseases / pathology
- Horses
- Immunohistochemistry / veterinary
- Liver Neoplasms / pathology
- Liver Neoplasms / veterinary
- Teratoma / pathology
- Teratoma / veterinary
Citations
This article has been cited 3 times.- Drozdzewska K, Gehlen H. Markers for internal neoplasia in the horse. Vet Med Sci 2023 Jan;9(1):132-143.
- Sergi CM, Rojas-Vasquez M, Noga M, Dicken B. 'Teratoid' Hepatoblastoma: An Intriguing Variant of Mixed Epithelial-Mesenchymal Hepatoblastoma. Children (Basel) 2022 Apr 15;9(4).
- Tirosh-Levy S, Perl S, Valentine BA, Kelmer G. Erythrocytosis and fatigue fractures associated with hepatoblastoma in a 3-year-old gelding. J S Afr Vet Assoc 2019 Mar 28;90(0):e1-e5.
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