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Home / Equine Research Bank / Vet Sci / Topical Use of Sucralfate in Cutaneous Wound Management: A N...
Veterinary sciences2025; 12(8); 756; doi: 10.3390/vetsci12080756

Topical Use of Sucralfate in Cutaneous Wound Management: A Narrative Review with a Veterinary Perspective.

Abstract: Wound management is a fundamental skill for veterinarians, requiring a systematic approach to wound care and a deep understanding of the biological principles underlying healing. Sucralfate, widely known as a mucoprotective agent for gastroduodenal ulcers, has recently shown promising topical effects in human skin lesions by binding and protecting growth factors from proteolytic degradation, thereby enhancing their local availability. This action promotes angiogenesis, chemotaxis and cell proliferation, while reducing oxidative stress and exerting bacteriostatic and bactericidal effects against common pathogens. However, the veterinary-specific literature on topical sucralfate is extremely limited, with most available data derived from experimental studies in rodent and porcine models, rather than clinical studies in common veterinary species. Nonetheless, these preliminary studies suggest a potential role for sucralfate in accelerating the healing process through improved collagen synthesis, neovascularization and fibroblast activity. Given the species-specific challenges in veterinary wound healing-especially in horses and cats, prone to delayed healing and exuberant granulation tissue-sucralfate represents a promising, cost-effective and safe candidate for clinical use. This narrative review synthetizes current evidence on sucralfate's mechanisms and therapeutic benefits across human and veterinary contexts, highlighting the need for controlled, multidisciplinary veterinary studies. Validating sucralfate's efficacy in clinical settings could enable the growing owner demand for advanced care to be satisfied, shorten recovery times, reduce complications and improve animal welfare.
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Publication Date: 2025-08-13 PubMed ID: 40872708PubMed Central: PMC12390033DOI: 10.3390/vetsci12080756Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

Topical sucralfate, traditionally used for gastroduodenal ulcers, shows promising potential in enhancing wound healing in veterinary medicine by promoting tissue repair mechanisms and offering antimicrobial effects, although clinical evidence in common veterinary species is currently limited.

Background and Importance of Wound Management in Veterinary Medicine

  • Wound management is a crucial skill for veterinarians, necessitating a structured approach to care and a strong grasp of wound healing biology.
  • Healing processes in animals, especially species like horses and cats, can face challenges such as delayed healing and excessive granulation tissue formation.
  • Improving wound care practices can reduce recovery time, complications, and enhance overall animal welfare.

What is Sucralfate and Its Conventional Use

  • Sucralfate is primarily known as a mucoprotective agent used for treating gastroduodenal ulcers by forming a protective barrier over lesions.
  • Its traditional application is systemic or oral, focused on gastrointestinal mucosa protection.

Emerging Evidence for Topical Sucralfate in Skin Wound Healing

  • Recent studies indicate sucralfate can be topically applied to skin wounds to bind and protect growth factors from degradation.
  • This protection enhances the local availability of growth factors, which are key for:
    • Angiogenesis (formation of new blood vessels)
    • Chemotaxis (attraction of immune and repair cells to the wound site)
    • Cell proliferation (growth of skin cells necessary for repair)
  • Sucralfate also helps reduce oxidative stress and has bacteriostatic (inhibiting bacterial growth) and bactericidal (killing bacteria) effects against common wound pathogens.

Veterinary-Specific Context and Challenges

  • There is a lack of extensive clinical data on topical sucralfate use in veterinary medicine, with most evidence coming from rodent and pig models.
  • Despite limited data, initial studies show promise in:
    • Boosting collagen synthesis, essential for wound strength and structure
    • Enhancing neovascularization, crucial for tissue oxygenation and nutrient supply
    • Stimulating fibroblast activity, cells that generate connective tissue to repair wounds
  • These effects suggest sucralfate could accelerate wound healing in veterinary patients effectively.

Potential Benefits and Practical Considerations

  • Sucralfate is cost-effective and has a good safety profile, making it an attractive option for veterinary wound care.
  • Its potential application is particularly important for species that often suffer from slower healing or complicating wound factors, like horses and cats.
  • Use of sucralfate might help meet increasing owner demand for advanced wound treatment options.

Need for Further Research

  • The review highlights a critical need for controlled, multidisciplinary clinical trials in common veterinary species to validate sucralfate’s efficacy and safety.
  • Such research would help integrate sucralfate into evidence-based veterinary wound management protocols.
  • Ultimately, clinically validated topical sucralfate could improve treatment outcomes, reduce healing time, and decrease wound-related complications.

Cite This Article

APA
Accorroni L, Dini F, Pilati N, Marchegiani A, Bazzano M, Spaterna A, Laus F. (2025). Topical Use of Sucralfate in Cutaneous Wound Management: A Narrative Review with a Veterinary Perspective. Vet Sci, 12(8), 756. https://doi.org/10.3390/vetsci12080756

Publication

Veterinary sciences
ISSN: 2306-7381
NlmUniqueID: 101680127
Country: Switzerland
Language: English
Volume: 12
Issue: 8
PII: 756

Researcher Affiliations

Accorroni, Lucrezia
  • School of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93/95, 62024 Matelica, MC, Italy.
Dini, Fabrizio
  • School of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93/95, 62024 Matelica, MC, Italy.
Pilati, Nicola
  • School of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93/95, 62024 Matelica, MC, Italy.
Marchegiani, Andrea
  • School of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93/95, 62024 Matelica, MC, Italy.
Bazzano, Marilena
  • School of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93/95, 62024 Matelica, MC, Italy.
Spaterna, Andrea
  • School of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93/95, 62024 Matelica, MC, Italy.
Laus, Fulvio
  • School of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93/95, 62024 Matelica, MC, Italy.

Conflict of Interest Statement

The authors declare no conflicts of interest.

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