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Home / Equine Research Bank / Vet J / Towards personalized medicine for the treatment of equine as...
Veterinary journal (London, England : 1997)2024; 106125; doi: 10.1016/j.tvjl.2024.106125

Towards personalized medicine for the treatment of equine asthma.

Abstract: Although horses with asthma share similar clinical signs, the heterogeneity of the disease in terms of severity, triggering factors, inflammatory profile, and pathological features has hindered our ability to define biologically distinct subgroups. The recognition of phenotypes and endotypes could enable the development of precision medicine, including personalized, targeted therapy, to benefit affected horses. While in its infancy in horses, this review outlines the phenotypes of equine asthma and discusses how knowledge gained from targeted therapy in human medicine can be applied to evaluate the potential opportunities for personalized medicine in equine asthma and to suggest avenues for research to advance this emerging field.
Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.
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Publication Date: 2024-05-02 PubMed ID: 38704018DOI: 10.1016/j.tvjl.2024.106125Google Scholar: Lookup
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Summary

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The research article discusses the complexities and heterogeneity of equine asthma and explores the potential for personalized medicine solutions. Specifically, it examines how insights from human asthma treatment could help develop targeted therapies for horses with this condition.

Complexities of Equine Asthma

  • Asthma in horses, like in humans, is a heterogeneous disease. This means it varies greatly in terms of severity, triggering factors, inflammatory profile, and pathological features among individual horses.
  • This heterogeneity has created challenges in identifying biologically distinct subgroups of the disease, which has in turn hampered the development of targeted treatments.

    • Recognizing Phenotypes and Endotypes

  • Despite the challenges, the paper emphasizes the importance of recognizing different phenotypes and endotypes of equine asthma. A phenotype refers to observable traits, while an endotype refers to the underlying pathophysiological mechanisms of the disease.
  • This recognition could lead to the development of precision medicine — highly personalized, targeted treatment strategies for equine asthma.

    • Targeted Therapy in Human Medicine

  • The research article reviews the progress made in targeted therapy in human medicine, and how this knowledge could be applied to treating equine asthma.
  • By drawing parallels between the two, the researchers hope to illuminate potential opportunities for personalized medicine in the treatment of equine asthma.

    • Future Research Recommendations

  • The article concludes by suggesting future research pathways to further the development of targeted therapies for equine asthma.
  • Specifically, the authors propose investigating the biological markers of equine asthma, understanding the genetic basis of the disease, and conducting large, randomized controlled trials.
  • Through such research, the scientists hope to advance the field of personalizing medicine for treating equine asthma.

    • Cite This Article

    APA
    Leduc L, Leclère M, Lavoie JP. (2024). Towards personalized medicine for the treatment of equine asthma. Vet J, 106125. https://doi.org/10.1016/j.tvjl.2024.106125

    Publication

    Veterinary journal (London, England : 1997)
    ISSN: 1532-2971
    NlmUniqueID: 9706281
    Country: England
    Language: English
    Pages: 106125
    PII: S1090-0233(24)00064-9

    Researcher Affiliations

    Leduc, Laurence
    • Department of Clinical Sciences, Faculté de Médecine Vétérinaire, Université de Montréal, St-Hyacinthe, QC, J2S 2M2, Canada.
    Leclère, Mathilde
    • Department of Clinical Sciences, Faculté de Médecine Vétérinaire, Université de Montréal, St-Hyacinthe, QC, J2S 2M2, Canada.
    Lavoie, Jean-Pierre
    • Department of Clinical Sciences, Faculté de Médecine Vétérinaire, Université de Montréal, St-Hyacinthe, QC, J2S 2M2, Canada. Electronic address: pierre.lavoie@umontreal.ca.

    Citations

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