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Home / Equine Research Bank / Osteoarthritis Cartilage / Transection of vessels in epiphyseal cartilage canals leads ...
Osteoarthritis and cartilage2013; 21(5); 730-738; doi: 10.1016/j.joca.2013.02.005

Transection of vessels in epiphyseal cartilage canals leads to osteochondrosis and osteochondrosis dissecans in the femoro-patellar joint of foals; a potential model of juvenile osteochondritis dissecans.

Abstract: To transect blood vessels within epiphyseal cartilage canals and observe whether this resulted in ischaemic chondronecrosis, an associated focal delay in enchondral ossification [osteochondrosis (OC)] and pathological cartilage fracture [osteochondrosis dissecans (OCD)] in the distal femur of foals, with potential translational value to the pathogenesis of juvenile osteochondritis dissecans (JOCD) in children. Methods: Ten Norwegian Fjord Pony foals were operated at the age of 13-15 days. Two vessels supplying the epiphyseal growth cartilage of the lateral trochlear ridge of the left distal femur were transected in each foal. Follow-up examination was carried out from 1 to 49 days post-operatively and included plain radiography, macroscopic and histological examination. Results: Transection of blood vessels within epiphyseal cartilage canals resulted in necrosis of vessels and chondrocytes, i.e., ischaemic chondronecrosis, in foals. Areas of ischaemic chondronecrosis were associated with a focal delay in enchondral ossification (OC) in foals examined 21 days or more after transection, and pathological cartilage fracture (OCD) in one foal examined 42 days after transection. Conclusions: The ischaemic hypothesis for the pathogenesis of OC has been reproduced experimentally in foals. There are several similarities between OCD in animals and JOCD in children. It should be investigated whether JOCD also occurs due to a focal failure in the cartilage canal blood supply, followed by ischaemic chondronecrosis.
Copyright © 2013 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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Publication Date: 2013-02-18 PubMed ID: 23428601DOI: 10.1016/j.joca.2013.02.005Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research aimed to investigate the effects of interrupting the blood supply in cartilage canals on the development of osteochondrosis and osteochondrosis dissecans in the kneecap joint of young horses, potentially offering insights into juvenile osteochondritis dissecans in children.

Methods

  • The study was carried out using ten Norwegian Fjord Pony foals, selected for surgery when they were approximately two weeks old.
  • Two blood vessels that supplied the growth cartilage of a specific part (lateral trochlear ridge) of the femur were deliberately cut.
  • The changes were observed chronologically, using radiography, macroscopic and histological examination, from day 1 to day 49 post-surgery.

Results

  • The interruption of the blood supply within the canals of the horse’s growth cartilage resulted in the death of the vessels and cartilage cells, a condition known as ischaemic chondronecrosis.
  • A “focal delay in enchondral ossification”, also known as osteochondrosis (OC), was found in the areas affected by ischaemic chondronecrosis in foals examined 21 days or more after the blood vessels were cut.
  • In a foal examined 42 days post-operation, there was a pathological cartilage fracture, a condition referred to as osteochondrosis dissecans (OCD).

Conclusions

  • This research successfully replicated the theory that osteochondrosis (a disease affecting the growth of bones and cartilage in young horses) results from an interrupted blood supply leading to the death of cartilage cells.
  • However, researchers also noted similarities between OCD in foals and a similar condition in children known as juvenile osteochondritis dissecans (JOCD), suggesting further investigation to determine whether JOCD also occurs due to a disruption in the cartilage canal blood supply is necessary.

Cite This Article

APA
Olstad K, Hendrickson EH, Carlson CS, Ekman S, Dolvik NI. (2013). Transection of vessels in epiphyseal cartilage canals leads to osteochondrosis and osteochondrosis dissecans in the femoro-patellar joint of foals; a potential model of juvenile osteochondritis dissecans. Osteoarthritis Cartilage, 21(5), 730-738. https://doi.org/10.1016/j.joca.2013.02.005

Publication

Osteoarthritis and cartilage
ISSN: 1522-9653
NlmUniqueID: 9305697
Country: England
Language: English
Volume: 21
Issue: 5
Pages: 730-738
PII: S1063-4584(13)00046-0

Researcher Affiliations

Olstad, K
  • Norwegian School of Veterinary Science, Department of Companion Animal Clinical Sciences, Equine Section, Norway. kristin.olstad@nvh.no
Hendrickson, E H S
    Carlson, C S
      Ekman, S
        Dolvik, N I

          MeSH Terms

          • Animals
          • Blood Vessels / injuries
          • Chondrocytes / pathology
          • Disease Models, Animal
          • Female
          • Femur / blood supply
          • Growth Plate / blood supply
          • Horses
          • Ischemia / complications
          • Male
          • Necrosis / etiology
          • Osteochondritis Dissecans / etiology
          • Osteochondritis Dissecans / pathology
          • Osteochondrosis / etiology
          • Osteochondrosis / pathology

          Citations

          This article has been cited 29 times.
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