Treatment of equine glaucoma by transscleral neodymium:yttrium aluminum garnet laser cyclophotocoagulation: a retrospective study of 23 eyes of 16 horses.
Abstract: Contact neodymium:yttrium aluminum garnet (Nd:YAG) laser transscleral cyclophotocoagulation (TSCP) was performed on 23 eyes of 16 horses for treatment of glaucoma. The mean highest preoperative IOP was 51 +/- 17 mmHg. Follow-up evaluation was available for 19 eyes 1 day after surgery, 14 eyes from 1 to 2 weeks, 16 eyes from 4 to 6 weeks, 9 eyes from 12 to 16 weeks, and 10 eyes greater than 20 weeks after laser treatment. The mean intraocular pressure (IOP) the day following surgery was 34 +/- 13 mmHg. The mean IOP for each follow-up period was: one to two weeks postoperative, 23 +/- 9 mmHg; four to six weeks, 24 +/- 7 mmHg; 12-16 weeks, 28 +/- 10 mmHg; and >/= 20 weeks, 22 +/- 9 mmHg. IOP measurements were significantly different from pretreatment values for all follow-up intervals except for weeks 12-16 (P < 0.05). Treatment success was defined as maintenance of IOP < 30 mmHg. Treatment success was achieved in 93%, 88%, 78%, and 70% of the treated eyes at the 1-2 weeks, 4-6 weeks, 12-16 weeks, and the >/= 20 weeks re-evaluation, respectively. No significant difference was found between the number of eyes visual at presentation (52.2%) and visual at 20 weeks (60%). The most common laser complications were conjunctival hyperemia (21.7%) and corneal ulcers (13.0%). Results of this study indicate that Nd:YAG TSCP is an effective method of controlling IOP and preserving vision in horses with glaucoma. An effective Nd:YAG laser protocol for TSCP in the equine glaucomatous eye is a power setting of 11 W, duration of 0.4 s, applied 5 mm posterior to the limbus at 60 sites, resulting in a total energy dose of 264 J.
Publication Date: 2001-06-09 PubMed ID: 11397272DOI: 10.1046/j.1463-5224.1999.00083.xGoogle Scholar: Lookup
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Summary
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The research investigates the effectiveness of a laser-based treatment, neodymium:yttrium aluminum garnet (Nd:YAG) laser transscleral cyclophotocoagulation, in managing glaucoma in horses. Key results suggest that the procedure is efficient in controlling intraocular pressure and maintaining vision, with manageable side effects.
Research Methodology
- The researchers treated 23 eyes from 16 horses suffering from glaucoma using the contact Nd:YAG laser TSCP procedure.
- The preoperative intraocular pressure (IOP)– the pressure within the eye – was measured to have a mean highest value of 51 +/- 17 mmHg.
- Progressive follow-up examinations were conducted to assess the effectiveness of the treatment. These were carried out 1 day after surgery and then repeated after 1-2 weeks, 4-6 weeks, 12-16 weeks, and over 20 weeks of postoperative period.
Findings
- The average IOP significantly lowered at every follow-up interval, except between weeks 12 to 16, where it was not found to be statistically different from the pretreatment value.
- The treatment was considered successful if the IOP readings fell below 30 mmHg. Success rates were found to be 93% at 1-2 weeks, 88% at 4-6 weeks, 78% 12-16 weeks, and 70% after 20 weeks postoperative.
- There was no significant difference between the number of eyes that had vision before the treatment (52.2%) and those that were still visual after 20 weeks (60%), suggesting the treatment did not adversely impact vision in the long term.
- The most common complications recorded following the laser treatment were conjunctival hyperemia (reddening of the sclera due to increased blood flow) that was found in 21.7% of cases, and corneal ulcers reported in 13% of cases.
Implication of the Study
- The study provides support for the Nd:YAG TSCP as an effective treatment option for equine glaucoma. This laser surgical procedure shows promising results in both controlling elevated IOP and preserving vision in horses with the condition.
- An efficient protocol for this laser procedure suggests using a power setting of 11 W, with a duration of 0.4 s at 60 sites, ideally applied 5 mm behind the limbus, resulting in a total energy dose of 264 J.
Cite This Article
APA
Whigham HM, Brooks DE, Andrew SE, Gelatt KN, Strubbe DT, Biros DJ.
(2001).
Treatment of equine glaucoma by transscleral neodymium:yttrium aluminum garnet laser cyclophotocoagulation: a retrospective study of 23 eyes of 16 horses.
Vet Ophthalmol, 2(4), 243-250.
https://doi.org/10.1046/j.1463-5224.1999.00083.x Publication
Researcher Affiliations
- University of Florida, Veterinary Medical Teaching Hospital, Departments of Small and Large Animal Clinical Sciences, PO Box 100126, Gainesville, FL 32610, USA.
Citations
This article has been cited 2 times.- Gemensky-Metzler AJ, Wilkie DA, Weisbrode SE, Kuhn SE. The location of sites and effect of semiconductor diode trans-scleral cyclophotocoagulation on the buphthalmic equine globe. Vet Ophthalmol 2014 Jul;17 Suppl 1(0 0):107-16.
- Bouhenni RA, Dunmire J, Sewell A, Edward DP. Animal models of glaucoma. J Biomed Biotechnol 2012;2012:692609.
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