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Use of immunohistochemical staining and electron microscopy to aid in diagnosis of soft tissue sarcomas associated with the fetlock joint in two horses.
Abstract: Soft tissue sarcomas of the equine distal limb associated with joints, sheaths, or bursae have rarely been reported. Accurate diagnosis of these tumors is challenging in both human beings and veterinary species. Immunohistochemical staining and transmission electron microscopy have been used in human beings to reduce misdiagnosis. The current report describes 2 mature horses presenting with lameness and swelling associated with the dorsal aspect of the metacarpo(tarso)phalangeal joint. In both cases, surgical excision was performed with subsequent histological analysis of the masses to determine the tissue of origin. In both cases, immunohistochemical staining and transmission electron microscopy aided the definitive diagnosis of fibrosarcoma associated with the fetlock joints of 2 horses.
© 2014 The Author(s).
Publication Date: 2014-04-16 PubMed ID: 24741022DOI: 10.1177/1040638714529951Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
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The research explores the use of immunohistochemical staining and electron microscopy to diagnose soft tissue sarcomas in the fetlock joints of two horses.
Introduction
In this study, the researchers delve into soft tissue sarcomas (a type of cancer) found in the distal limb of horses. These tumors are rarely reported and their accurate diagnosis is difficult in both human beings and veterinary species. To reduce the instances of misdiagnosis, human beings have employed techniques like immunohistochemical staining and transmission electron microscopy.
Methodology
- The researchers focused on two horses that showed signs of lameness and swelling linked with the dorsal aspect of their metacarpo(tarso)phalangeal joint – a joint found in the fetlock region of a horse’s limb.
- Surgical excision was performed on both horses and the removed masses were then subjected to histological analysis to pinpoint the tissue of origin.
Results
- The histological analysis provided valuable insight but it was the techniques of immunohistochemical staining and transmission electron microscopy that gave a definitive diagnosis.
- The two methods were successful in diagnosing fibrosarcoma (a specific type of soft tissue sarcoma) associated with the fetlock joints in both horses.
Conclusion
The research concluded that methods such as immunohistochemical staining and transmission electron microscopy, which are used in human medicine, can be very effective in diagnosing soft tissue sarcomas in horses. This paves the way for more reliable diagnosis of tumors in veterinary species, leading to better treatment plans and outcomes. It also presents the possibility of being used in diagnosing other types of tumors found in different species.
Cite This Article
APA
Findley JA, Singer ER, Milner PI, Leeming GH.
(2014).
Use of immunohistochemical staining and electron microscopy to aid in diagnosis of soft tissue sarcomas associated with the fetlock joint in two horses.
J Vet Diagn Invest, 26(3), 465-469.
https://doi.org/10.1177/1040638714529951 Publication
Researcher Affiliations
- Clinical Sciences (Findley), School of Veterinary Science, University of Liverpool, Leahurst, Neston, Cheshire, United KingdomInstitute for Aging and Chronic Disease (Singer, Milner), School of Veterinary Science, University of Liverpool, Leahurst, Neston, Cheshire, United KingdomVeterinary Pathology (Leeming), School of Veterinary Science, University of Liverpool, Leahurst, Neston, Cheshire, United Kingdom.
- Clinical Sciences (Findley), School of Veterinary Science, University of Liverpool, Leahurst, Neston, Cheshire, United KingdomInstitute for Aging and Chronic Disease (Singer, Milner), School of Veterinary Science, University of Liverpool, Leahurst, Neston, Cheshire, United KingdomVeterinary Pathology (Leeming), School of Veterinary Science, University of Liverpool, Leahurst, Neston, Cheshire, United Kingdom.
- Clinical Sciences (Findley), School of Veterinary Science, University of Liverpool, Leahurst, Neston, Cheshire, United KingdomInstitute for Aging and Chronic Disease (Singer, Milner), School of Veterinary Science, University of Liverpool, Leahurst, Neston, Cheshire, United KingdomVeterinary Pathology (Leeming), School of Veterinary Science, University of Liverpool, Leahurst, Neston, Cheshire, United Kingdom.
- Clinical Sciences (Findley), School of Veterinary Science, University of Liverpool, Leahurst, Neston, Cheshire, United KingdomInstitute for Aging and Chronic Disease (Singer, Milner), School of Veterinary Science, University of Liverpool, Leahurst, Neston, Cheshire, United KingdomVeterinary Pathology (Leeming), School of Veterinary Science, University of Liverpool, Leahurst, Neston, Cheshire, United Kingdom gail.leeming@liverpool.ac.uk.
Citations
This article has been cited 1 times.- Namjou A, Kheyrandish R, GholamZadeh A, Kiani FZ, Shirian S. Histological and Immunohistochemical Findings of an Extremely Rare Multi-Organ Metastasis of Fibrosarcoma in a Holstein Cow. Vet Med Sci 2025 Sep;11(5):e70567.
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