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Home / Equine Research Bank / Can J Vet Res / Use of a novel one-nostril mask-spacer device to evaluate ai...
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire2014; 78(3); 214-220;

Use of a novel one-nostril mask-spacer device to evaluate airway hyperresponsiveness (AHR) in horses after chronic administration of albuterol.

Abstract: Inflammatory airway disease (IAD) is very common in stabled horses. Short-acting beta agonist (SABA) drugs are often used to relieve clinical signs, although long-term exposure to these drugs may result in rebound bronchoconstriction. The purpose of this study was twofold: i) to describe the deposition of radiolabeled drugs using a novel one-nostril design mask-spacer combination with a breath-activated inhaler (BAI), and ii) to determine whether treatment for 10 d with inhaled albuterol using this device would impair the ability of albuterol to prevent bronchospasm during a histamine challenge test. The percentage of radio-aerosol deposited in the total lung was 12.39% ± 5.05%. All study horses demonstrated airway hyperresponsiveness (AHR) before enrollment in the study [mean provocative concentration eliciting 35% increase in delta flow (PC35) < 6 mg/mL histamine]. There was no significant difference in airway hyperresponsiveness to post-albuterol histamine challenge before or after treatment with albuterol. A 10-d treatment with placebo, however, caused a significant increase in airway hyperresponsiveness in all horses (P < 0.001). The results of this study show that the novel mask-spacer device was effective in delivering radiolabeled aerosolized drug to the lung and that delivery of a SABA for 10 d using this device did not result in increased airway hyperresponsiveness. La maladie inflammatoire des voies respiratoires (IAD) est très courante chez les chevaux gardés en écurie. Les médicaments agonistes bêta à courte action (SABA) sont souvent utilisés pour soulager les signes cliniques, bien qu’une exposition prolongée à ces médicaments puisse résulter en une bronchoconstriction rebond. Le but de la présente étude était double : i) décrire le dépôt de médicaments radio-marqués en utilisant un nouveau design de chambre d’inhalation pour une seule narine avec un inhalateur activé par l’haleine (BAI), et ii) déterminer si un traitement pendant 10 j avec de l’albuterol inhalé avec cet appareil compromettrait la capacité de l’albuterol à prévenir un bronchospasme durant un test défi à l’histamine. Le pourcentage d’aérosol radio-marqué déposé dans le poumon total était de 12,39 % ± 5,05 %. Tous les chevaux dans l’étude ont montré une hyperréactivité des voies respiratoires (AHR) avant l’incorporation dans l’étude [concentration moyenne induisant une augmentation de 35 % du delta flot (PC35) < 6 mg/mL d’histamine]. Il n’y avait pas de différence significative d’hyperréactivité des voies respiratoires au challenge à l’histamine post-albuterol avant ou après traitement avec de l’albuterol. Toutefois, un traitement pendant 10 j avec un placebo a causé une augmentation significative d’hyperréactivité des voies respiratoires chez tous les chevaux ( < 0,001). Les résultats de la présente étude ont montré que le nouveau design d’inhalateur était efficace pour la distribution par aérosol de médicament radio-marqué dans les poumons et que l’administration de SABA pendant 10 j à l’aide de cet appareil n’a pas causé d’augmentation de l’hyperréactivité des voies respiratoires.(Traduit par Docteur Serge Messier).
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Publication Date: 2014-07-02 PubMed ID: 24982553PubMed Central: PMC4068413
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  • Journal Article
  • Randomized Controlled Trial
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research paper presents a study of a novel one-nostril mask-spacer device employed to evaluate airway hyperresponsiveness in horses after chronic administration of the drug, albuterol. The study showed that the new mask-spacer device was effective for delivering aerosolized drug to the lungs, and 10-day usage did not cause increased airway hyperresponsiveness.

Objective of the Study

  • The study was conducted with two major goals: Firstly, to describe the deposition of radiolabeled drugs using a new one-nostril design mask-spacer combination with a breath-activated inhaler (BAI). It aimed to assess how effectively the device can deliver the medication directly to the lungs. Secondly, to investigate if a 10-day treatment using inhaled albuterol with this device would affect albuterol’s ability to prevent bronchospasm during a histamine challenge test.

Methods Used

  • The research team used radiolabeled aerosolized drugs to precisely detail their deposition in the respiratory system when applied via the one-nostril mask-spacer device. This methodology helped them quantify the level of drug delivered to the lungs.
  • They ran a histamine challenge test before and after the treatment with albuterol to probe if there is any change in airway hyperresponsiveness. This test helped to determine whether the bronchial tubes of the horses would respond differently to histamine – a neurotransmitter that can cause narrowing of the airways – after the medication was administered.

