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Treatment of gastric lesions in horses with pectin-lecithin complex.
Abstract: This study compared the study of a pectin-lecithin complex (Pronutrin) on gastric ulcer healing during an 11 day period in 2 groups of 12 horses each. Twenty-four horses suffering from gastric lesions of differing severity were selected from a larger group of clinical cases on the basis of gastroscopic examination. Both gastric mucosal erosions as well as gastric ulcers were found in the 2 mucosal regions (pars nonglandularis and pars glandularis). The gastric mucosal lesions occurred predominantly in the pars nonglandularis in the vicinity of the margo plicatus. The 24 horses were divided equally into a treated group (Group A) and a control group (Group B). Twelve horses in Group A received Pronutrin, in a dose of 300 g/horse/day over a period of 10 days, whereas horses in Group B received no active substance. Gastroscopic examination was performed on Days 0 and 11. The degree of severity of the gastric erosions or gastric ulcers was evaluated independently in the 2 mucosal regions with the aid of a scoring system. Group A horses showed good acceptance of the product and no side effects were recorded. After the 10 day treatment phase, Group A showed a marked reduction in gastric mucosal lesions or disappearance of lesions, while untreated horses showed no change or, even, a deterioration on Day 11. Statistical calculation of efficacy revealed a highly significant reduction in gastric mucosal lesions in the pars nonglandularis and a significant reduction in gastric mucosal lesions in the pars glandularis in the treated horses. It would appear, however, that the treatment period of 10 days was too short, since the gastric mucosal lesions had often not completely healed in all horses. The results of this study in 24 horses with gastric lesions suggest that a pectin-lecithin complex can have a beneficial effect on the healing of gastric ulcers.
Publication Date: 2000-03-04 PubMed ID: 10696303DOI: 10.1111/j.2042-3306.1999.tb05178.xGoogle Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Clinical Trial
- Comparative Study
- Controlled Clinical Trial
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research article explores the effects of using a pectin-lecithin complex (Pronutrin) in treating gastric ulcers in horses. It concludes that Pronutrin significantly speeds up the healing of gastric mucosal lesions.
Purpose and Methodology
The study was designed to evaluate the impact of a pectin-lecithin complex on the healing of gastric ulcers in horses. This involved the selection of 24 horses suffering from mild to severe gastric lesions from a broader population. The selection was based on gastroscopic examinations. The horses presented with gastric mucosal erosions and ulcers in both the non-glandular (pars nonglandularis) and glandular (pars glandularis) sections of the stomach. More lesions were concentrated in the pars nonglandularis, especially near the margo plicatus.
Horses were then divided equally into two groups: a test group (Group A) and a control group (Group B). Those in Group A were administered 300 g/horse/day of Pronutrin for 10 days while Group B received no treatment. After which, a gastroscopic examination was done on Days 0 and 11 to assess the severity of the gastric erosions or ulcers.
Results and Findings
The treated horses in Group A showed a high tolerance for Pronutrin, with no recorded side effects. Furthermore, following the 10-day treatment period, Group A presented a considerable decrease or complete disappearance of gastric mucosal lesions, unlike the untreated group B horses who showed no change or even a deterioration in their condition.
Through statistical evaluation, the researchers found a highly significant reduction in gastric mucosal lesions in the non-glandular section and a noticeable reduction in the glandular segment of the stomach in treated horses. However, the study also suggested that the 10-day treatment period wasn’t sufficient, as not all treated horses completely healed from their gastric mucosal lesions.
Conclusion
The results from this small-scale study imply that a pectin-lecithin complex could indeed have a beneficial effect on the healing of gastric ulcers in horses. This generates a foundation for further larger and more comprehensive trials to validate the efficacy and safety of pectin-lecithin complex in ulcer treatment for horses and potentially other animals.
Cite This Article
APA
Venner M, Lauffs S, Deegen E.
(2000).
Treatment of gastric lesions in horses with pectin-lecithin complex.
Equine Vet J Suppl(29), 91-96.
https://doi.org/10.1111/j.2042-3306.1999.tb05178.x Publication
Researcher Affiliations
- Klinik fur Pferde, Tierärztliche Hochschule Hannover, Germany.
MeSH Terms
- Animals
- Anti-Ulcer Agents / therapeutic use
- Female
- Gastroscopy / veterinary
- Horse Diseases / drug therapy
- Horses
- Lectins / therapeutic use
- Male
- Pectins
- Phosphatidylcholines / therapeutic use
- Severity of Illness Index
- Stomach Ulcer / drug therapy
- Stomach Ulcer / veterinary
- Treatment Outcome
Citations
This article has been cited 7 times.- Irving J, Pineau V, Shultz S, Ter Woort F, Julien F, Lambey S, van Erck-Westergren E. Impact of Low-Starch Dietary Modifications on Faecal Microbiota Composition and Gastric Disease Scores in Performance Horses. Animals (Basel) 2025 Jun 28;15(13).
- Leleu C, Couroucé A. Effect of a blend of magnesium oxide on Equine Squamous Gastric Disease in young trotter horses under training. J Vet Sci 2023 Nov;24(6):e87.
- Vokes J, Lovett A, Sykes B. Equine Gastric Ulcer Syndrome: An Update on Current Knowledge. Animals (Basel) 2023 Apr 5;13(7).
- Hewetson M, Tallon R. Equine Squamous Gastric Disease: Prevalence, Impact and Management. Vet Med (Auckl) 2021;12:381-399.
- Sykes BW, Hewetson M, Hepburn RJ, Luthersson N, Tamzali Y. European College of Equine Internal Medicine Consensus Statement--Equine Gastric Ulcer Syndrome in Adult Horses. J Vet Intern Med 2015 Sep-Oct;29(5):1288-99.
- Woodward MC, Huff NK, Garza F Jr, Keowen ML, Kearney MT, Andrews FM. Effect of pectin, lecithin, and antacid feed supplements (Egusin®) on gastric ulcer scores, gastric fluid pH and blood gas values in horses. BMC Vet Res 2014;10 Suppl 1(Suppl 1):S4.
- Hellings IR, Larsen S. ImproWin® in the treatment of gastric ulceration of the squamous mucosa in trotting racehorses. Acta Vet Scand 2014 Mar 13;56(1):13.
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