Use of a 3-Telsa magnet to perform delayed gadolinium-enhanced magnetic resonance imaging of the distal interphalangeal joint of horses with and without naturally occurring osteoarthritis.
Abstract: OBJECTIVE To characterize delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) features of healthy hyaline cartilage of the distal interphalangeal joint (DIPJ) of horses, to determine whether dGEMRIC can be used to differentiate various stages of naturally occurring osteoarthritis of the DIPJ, and to correlate relaxation times determined by dGEMRIC with the glycosaminoglycan concentration, water content, and macroscopic and histologic findings of hyaline cartilage of DIPJs with and without osteoarthritis. SAMPLE 1 cadaveric forelimb DIPJ from each of 12 adult warmblood horses. PROCEDURES T1-weighted cartilage relaxation times were obtained for predetermined sites of the DIPJ before (T1) and after (T1) intra-articular gadolinium administration. Corresponding cartilage sites underwent macroscopic, histologic, and immunohistochemical evaluation, and cartilage glycosaminoglycan concentration and water content were determined. Median T1 and T1 were correlated with macroscopic, histologic, and biochemical data. Mixed generalized linear models were created to evaluate the effects of cartilage site, articular surface, and macroscopic and histologic scores on relaxation times. RESULTS 122 cartilage specimens were analyzed. Median T1 was lower than the median T1 for normal and diseased cartilage. Both T1 and T1 were correlated with macroscopic and histologic scores, whereby T1 increased and T1 decreased as osteoarthritis progressed. There was topographic variation of T1 and T1 within the DIPJ. Cartilage glycosaminoglycan concentration and water content were significantly correlated with T1 and macroscopic and histologic scores but were not correlated with T1. CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that dGEMRIC relaxation times varied for DIPJs with various degrees of osteoarthritis. These findings may help facilitate early detection of osteoarthritis.
Publication Date: 2018-02-22 PubMed ID: 29466042DOI: 10.2460/ajvr.79.3.287Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The study covers the use of delayed gadolinium-enhanced magnetic resonance imaging (dGEMRIC) to determine horses’ osteoarthritis at different stages. It also evaluates correlations between relaxation times achievable via dGEMRIC and the concentration of glycosaminoglycans, water content, and findings from histologic and macroscopic examinations of the hyaline cartilage in the distal interphalangeal joint (DIPJ).
Research Procedure
- The research used one cadaveric forelimb DIPJ from each of the twelve warmblood horses involved.
- Two measurable relaxation times were obtained, identified as T1 and T1, before and after an intra-articular gadolinium administration.
- The corresponding cartilage sites underwent evaluations that were immunohistochemical, macroscopic, and histologic in nature.
- The researchers also determined the concentration of cartilage glycosaminoglycan and water content.
- Both the T1 and T1 relaxation times were cross-compared with histologic, macroscopic, and biochemical data using mixed generalized linear models.
Results
- The study analysed 122 cartilage specimens in total.
- The median T1 was conclusively lower than the T1 median for both normal and diseased cartilage.
- Both the T1 and T1 relaxation times corresponded significantly with histologic and macroscopic scores, marking progressions in osteoarthritis.
- It was found that there were topographic variations of both T1 and T1 within the DIPJ.
- The study found the glycosaminoglycan concentration in the cartilage and water content to be significantly correlated with macroscopic and histologic scores, but not with T1.
Conclusions and Clinical Relevance
- The research concluded that osteoarthritis conditions in DIPJs yielded varying dGEMRIC relaxation times, forming the basis for its potential role in early detection of osteoarthritis in horses.
Cite This Article
APA
Bischofberger AS, Fürst AE, Torgerson PR, Carstens A, Hilbe M, Kircher P.
(2018).
Use of a 3-Telsa magnet to perform delayed gadolinium-enhanced magnetic resonance imaging of the distal interphalangeal joint of horses with and without naturally occurring osteoarthritis.
Am J Vet Res, 79(3), 287-298.
https://doi.org/10.2460/ajvr.79.3.287 Publication
Researcher Affiliations
MeSH Terms
- Animals
- Cartilage, Articular / pathology
- Contrast Media
- Extremities
- Gadolinium
- Glycosaminoglycans
- Horse Diseases / diagnostic imaging
- Horses
- Magnetic Resonance Imaging / instrumentation
- Magnetic Resonance Imaging / methods
- Magnetic Resonance Imaging / veterinary
- Magnets
- Osteoarthritis / diagnostic imaging
- Osteoarthritis / pathology
- Osteoarthritis / veterinary
- Toe Phalanges / diagnostic imaging
Citations
This article has been cited 2 times.- van Zadelhoff C, Schwarz T, Smith S, Engerand A, Taylor S. Identification of Naturally Occurring Cartilage Damage in the Equine Distal Interphalangeal Joint Using Low-Field Magnetic Resonance Imaging and Magnetic Resonance Arthrography.. Front Vet Sci 2019;6:508.
- Evrard L, Audigié F, Bertoni L, Jacquet S, Denoix JM, Busoni V. Low field magnetic resonance imaging of the equine distal interphalangeal joint: Comparison between weight-bearing and non-weight-bearing conditions.. PLoS One 2019;14(1):e0211101.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
