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The Veterinary record1999; 144(10); 259-261; doi: 10.1136/vr.144.10.259

Use of phenytoin to treat digitalis-induced cardiac arrhythmias in a miniature Shetland pony.

Abstract: Two miniature Shetland ponies showing clinical signs of Digitalis purpurea (foxglove) poisoning were examined. One animal died shortly afterwards, but the second was treated successfully with the anti-arrhythmic agent, phenytoin, and was discharged after 16 days.
Publication Date: 1999-04-21 PubMed ID: 10209818DOI: 10.1136/vr.144.10.259Google Scholar: Lookup
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Summary

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The article discusses a case where two miniature Shetland ponies were exposed to Digitalis purpurea (foxglove) poisoning and displayed heart irregularities. While one pony passed away, the other was successfully treated with an anti-arrhythmia drug, phenytoin, and improved after 16 days.

Introduction

  • The article is centred around two miniature Shetland ponies that showed symptoms of poisoning from Digitalis purpurea, commonly known as foxglove.
  • Foxglove poisoning is known to cause cardiac arrhythmias – a condition where the heart beats at an irregular speed, often too fast or too slow.

Cases

  • One of the Shetland ponies died shortly after displaying symptoms of the poisoning.
  • The other pony was treated with phenytoin, a medication commonly used to treat cardiac arrhythmias.]
  • This pony responded positively to the treatment and was discharged after 16 days.

Treatment Method

  • The research article focuses specifically on the application of the drug phenytoin to treat cardiac arrhythmias, a result of Digitalis purpurea poisoning in this case.
  • Phenytoin is generally used to control seizures, but it also has anti-arrhythmic properties. It is one of the few drugs that can be used to control heart rate without lowering the blood pressure.

Conclusion

  • This study points out that the use of phenytoin can be successful in treating Digitalis purpurea-induced cardiac arrhythmias in equines, as demonstrated with the miniature Shetland pony.
  • The positive outcome underlines the potential of phenytoin as an effective treatment option in similar cases, offering a lifeline for animals that have been poisoned by foxglove.

Cite This Article

APA
Wijnberg ID, van der Kolk JH, Hiddink EG. (1999). Use of phenytoin to treat digitalis-induced cardiac arrhythmias in a miniature Shetland pony. Vet Rec, 144(10), 259-261. https://doi.org/10.1136/vr.144.10.259

Publication

ISSN: 0042-4900
NlmUniqueID: 0031164
Country: England
Language: English
Volume: 144
Issue: 10
Pages: 259-261

Researcher Affiliations

Wijnberg, I D
  • Department of Large Animal Medicine and Nutrition, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
van der Kolk, J H
    Hiddink, E G

      MeSH Terms

      • Animals
      • Anti-Arrhythmia Agents / pharmacology
      • Anti-Arrhythmia Agents / therapeutic use
      • Arrhythmias, Cardiac / drug therapy
      • Arrhythmias, Cardiac / veterinary
      • Digitalis / poisoning
      • Female
      • Horse Diseases / drug therapy
      • Horse Diseases / etiology
      • Horses
      • Phenytoin / pharmacology
      • Phenytoin / therapeutic use
      • Plant Poisoning / drug therapy
      • Plant Poisoning / veterinary
      • Plants, Medicinal
      • Plants, Toxic

      Citations

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