Treatment of respiratory infections in horses with ceftiofur sodium.
Abstract: Ceftiohr sodium was evaluated as a therapy for respiratory
infections in horses. This cephalosporin antimicrobial was
administered intramuscularly every 24 h and at a dose of 2.2
mglkg (1.0 mgllb) of body weight. The efficacy of ceftiofur
sodium was compared with that of a positive control drug,
ampicillin sodium (recommended dose of 6.6 mg/kg [3 mg/lb],
given every 12 h). Both treatments were continued for 48 h
after clinical symptoms were no longer evident (maximum of
10 days). Fifty-five (55) horses with naturally acquired
respiratory infections were included in the study; 28 were
treated with ceftiofur and 27 with ampicillin. Clinical
improvement was recorded for 92.9% of the patients treated
with ceftiofur and 92.6% of the animals receiving ampicillin.
Both therapies reduced body temperatures to an afebrile level
after 2 days of treatment. Complete recoverylcure was noted
for 78.6% of the ceftiofur patients and 59.3% of the horses
treated with ampicillin. Supporting variables
(depressionlmalaise, respirationldyspnoea, nasal discharge)
were assessed and these also substantiated the effectiveness of
the treatments. Both antibiotics were well tolerated. Neither
pain nor swelling were noted at the ceftiofur injection site(s).
None of the animals developed diarrhoea. Data from this
study indicated that ceftiofur sodium is an effective and safe
treatment for respiratory infections in horses.
Publication Date: 1993-05-01 PubMed ID: 8508746
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Summary
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This research investigates the efficacy of Ceftiofur sodium, a cephalosporin antimicrobial, in treating respiratory infections in horses, comparing results with the commonly used drug, Ampicillin sodium. The study finds that Ceftiofur sodium is a safe and effective treatment, outperforming Ampicillin in rates of complete recovery.
Objective of the Study
- The objective of this study was to evaluate the effectiveness of Ceftiofur sodium as a treatment for horses with respiratory infections and to compare its effectiveness with that of Ampicillin sodium, a commonly used drug for such infections.
Methodology
- Fifty-five horses with naturally acquired respiratory infections were included in this clinical trial. 28 of them were treated with Ceftiofur sodium, while the remaining 27 were treated with Ampicillin sodium.
- The Ceftiofur sodium was administered by intramuscular injection every 24 hours at a dosage of 2.2 mg/kg of the horse’s body weight. Ampicillin sodium was administered at a dose of 6.6 mg/kg, twice daily.
- The treatment was continued for 48 hours after no clinical symptoms were evident, up to a maximum of 10 days.
Results of the Study
- The study found that clinical improvement was seen in 92.9% of the Ceftiofur-treated group and in 92.6% of the Ampicillin-treated group.
- Ceftiofur sodium showed slightly better results, with 78.6% of the horses recorded as having completely recovered, as compared to 59.3% of the horses treated with Ampicillin sodium.
- Ceftiofur sodium was effective in reducing body temperature to afebrile levels after 2 days of treatment, similar to Ampicillin sodium.
- Supporting variables such as depression, respiration difficulties, and nasal discharge, further validated the effectiveness of both treatments.
- Neither of the antibiotics caused side effects such as pain at the injection site, swelling, or diarrhea.
Conclusion
- The results from this study suggest that Ceftiofur sodium is an effective and safe treatment for respiratory infections in horses, and it performs slightly better than Ampicillin sodium in achieving complete recoveries.
Cite This Article
APA
Dyke TM, Hinchcliff KW.
(1993).
Treatment of respiratory infections in horses with ceftiofur sodium.
Equine Vet J, 25(3), 197-198.
Publication
Researcher Affiliations
MeSH Terms
- Ampicillin / administration & dosage
- Ampicillin / therapeutic use
- Animals
- Cephalosporins / adverse effects
- Cephalosporins / therapeutic use
- Horse Diseases / drug therapy
- Horses
- Respiratory Tract Infections / drug therapy
- Respiratory Tract Infections / veterinary
Citations
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