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Uterine artery blood flow remains unchanged in pregnant mares in response to short-term administration of pentoxifylline.
Abstract: The objective of this study was to use Doppler ultrasound technology to determine whether pentoxifylline administration increased uterine blood flow in normal pregnant pony mares. Thirteen pregnant pony mares between 18 and 190 d of gestation (mean ± SEM, 101 ± 55) were utilized for the study during two trial periods. In each trial, pentoxifylline (17 mg/kg by mouth every 12h, diluted in syrup) was administered to half of the mares for 3 d, while the other mares were treated with syrup only. Doppler measurements were obtained from the right and left uterine arteries from each mare for 2 d prior to treatment and throughout the treatment period. The mean Resistivity Index (RI), Pulsatility Index (PI), Uterine Artery Diameter (D), and Total Arterial Blood Flow (TABF) from each day were compared over time and between groups. Administration of pentoxifylline did not alter uterine blood flow parameters compared with controls (values for all treatment days combined were RI: 0.517 ± 0.014 vs 0.543 ± 0.016; PI: 0.876 ± 0.048 vs 0.927 ± 0.057; D: 0.388 ± 0.018 vs 0.379 ± 0.023 cm; and TABF: 35.26 ± 7.38 vs 30.73 ± 5.29 mL/min). Uterine blood flow increased over the course of the 5 d study, irrespective of treatment, and was higher in mares of greater gestational age than in early gestational mares (RI: r(2) = 0.35; PI: r(2) = 0.37; D: r(2) = 0.66; and TABF: r(2) = 0.67 - P < 0.00001). We concluded that any immediate benefits of pentoxifylline administration in the pregnant mare were not mediated through enhanced uterine artery blood flow.
Copyright © 2012 Elsevier Inc. All rights reserved.
Publication Date: 2011-09-29 PubMed ID: 21958635DOI: 10.1016/j.theriogenology.2011.08.018Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
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The research article investigates the effect of short-term administration of pentoxifylline on uterine artery blood flow in pregnant ponies. The study finds that pentoxifylline does not change uterine blood flow compared to controls, concluding that any immediate benefits of the medication in pregnant mares are not due to increased uterine artery blood flow.
Study Design
- The study was premised on determining if the administration of pentoxifylline enhances uterine blood flow in pregnant pony mares.
- The researchers employed Doppler ultrasound technology in their investigation.
- The sample for the study included thirteen pregnant pony mares that were between 18 and 190 days of gestation.
- The study was conducted during two trial periods during which the mares were either administered pentoxifylline or a syrup-only treatment as the control.
Methodology
- Pentoxifylline was administered orally at a dosage of 17 mg/kg every 12 hours for three days, diluted in syrup.
- Doppler readings were obtained from the right and left uterine arteries from each mare for two days prior to the treatment and during the treatment period.
- The researchers analyzed several parameters, including Resistivity Index (RI), Pulsatility Index (PI), Uterine Artery Diameter (D), and Total Arterial Blood Flow (TABF).
- The values obtained each day were compared over time and between the two groups — the group of mares that received pentoxifylline and the control group.
Findings
- The administration of pentoxifylline did not alter uterine blood flow parameters compared to the control group.
- The study also found that uterine blood flow generally increased over time, irrespective of treatment, and that it was greater in mares of advanced gestational age than in those in early gestation.
Conclusion
- The researchers concluded that the immediate benefits of pentoxifylline administration in pregnant mares were not due to enhanced uterine artery blood flow.
Cite This Article
APA
Bailey CS, Sper RB, Schewmaker JL, Buchanan CN, Beachler TM, Pozor MA, Whitacre MD.
(2011).
Uterine artery blood flow remains unchanged in pregnant mares in response to short-term administration of pentoxifylline.
Theriogenology, 77(2), 430-436.
https://doi.org/10.1016/j.theriogenology.2011.08.018 Publication
Researcher Affiliations
- College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA. scott_bailey@ncsu.edu
MeSH Terms
- Animals
- Female
- Gestational Age
- Horses / physiology
- Pentoxifylline / administration & dosage
- Pregnancy
- Pulsatile Flow / drug effects
- Regional Blood Flow / drug effects
- Ultrasonography, Doppler, Color / veterinary
- Uterine Artery / diagnostic imaging
- Uterine Artery / drug effects
- Uterine Artery / physiology
- Vascular Resistance / drug effects
- Vasodilator Agents / administration & dosage
Citations
This article has been cited 3 times.- Abdelnaby EA, Emam IA, El-Sherbiny HR, Fadl AM. The effects of aging and gestational month on uteroplacental vascular perfusion, and umbilical artery hemodynamics in pregnant jennies. BMC Vet Res 2022 Nov 15;18(1):404.
- Ortega-Ferrusola C, Gómez-Arrones V, Martín-Cano FE, Gil MC, Peña FJ, Gaitskell-Phillips G, Da Silva-Álvarez E. Advances in the ultrasound diagnosis in equine reproductive medicine: New approaches. Reprod Domest Anim 2022 Oct;57 Suppl 5(Suppl 5):34-44.
- Hardefeldt L, Thomas K, Page S, Norris J, Browning G, El Hage C, Stewart A, Gilkerson J, Muscatello G, Verwilghen D, van Galen G, Bauquier J, Cuming R, Reynolds B, Whittaker C, Wilkes E, Clulow J, Burden C, Begg L. Antimicrobial prescribing guidelines for horses in Australia. Aust Vet J 2025 Dec;103(12):781-889.
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