Results of the Study

  • The study found that the one-nostril mask-spacer device successfully delivered 12.39% ± 5.05% of the radiolabeled aerosol to the lungs. This indicated a reasonably effective delivery of the medication directly into the lungs.
  • All the horses included in the study exhibited airway hyperresponsiveness before the start of the treatment. However, there was no significant increase in airway hyperresponsiveness to post-albuterol histamine challenge before or after the treatment with albuterol. This implies that chronic administration of the drug didn’t alter the airway reaction to histamine.
  • A notable outcome was that a 10-day placebo treatment resulted in a significant increase in airway hyperresponsiveness across all horses. This suggests implicitly that horses could be prone to increased airway reaction in absence of the drug.

Conclusion of the Study

  • The findings led to the conclusion that the novel mask-spacer device is effective in delivering aerosolized drugs to the lungs of horses. Moreover, a 10-day administration of a short-acting beta agonist drug like albuterol, utilizing this device, didn’t lead to increased airway hyperresponsiveness.
  • The results reinforce the need for well-designed inhalation devices for horses, specifically those suffering from inflammatory airway disease, to facilitate better aerosol drug delivery and potentially improve treatment outcomes.

Cite This Article

APA
Mazan MR, Lascola K, Bruns SJ, Hoffman AM. (2014). Use of a novel one-nostril mask-spacer device to evaluate airway hyperresponsiveness (AHR) in horses after chronic administration of albuterol. Can J Vet Res, 78(3), 214-220.

Publication

Canadian journal of veterinary research = Revue canadienne de recherche veterinaire
ISSN: 1928-9022
NlmUniqueID: 8607793
Country: Canada
Language: English
Volume: 78
Issue: 3
Pages: 214-220

Researcher Affiliations

Mazan, Melissa R
  • Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts 01536, USA (Mazan, Hoffman); Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61801, USA (Lascola); Equine Health Studies Program, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana 70803, USA (Bruns).
Lascola, Kara
  • Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts 01536, USA (Mazan, Hoffman); Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61801, USA (Lascola); Equine Health Studies Program, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana 70803, USA (Bruns).
Bruns, Susan J
  • Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts 01536, USA (Mazan, Hoffman); Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61801, USA (Lascola); Equine Health Studies Program, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana 70803, USA (Bruns).
Hoffman, Andrew M
  • Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts 01536, USA (Mazan, Hoffman); Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61801, USA (Lascola); Equine Health Studies Program, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana 70803, USA (Bruns).

MeSH Terms

  • Administration, Inhalation
  • Adrenergic beta-2 Receptor Agonists / administration & dosage
  • Adrenergic beta-2 Receptor Agonists / pharmacology
  • Aerosols
  • Albuterol / administration & dosage
  • Albuterol / pharmacology
  • Animals
  • Bronchial Provocation Tests
  • Drug Administration Schedule
  • Female
  • Histamine / administration & dosage
  • Histamine / pharmacology
  • Histamine Agonists / administration & dosage
  • Histamine Agonists / pharmacology
  • Horses / physiology
  • Nebulizers and Vaporizers

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Citations

This article has been cited 6 times.
  1. Minuto J, Bedenice D, Ceresia M, Zaghloul I, Böhlke M, Mazan MR. Clinical effects and pharmacokinetics of nebulized lidocaine in healthy horses.. Front Vet Sci 2022;9:984108.
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  2. Klier J, Fuchs S, Winter G, Gehlen H. Inhalative Nanoparticulate CpG Immunotherapy in Severe Equine Asthma: An Innovative Therapeutic Concept and Potential Animal Model for Human Asthma Treatment.. Animals (Basel) 2022 Aug 16;12(16).
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  3. Mahalingam-Dhingra A, Mazan MR, Bedenice D, Ceresia M, Minuto J, Deveney EF. A CONSORT-guided, randomized, double-blind, controlled pilot clinical trial of inhaled lidocaine for the treatment of equine asthma.. Can J Vet Res 2022 Apr;86(2):116-124.
    pubmed: 35388235
  4. Lavoie JP, Leclere M, Rodrigues N, Lemos KR, Bourzac C, Lefebvre-Lavoie J, Beauchamp G, Albrecht B. Efficacy of inhaled budesonide for the treatment of severe equine asthma.. Equine Vet J 2019 May;51(3):401-407.
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