Use of phenytoin to treat digitalis-induced cardiac arrhythmias in a miniature Shetland pony.
Abstract: Two miniature Shetland ponies showing clinical signs of Digitalis purpurea (foxglove) poisoning were examined. One animal died shortly afterwards, but the second was treated successfully with the anti-arrhythmic agent, phenytoin, and was discharged after 16 days.
Publication Date: 1999-04-21 PubMed ID: 10209818DOI: 10.1136/vr.144.10.259Google Scholar: Lookup
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- Case Reports
- Journal Article
- Cardiac Arrhythmias
- Case Reports
- Clinical Pathology
- Clinical Signs
- Diagnosis
- Disease Diagnosis
- Disease Management
- Disease Treatment
- Equine Diseases
- Equine Health
- Horses
- Miniature Horses
- Pharmaceuticals
- Pharmacology
- Poisoning
- Shetland Ponies
- Toxic plants
- Veterinary Care
- Veterinary Medicine
- Veterinary Practice
- Veterinary Research
Summary
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The article discusses a case where two miniature Shetland ponies were exposed to Digitalis purpurea (foxglove) poisoning and displayed heart irregularities. While one pony passed away, the other was successfully treated with an anti-arrhythmia drug, phenytoin, and improved after 16 days.
Introduction
- The article is centred around two miniature Shetland ponies that showed symptoms of poisoning from Digitalis purpurea, commonly known as foxglove.
- Foxglove poisoning is known to cause cardiac arrhythmias – a condition where the heart beats at an irregular speed, often too fast or too slow.
Cases
- One of the Shetland ponies died shortly after displaying symptoms of the poisoning.
- The other pony was treated with phenytoin, a medication commonly used to treat cardiac arrhythmias.]
- This pony responded positively to the treatment and was discharged after 16 days.
Treatment Method
- The research article focuses specifically on the application of the drug phenytoin to treat cardiac arrhythmias, a result of Digitalis purpurea poisoning in this case.
- Phenytoin is generally used to control seizures, but it also has anti-arrhythmic properties. It is one of the few drugs that can be used to control heart rate without lowering the blood pressure.
Conclusion
- This study points out that the use of phenytoin can be successful in treating Digitalis purpurea-induced cardiac arrhythmias in equines, as demonstrated with the miniature Shetland pony.
- The positive outcome underlines the potential of phenytoin as an effective treatment option in similar cases, offering a lifeline for animals that have been poisoned by foxglove.
Cite This Article
APA
Wijnberg ID, van der Kolk JH, Hiddink EG.
(1999).
Use of phenytoin to treat digitalis-induced cardiac arrhythmias in a miniature Shetland pony.
Vet Rec, 144(10), 259-261.
https://doi.org/10.1136/vr.144.10.259 Publication
Researcher Affiliations
- Department of Large Animal Medicine and Nutrition, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
MeSH Terms
- Animals
- Anti-Arrhythmia Agents / pharmacology
- Anti-Arrhythmia Agents / therapeutic use
- Arrhythmias, Cardiac / drug therapy
- Arrhythmias, Cardiac / veterinary
- Digitalis / poisoning
- Female
- Horse Diseases / drug therapy
- Horse Diseases / etiology
- Horses
- Phenytoin / pharmacology
- Phenytoin / therapeutic use
- Plant Poisoning / drug therapy
- Plant Poisoning / veterinary
- Plants, Medicinal
- Plants, Toxic
Citations
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